Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stephen T Thibault"'
Autor:
Derek E. Piper, William G. Romanow, Ruwanthi N. Gunawardane, Preston Fordstrom, Stephanie Masterman, Oscar Pan, Stephen T. Thibault, Richard Zhang, David Meininger, Margrit Schwarz, Zhulun Wang, Chadwick King, Mingyue Zhou, NigelP.C. Walker
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 9, Pp 1711-1719 (2015)
LCAT is intimately involved in HDL maturation and is a key component of the reverse cholesterol transport (RCT) pathway which removes excess cholesterol molecules from the peripheral tissues to the liver for excretion. Patients with loss-of-function
Externí odkaz:
https://doaj.org/article/b3706d7d8e0b442f9e08dfa98b04c870
Publikováno v:
BioTechniques, Vol 22, Iss 3, Pp 496-499 (1997)
We report and compare methods and apparatus for injection of pink bollworm, Pectinophora gossypiella (Saunders), embryos. Injection with an electromechanical device resulted in 59% survival of embryos. Previous techniques relying on a mechanical mani
Externí odkaz:
https://doaj.org/article/9bd7615c012f4a43b6067e23958bf1b0
Autor:
Xiaoshan Min, Sheree Johnstone, Wei Wang, Zhulun Wang, Xinchao Yu, Jennifer Weiszmann, William G. Romanow, Stephen T. Thibault, Yang Li
Publikováno v:
Journal of Biological Chemistry. 293:14678-14688
Fibroblast growth factor 21 (FGF21), an endocrine hormone in the FGF family, plays a critical role in regulating metabolic homeostasis and has emerged as a therapeutic target for metabolic diseases, including Type 2 diabetes mellitus. FGF21 functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7cbe79247186146cd43320c77ebf00
https://doi.org/10.1074/jbc.ra118.004343
https://doi.org/10.1074/jbc.ra118.004343
Autor:
William G. Romanow, Stephen T. Thibault, Preston Fordstrom, Derek E. Piper, Nigel Walker, Mingyue Zhou
Publikováno v:
Protein Expression and Purification. 125:1-6
Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the esterification of cholesterol and its subsequent incorporation into the core of high density lipoprotein (HDL) particles. It is also involved in reverse cholesterol transport (RCT), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b6a87736688c7f556297437c605466
https://doi.org/10.1016/j.pep.2015.09.003
https://doi.org/10.1016/j.pep.2015.09.003
Autor:
Zhulun Wang, David Park Meininger, Oscar Pan, Ruwanthi N. Gunawardane, Chadwick T. King, Richard Zhang, Mingyue Zhou, Stephen T. Thibault, Derek E. Piper, William G. Romanow, Nigel Walker, Preston Fordstrom, Margrit Schwarz, Stephanie Masterman
Publikováno v:
Journal of Lipid Research. 56:1711-1719
LCAT is intimately involved in HDL maturation and is a key component of the reverse cholesterol transport (RCT) pathway which removes excess cholesterol molecules from the peripheral tissues to the liver for excretion. Patients with loss-of-function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9270c529852996fdd4715ab74b29483
https://doi.org/10.1194/jlr.m059873
https://doi.org/10.1194/jlr.m059873
Autor:
Sheree Johnstone, Shawn M. Jeffries, Sujen Lai, Xiaoqi Chen, Julie Anne Heath, Zhulun Wang, Frank Kayser, Shanling Shen, Jeffrey T. Mihalic, Nigel Walker, Jeff Deignan, Wang Shen, Haoda Xu, Stephen T. Thibault, Mario G. Cardozo, Cristiano Ruch Werneck Guimarães, David J. Kopecky, Zice Fu, Xiaoshan Min, Shyun Li
Publikováno v:
Journal of Medicinal Chemistry. 55:3837-3851
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5' terminal mRNA cap structure. We designed and synthesized a series of novel compounds that displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad1e99d90e290a2390af493b4c50f25
https://doi.org/10.1021/jm300037x
https://doi.org/10.1021/jm300037x
Autor:
Xiaoshan Min, Stephen T. Thibault, Craig Uyeda, Zhulun Wang, Timothy J. Carlson, Zhihua Ma, Guifen Xu, Darin J. Gustin, Michelle Lindstrom, Frank Kayser, Yihong Li, Nigel Walker, Haoda Xu, Amy Porter
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7379-7384
Fatty acid amide hydrolase (FAAH), an amidase-signature family member, is an integral membrane enzyme that degrades lipid amides including the endogenous cannabinoid anandamide and the sleep-inducing molecule oleamide. Both genetic knock out and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ffa5f8bbec988c4bdfaf9919e7c1df
https://doi.org/10.1073/pnas.1016167108
https://doi.org/10.1073/pnas.1016167108
Publikováno v:
Transgenic Research. 20:201-214
Genetic transformation of the codling moth, Cydia pomonella, was accomplished through embryo microinjection with a plasmid-based piggyBac vector containing the enhanced green fluorescent protein (EGFP) gene. Sequencing of the flanking regions around
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bbd10e6b5c95eb222f48f68b78c9d1
https://doi.org/10.1007/s11248-010-9391-8
https://doi.org/10.1007/s11248-010-9391-8
Autor:
Bei Shan, Simon Jackson, Qiang Liu, William G. Romanow, Derek E. Piper, Nigel Walker, Stephen T. Thibault, Susan Shetterly
Publikováno v:
Structure. 15(5):545-552
SummaryProprotein convertase subtilisin kexin type 9 (PCSK9) has been shown to be involved in the regulation of extracellular levels of the low-density lipoprotien receptor (LDLR). Although PCSK9 is a subtilase, it has not been shown to degrade the L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72659780d8857c7e3556d36c59b50801
Autor:
Ross Buchholz, Jonathan Margolis, Kimberly Greer, Carol M. Singh, Lory R Tan, Lynn M Stevens, Cathy Erickson, Julie Mazzotta, Wesley Y Miyazaki, Lora Zhao, Angela Chong, Robert Fawcett, William W Fisher, Lai Man Cheung, Keith Killpack, Alex Laufer, Geoffrey Duyk, Stephen T Thibault, Candace Swimmer, Matthew A Singer, Helen Francis-Lang, Casey Kopczynski, Elizabeth Howie, Lakshmi Jakkula, Madelyn Robin Demsky, Brett Milash, Irena Zakrajsek, Richard Benn Abegania Ventura, Feng Chen, Nicholas A Dompe, Margaret L. Winberg, Alesa Woo, Lisa Ryner, Daniel Joo, Ronald D. Smith, Stephanie R Hartouni, Christiana Stuber
Publikováno v:
Nature Genetics. 36:283-287
With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout collection. The P-element transposon, the workhorse of D. melanogaster molecular genetics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790ac1443a02e6b74ca89a02a2a92ea2
https://doi.org/10.1038/ng1314
https://doi.org/10.1038/ng1314