Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephen T. Kajdasz"'
Autor:
Bradley T. Hyman, Gregory A. Hickey, William E. Klunk, Brian J. Bacskai, Yanming Wang, Chester A. Mathis, Jesse Skoch, Guo Feng Huang, Stephen T. Kajdasz
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12462-12467
The lack of a specific biomarker makes preclinical diagnosis of Alzheimer's disease (AD) impossible, and it precludes assessment of therapies aimed at preventing or reversing the course of the disease. The development of a tool that enables direct, q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ded588cff16e39c54e768cf8749095
https://doi.org/10.1073/pnas.2034101100
https://doi.org/10.1073/pnas.2034101100
Autor:
Brian J. Bacskai, J. D. D'Amore, Stephen T. Kajdasz, Bradley T. Hyman, Edward A. Stern, Megan E. McLellan
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 62:137-145
Postmortem analyses of senile plaques reveal numerous dystrophic processes in their vicinity. We used in vivo multiphoton microscopy of a transgenic model of Alzheimer disease (AD) to simultaneously image senile plaques and nearby neuronal processes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00aaea3a57c8a0fdefbffb2ae1710f7a
https://doi.org/10.1093/jnen/62.2.137
https://doi.org/10.1093/jnen/62.2.137
Autor:
Yanming Wang, Bradley T. Hyman, Manik L. Debnath, Daniel P. Holt, Brian J. Bacskai, William E. Klunk, Matthew P. Frosch, Guo Feng Huang, Stephen T. Kajdasz, Chester A. Mathis, Megan E. McLellan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:295-298
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe179b782c5465f7e6c92d409f66bdc
https://doi.org/10.1016/s0960-894x(01)00734-x
https://doi.org/10.1016/s0960-894x(01)00734-x
Autor:
Stephen T. Kajdasz, Bradley T. Hyman, R. H. Christie, Brian J. Bacskai, Warren R. Zipfel, Rebecca M. Williams, Watt W. Webb
Publikováno v:
Scopus-Elsevier
In Alzheimer's disease, amyloid-beta peptide aggregates in the extracellular space to form senile plaques. The process of plaque deposition and growth has been modeled on the basis of in vitro experiments in ways that lead to divergent predictions: e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5041067cf961471c53442be5e4ae6656
https://doi.org/10.1523/jneurosci.21-03-00858.2001
https://doi.org/10.1523/jneurosci.21-03-00858.2001
With the advent of transgenic mouse models expressing cortical amyloid pathology, the potential to study its progression in an intact brain has been realized. Multiphoton microscopy provides a non-destructive means of imaging with micron resolution u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac724c1fb6579b188ae9b9b745e39e3
https://doi.org/10.1385/1-59259-874-9:349
https://doi.org/10.1385/1-59259-874-9:349
Autor:
Guo-feng Huang, William E. Klunk, Jesse Skoch, Megan E. McLellan, Bradley T. Hyman, Brian J. Bacskai, Matthew P. Frosch, Chester A. Mathis, Yanming Wang, Daniel P. Holt, Stephen T. Kajdasz, Gregory A. Hickey, Manik L. Debnath
Publikováno v:
The Living Brain and Alzheimer’s Disease ISBN: 9783642639272
Senile plaques found in Alzheimer’s disease (AD) and in transgenic mouse models of AD are comprised primarily of the amyloid-β peptide. We developed an imaging technique using multiphoton microscopy to enable both detection of amyloid-β pathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03a58c7c1923537c687375dee4acfb9
https://doi.org/10.1007/978-3-642-59300-0_4
https://doi.org/10.1007/978-3-642-59300-0_4
Autor:
Bradley T. Hyman, Gregory A. Hickey, Julianne A. Lombardo, Edward A. Stern, Megan E. McLellan, Stephen T. Kajdasz, Brian J. Bacskai
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(34)
The accumulation of amyloid-β into insoluble plaques is a characteristic feature of Alzheimer's disease. Neuronal morphology is distorted by plaques: rather than being essentially straight, they are substantially more curved than those in control ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5222077091a6c300dac8225798780df9
https://pubmed.ncbi.nlm.nih.gov/14645482
https://pubmed.ncbi.nlm.nih.gov/14645482
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(6)
Amyloid-β, the primary constituent of senile plaques in Alzheimer's disease, is hypothesized to cause neuronal damage and cognitive failure, but the mechanisms are unknown. Using multiphoton imaging, we show a direct association between amyloid-β d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dbd722763d449a68e485a4a57846ae
https://pubmed.ncbi.nlm.nih.gov/12657680
https://pubmed.ncbi.nlm.nih.gov/12657680
Autor:
Brian J. Bacskai, Bradley T. Hyman, Chester A. Mathis, Matthew P. Frosch, Daniel P. Holt, Yanming Wang, Manik L. Debnath, Megan E. McLellan, William E. Klunk, Stephen T. Kajdasz
Publikováno v:
Journal of neuropathology and experimental neurology. 61(9)
The identification of amyloid deposits in living Alzheimer disease (AD) patients is important for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid therapies. Methoxy-X04 is a derivative of Congo red and Chrysamine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93879b8f48076a8c9f93e26752a22bbe
https://pubmed.ncbi.nlm.nih.gov/12230326
https://pubmed.ncbi.nlm.nih.gov/12230326
Autor:
Brian J. Bacskai, Dale B. Schenk, Megan E. McLellan, Bradley T. Hyman, Dora Games, Peter A. Seubert, Stephen T. Kajdasz
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(18)
Transgenic (Tg) mouse models overexpressing amyloid precursor protein (APP) develop senile plaques similar to those found in Alzheimer's disease in an age-dependent manner. Recent reports demonstrated that immunotherapy is effective at preventing or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e31dd4182f4ac8f22401a0d0eae4ce
https://pubmed.ncbi.nlm.nih.gov/12223540
https://pubmed.ncbi.nlm.nih.gov/12223540