Výsledky vyhledávání - "Stephen T. Reeders"

Distribution and developmentally regulated expression of murine polycystin

Autor: C. Löhning, Jing Zhou, Anna Pavlova, Stephen T. Reeders, A.-M. Frischauf, Lin Geng, Weining Lu, Yoav Segal, Sanjay K. Nigam, Elvino J. G. Barros

Publikováno v: American Journal of Physiology-Renal Physiology. 272:F451-F459

PKD1, the gene that is mutated in approximately 85% of autosomal dominant polycystic kidney disease (ADPKD) cases in humans, has recently been identified (Eur. PKD Consortium. Cell 77: 881-894, 1994; also, erratum in Cell 78: 1994). The longest open-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7fdabf067ac375007bab4f846ac3e5
https://doi.org/10.1152/ajprenal.1997.272.4.f451

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Identification and localization of polycystin, the PKD1 gene product

Autor: Michael C. Schneider, Alexandra M. Glücksmann-Kuis, Frank A. Carone, Bernard Peissel, Jing Zhou, Nanhua Deng, York Pei, Helmut G. Rennke, Stephen T. Reeders, Yoav Segal, Lin Geng, Maria Ericsson

Publikováno v: Scopus-Elsevier

Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene (PKD1) is the cardinal member of a novel class of proteins. As a first step towards elucidating the function of polycystin and the pathogenesis of ADPKD, three typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d0d845e68ade3fb9e0116b498e5332
https://doi.org/10.1172/jci119090

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Sera from patients with anti-GBM nephritis including Goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen chains

Autor: M. Weber, Karl Tryggvason, X. Zhang, Jean-Michel Foidart, Stephen T. Reeders, Pierre Dehan

Publikováno v: Nephrology Dialysis Transplantation. 11:2215-2222

Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies directed against type IV collagen, which is a major structural c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6ae1e59a03ee3b5b509a6826798c37
https://doi.org/10.1093/oxfordjournals.ndt.a027139

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Autor: Hideki Nomura, Stephen T. Reeders, Anna M. Rodriguez, Cynthia C. Morton, Michael C. Schneider, Jing Zhou, Stanislawa Weremowicz

Publikováno v: Genomics. 38:1-4

We report a partial cDNA sequence that encodes a protein, dubbed “polycystwin,” with 21% identity and 46% similarity to amino acids 3688–4109 of the carboxyl terminus of polycystin, the gene product of the autosomal dominant polycystic kidney d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3a0c580d8c8fe61ec638127432710d
https://doi.org/10.1006/geno.1996.0584

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Structure of the Human Type IV CollagenCOL4A6Gene, Which Is Mutated in Alport Syndrome-Associated Leiomyomatosis

Autor: Jing Zhou, Stephen T. Reeders, Karl Tryggvason, Xu Zhang

Publikováno v: Genomics. 33:473-479

Basement membrane (type IV) collagen, a subfamily of the collagen protein family, is encoded by six distinct genes in mammals. Three of those, COL4A3, COL4A4, and COL4A5, are linked with Alport syndrome (hereditary nephritis). Patients with leimoyoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d91acd91f99748638fd71ce083de89
https://doi.org/10.1006/geno.1996.0222

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No linkage to the COL4A3 gene locus in Japanese thin basement membrane disease families

Autor: Yuichiro Maruyama, Yoichi Nakagawa, Shinichi Nishi, Toshio Mochizuki, Shiro Maruyama, Stephen T. Reeders, Hajime Yamazaki, Masaaki Arakawa, Tetsuro Takeda, Shiminoru Sakatsume, Sojiro Ogino, Akihiko Saito

Publikováno v: Nephrology. 1:315-321

Summary: Patients with thin basement membrane disease (TBMD) exhibit persistent haematuria with a diffuse thinning of the glomerular basement membrane (GBM), especially of the lamina densa. It appears to be an autosomal dominant trait. It has been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4083fafecc37d6230208cd6c38715eb0
https://doi.org/10.1111/j.1440-1797.1995.tb00046.x

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Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains

Autor: Stephen T. Reeders, K Tryggvason, Mariko Mariyama, A Leinonen, T Mochizuki

Publikováno v: Journal of Biological Chemistry. 269:26172-26177

The entire sequence of the human alpha 4(IV) collagen chain was determined from cDNA clones and polymerase chain reaction-amplified DNAs. The complete translation product has 1,690 amino acid residues and the processed alpha 4(IV) chain proper 1,652

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f6e1daf73ec82bb3d6d0a7846e7c3bc
https://doi.org/10.1016/s0021-9258(18)47174-8

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Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains

Autor: Stephen T. Reeders, Ming Ding, Zhihui Zhao, Jing Zhou

Publikováno v: Journal of Biological Chemistry. 269:13193-13199

Basement membranes were previously believed to contain five distinct type IV collagen subunits. We have recently isolated part of the cDNA for a novel type IV collagen, alpha 6(IV), and shown that COL4A6, the gene encoding this new chain, is deleted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72c3842ae6170956453cb8aa716f859
https://doi.org/10.1016/s0021-9258(17)36818-7

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