Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephen Tomusange"'
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Autor:
Guinevere Q. Lee, Pragya Khadka, Sarah N. Gowanlock, Dennis C. Copertino, Maggie C. Duncan, F. Harrison Omondi, Natalie N. Kinloch, Jingo Kasule, Taddeo Kityamuweesi, Paul Buule, Samiri Jamiru, Stephen Tomusange, Aggrey Anok, Zhengming Chen, R. Brad Jones, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Zabrina L. Brumme, Andrew D. Redd, Jessica L. Prodger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males in the United States and Euro
Externí odkaz:
https://doaj.org/article/8753461e8307400b835f50ad980f61a1
Autor:
Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S. Mann, Eric J. Arts
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 lat
Externí odkaz:
https://doaj.org/article/c4e48e2d64a24cd4aecbe0e0f13130b6
Autor:
Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen R. Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F.Y. Poon, Thomas C. Quinn, Jessica L. Prodger, Andrew D. Redd
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105040- (2024)
Summary: Background: The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegr
Externí odkaz:
https://doaj.org/article/7fa7f6eb718b411a877cdd47fd239934
Autor:
M Kate Grabowski, Josephine Mpagazi, Stephen Kiboneka, Robert Ssekubugu, John Baptiste Kereba, Annet Nakayijja, Julius Tukundane, Jade C Jackson, Austin D Peer, Caitlin Kennedy, Godfrey Kigozi, Ronald M Galiwango, Yukari C Manabe, Larry W Chang, Sarah Kalibala, Ronald H Gray, Maria J Wawer, Steven J Reynolds, Aaron A R Tobian, David Serwadda, Charlotte A Gaydos, Joseph Kagaayi, Thomas C Quinn, Dorean Nabukalu, Anthony Ndyanabo, Joseph Ssekasanvu, Hadijja Nakawooya, Jessica Nakukumba, Grace N. Kigozi, Betty S. Nantume, Nampijja Resty, Jedidah Kambasu, Margaret Nalugemwa, Regina Nakabuye, Lawrence Ssebanobe, Justine Nankinga, Adrian Kayiira, Gorreth Nanfuka, Ruth Ahimbisibwe, Stephen Tomusange, Ronald M. Galiwango, Margaret Nakalanzi, Aisha Nalukwago, Joseph Ouma Otobi, Denis Ankunda, Joseph Lister Ssembatya, John Baptist Ssemanda, Robert Kairania, Emmanuel Kato, Alice Kisakye, James Batte, James Ludigo, Abisagi Nampijja, Steven Watya, Kighoma Nehemia, Sr Margaret Anyokot, Joshua Mwinike, George Kibumba, Paschal Ssebowa, George Mondo, Francis Wasswa, Agnes Nantongo, Rebecca Kakembo, Josephine Galiwango, Geoffrey Ssemango, Andrew D. Redd, John Santelli, Oliver Laeyendecker, Jennifer Wagman, Rey Fernandez, Nelson Sewankambo, Yasmin Ogale
Publikováno v:
The Lancet Global Health. 10:e1825-e1834
Combination HIV prevention and treatment interventions (CHIs) have led to substantial declines in HIV incidence in sub-Saharan Africa; however, population-level data on non-HIV sexually transmitted infections (STIs) in the context of CHIs are rare. W
Autor:
Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F. Y. Poon, Thomas C. Quinn, Jessica L. Prodger, Andrew D. Redd
Publikováno v:
medRxiv
The principal barrier to an HIV cure is the presence of a latent viral reservoir (LVR) made up primarily of latently infected resting CD4+ (rCD4) T-cells. Studies in the United States have shown that the LVR decays slowly (half-life=3.8 years), but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90224c973a1651f36a6602a6f26f36e
https://europepmc.org/articles/PMC10246077/
https://europepmc.org/articles/PMC10246077/
Autor:
Jennifer A. Wagman, Joshua Mwinike, Thomas C. Quinn, Stella Alamo, Nampijja Resty, Lisa J. Nelson, Justine Nankinga, Maria J. Wawer, George Mondo, Denis Ankunda, Abisagi Nampijja, Anthony Ndyanabo, Steven Watya, Steven J. Reynolds, Agnes Nantongo, Paschal Ssebowa, Ronald H. Gray, John Baptist Ssemanda, Caitlin E. Kennedy, Joseph Kagaayi, Joseph Ssekasanvu, Gorreth Nanfuka, David Serwadda, Geoffrey Ssemango, Stephen Tomusange, Godfrey Kigozi, Gideon Loevinsohn, Oliver Laeyendecker, Hadijja Nakawooya, Betty Nantume, Regina Nakabuye, Geoffrey Kabuye, Joseph Lister Ssembatya, Jessica Nakukumba, Josephine Galiwango, M. Kathryn Grabowski, Adrian Kayiira, Lisa A. Mills, Andrew D. Redd, Robert Kairania, Emmanuel Kato, Ronald M. Galiwango, Jedidah Kambasu, Tom Lutalo, Gertrude Nakigozi, Larry W. Chang, Grace Kigozi, Margaret Nalugemwa, John S. Santelli, Joseph Ouma Otobi, Ruth Ahimbisibwe, James Batte, Fred Makumbi, Rebecca Kakembo, Sr. Margaret Anyokot, Fred Nalugoda, Lawrence Ssebanobe, James Ludigo, Robert Ssekubugu, Sarah Kalibbali, Aaron A.R. Tobian, Francis Wasswa, Alice Kisakye, Nelson K. Sewankambo, George Kibumba, Kighoma Nehemia, Margaret Nakalanzi, Dorean Nabukalu
Publikováno v:
Clin Infect Dis
Background The efficacy of voluntary male medical circumcision (VMMC) for human immunodeficiency virus (HIV) prevention in men was demonstrated in 3 randomized trials. This led to the adoption of VMMC as an integral component of the United States Pre
Autor:
Abisagi Nampijja, Regina Nakabuye, Ronald H. Gray, Justine Nankinga, Myron S. Cohen, Vladimir Novitsky, James Batte, Joseph Lister Ssembatya, Joshua Mwinike, Sarah Kalibbala, Adrian Kayiira, Fred Makumbi, Steven J. Reynolds, Nampijja Resty, George Kibumba, David Bonsall, Robert Kairania, Agnes Nantongo, Dan Frampton, Francis Wasswa, Jennifer A. Wagman, Astrid Gall, Oliver Ratmann, Grace Kigozi, Larry W. Chang, Steven Watya, Jeremiah Bazaale, Frank Tanser, Helen Ayles, Sr. Margaret Anyokot, George Mondo, Lawrence Ssebanobe, Denis Ankunda, Janet Seeley, Matthew Hall, Anthony Ndyanabo, Joseph Ouma Otobi, Thomas C. Quinn, Aaron A.R. Tobian, Paschal Ssebowa, James Ludigo, Tanya Golubchick, Nelson K. Sewankambo, Ronald Galiwango, Dorean Nabukalu, Maria J. Wawer, Caitlin E. Kennedy, Josephine Galiwango, Jedidah Kambasu, Godfrey Kigozi, Emmanuel Kato, Tulio de Oliveira, Margaret Nalugemwa, John Baptist Ssemanda, Tom Lutalo, Anne Hoppe, Cissy Kityo, Rory Bowden, Gertrude Nakigozi, Max Essex, Joseph Kagaayi, Rebecca Kakembo, Joseph Ssekasanvu, Ronald M. Galiwango, Anne Dennis, David Serwadda, Geoffrey Ssemango, Stephen Tomusange, Hadijja Nakawooya, Betty Nantume, Jessica Nakukumba, Andrew Rambaut, Andrew D. Redd, Lucie Abeler-Dörner, Deogratius Ssemwanga, Nicholas I. Paton, Josh Herbeck, M. Kate Grabowski, Simon E. F. Spencer, Justin Lessler, John S. Santelli, Ruth Ahimbisibwe, Richard J. Hayes, Fred Nalugoda, Xiaoyue Xi, Alice Kisakye, Robert Ssekubugu, Gorreth Nanfuka, Christophe Fraser, Chris Wymant, Kighoma Nehemia, Sarah Fidler, Margaret Nakalanzi, Jairam R. Lingappa, Oliver Laeyendecker, Pontiano Kaleebu, Vincent Calvez, Deenan Pillay, Paul Kellam
Publikováno v:
The Lancet. HIV
Lancet HIV, 7(3), e173-e183. Elsevier Limited
e183
e173
The Lancet HIV
The Lancet HIV, 2020, 7 (3), pp.e173-e183. ⟨10.1016/S2352-3018(19)30378-9⟩
Lancet HIV, 7(3), e173-e183. Elsevier Limited
e183
e173
The Lancet HIV
The Lancet HIV, 2020, 7 (3), pp.e173-e183. ⟨10.1016/S2352-3018(19)30378-9⟩
International audience; Background: International and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits of geo-targeted control, we assessed the extent to