Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephen T. Guest"'
Autor:
Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson, Stephen P. Ethier
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known role of 4EBP1 as a ne
Externí odkaz:
https://doaj.org/article/8b8d8c29637d4da3a5c4925419097c71
Autor:
Collin Homer-Bouthiette, Yang Zhao, Lauren B. Shunkwiler, Benjamine Van Peel, Elizabeth Garrett-Mayer, Rachael C. Baird, Anna I. Rissman, Stephen T. Guest, Stephen P. Ethier, Manorama C. John, Patricia A. Powers, Jill D. Haag, Michael N. Gould, Bart M. G. Smits
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also f
Externí odkaz:
https://doaj.org/article/b21bf55990924a71bc092663c943b4b4
Autor:
Brittany Turner-Ivey, Stephen T. Guest, Jonathan C. Irish, Christiana S. Kappler, Elizabeth Garrett-Mayer, Robert C. Wilson, Stephen P. Ethier
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 8, Pp 644-655 (2014)
The chromosome 8p11-p12 amplicon is present in 12% to 15% of breast cancers, resulting in an increase in copy number and expression of several chromatin modifiers in these tumors, including KAT6A. Previous analyses in SUM-52 breast cancer cells showe
Externí odkaz:
https://doaj.org/article/6102d9821abc4e35b73bb32c39638614
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base
Autor:
Christiana S. Kappler, Kathryn Duchinski, Joe W. Gray, Stephen P. Ethier, Kent Armeson, Robert C. Wilson, Stephen T. Guest, Elizabeth Garrett-Mayer, Daniel Couch
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-14 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Several years ago, the SUM panel of human breast cancer cell lines was developed, and these cell lines have been distributed to hundreds of labs worldwide. Our lab and others have developed extensive omics data sets from these cells. More recently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151c7a7441321ab580721b5b43996d98
https://doi.org/10.1038/s41523-020-0173-z
https://doi.org/10.1038/s41523-020-0173-z
Autor:
Patricia A. Powers, Stephen P. Ethier, Elizabeth Garrett-Mayer, Bart M. G. Smits, Jill D. Haag, Collin Homer-Bouthiette, Manorama C. John, Anna I. Rissman, Yang Zhao, Michael N. Gould, Lauren B. Shunkwiler, Benjamine Van Peel, Stephen T. Guest, Rachael C. Baird
Publikováno v:
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Background The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also frequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1605b8e5994f6950c9b609a5d8a11e1
https://doi.org/10.1186/s12885-018-5109-8
https://doi.org/10.1186/s12885-018-5109-8
Autor:
Elizabeth S. Yeh, Stephen P. Ethier, Stephen T. Guest, Kent Armeson, Alexandria Rutkovsky, Robin C. Muise-Helmericks, Victoria J. Findlay
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Background Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known role of 4EBP1 as a negative re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4217b9c30737b96377f2da312bd362ab
https://pubmed.ncbi.nlm.nih.gov/31122207
https://pubmed.ncbi.nlm.nih.gov/31122207
Publikováno v:
Experimental Cell Research. 332:223-235
Gene amplification is a common mechanism of oncogene activation in cancer. Several large-scale efforts aimed at identifying the comprehensive set of genomic regions that are recurrently amplified in cancer have been completed. In breast cancer, these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a72d72b00f0fa30ee1f7b6dc3abb54
https://doi.org/10.1016/j.yexcr.2015.02.005
https://doi.org/10.1016/j.yexcr.2015.02.005
Autor:
Stephen P. Ethier, Zachary Kratche, Ramsi Haddad, Jonathan C. Irish, Elizabeth Garrett-Mayer, Joe W. Gray, Robert C. Wilson, Stephen T. Guest
Publikováno v:
Oncotarget
// Stephen T. Guest 1 , Zachary R. Kratche 1 , Jonathan C. Irish 1 , Robert C. Wilson 1 , Ramsi Haddad 1 , Joe W. Gray 3, 4 , Elizabeth Garrett-Mayer 2 , Stephen P. Ethier 1 1 Department of Pathology and Laboratory Medicine, Hollings Cancer Center, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a553abda832164e62d75edb184010b13
https://pubmed.ncbi.nlm.nih.gov/27153554
https://pubmed.ncbi.nlm.nih.gov/27153554
Publikováno v:
Cancer Research. 77:2314-2314
Bcl-2 homology domain 3 (BH3) mimetics are a new class of targeted anti-cancer compounds that function by inducing cancer cell apoptosis. Testing in a variety of pre-clinical tumor models has shown that BH3 mimetics are capable of inducing remarkable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7baf30c9c188b494e9456b1f3e7c6079
https://doi.org/10.1158/1538-7445.am2017-2314
https://doi.org/10.1158/1538-7445.am2017-2314
Autor:
Jamie N. Mills, G Hardiam, Robert B Wilson, A Domkowski, Jon Irish, Stephen P. Ethier, Brittany Turner Ivey, Stephen T. Guest
Publikováno v:
Cancer Research. 76:P6-03
The 8p11-p12 amplicon occurs in approximately 15% of breast cancers and occurs almost exclusively in aggressive luminal B type tumors. Our lab and other labs have identified the WHSC1L1 oncogene as a driving oncogene from this region with potent tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def31f80ddf9e2873e873909094e5328
https://doi.org/10.1158/1538-7445.sabcs15-p6-03-04
https://doi.org/10.1158/1538-7445.sabcs15-p6-03-04