Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephen T Joy"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009977 (2022)
The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of
Externí odkaz:
https://doaj.org/article/503f9ee3b2c74312951b0f0ccadae250
Autor:
Liam S. Sharninghausen, Sean Preshlock, Stephen T. Joy, Mami Horikawa, Xia Shao, Wade P. Winton, Jenelle Stauff, Tanpreet Kaur, Robert A. Koeppe, Anna K. Mapp, Peter J. H. Scott, Melanie S. Sanford
Publikováno v:
J Am Chem Soc
This report describes a copper-mediated radiocyanation of aryl halides that is applicable to complex molecules. This transformation tolerates an exceptionally wide range of functional groups, including unprotected amino acids. As such, it enables the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be08d788a5ab7c48e0c105d14e7ab374
https://doi.org/10.1021/jacs.2c01959
https://doi.org/10.1021/jacs.2c01959
Autor:
Isaac W Vock, Allison J L Huldin, Matthew S. Beyersdorf, Anna K. Mapp, Stephen T. Joy, Matthew J. Henley, Samantha N. De Salle
Publikováno v:
Journal of the American Chemical Society. 143:15056-15062
The protein-protein interaction between the KIX motif of the transcriptional coactivator CBP/p300 and the transcriptional activator Myb is a high-value target due to its established role in certain acute myeloid leukemias (AML) and potential contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ebbb0da5e342fc7dc19fb4928ab873
https://doi.org/10.1021/jacs.1c04432
https://doi.org/10.1021/jacs.1c04432
Publikováno v:
PLoS computational biology. 18(4)
The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b245099c9c90a7a88e20a8f8b48793
https://pubmed.ncbi.nlm.nih.gov/35452454
https://pubmed.ncbi.nlm.nih.gov/35452454
Autor:
Anna K. Mapp, Stephen T. Joy, Matthew J. Henley, I. W. Vock, A. J. L. Huldin, S. N. De Salle, M. J. Beyersdorf
The protein-protein interaction between the KIX motif of the transcriptional coactivator CBP/p300 and the transcriptional activator Myb is a high value target due to its established role in certain acute myeloid leukemias (AML) and potential contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73275b9e2dea1a315ebaa1bafd6e2e32
https://doi.org/10.1101/2021.04.28.441843
https://doi.org/10.1101/2021.04.28.441843
Autor:
Patrick Sweeney, Colleen K. Hadley, Jose Maldonado, Pauline Pan, Yijun Gui, Roger D. Cone, Masoud Ghamari-Langroudi, Richard B. Simerly, Luis E. Gimenez, Michelle N. Bedenbaugh, Griffin Downing, Anna K. Mapp, Katelyn Fowler, Stephen T. Joy, Savannah Y. Williams
Publikováno v:
Sci Transl Med
Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffb62167deb94fd9a9705c2f224179f
https://doi.org/10.1126/scitranslmed.abd6434
https://doi.org/10.1126/scitranslmed.abd6434
Publikováno v:
ACS Chem Biol
Protein-protein interactions (PPIs) play a critical role in fundamental biological processes. Competitive inhibition of these interfaces requires compounds that can access discontinuous binding epitopes along a large, shallow binding surface area. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c31d0b043e13f15a8f50000699f128
https://pubmed.ncbi.nlm.nih.gov/32378881
https://pubmed.ncbi.nlm.nih.gov/32378881
Autor:
Paramjit S. Arora, Stephen T. Joy
Publikováno v:
Chemical communications (Cambridge, England). 52(33)
Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4ae01cbb20a7becf0bebadcbf20f26
https://pubmed.ncbi.nlm.nih.gov/27046675
https://pubmed.ncbi.nlm.nih.gov/27046675
Publikováno v:
Journal of the American Chemical Society. 134:11495-11502
Oligomers composed of β(3)-amino acid residues and a mixture of α- and β(3)-residues have emerged as proteolytically stable structural mimics of α-helices. An attractive feature of these oligomers is that they adopt defined conformations in short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b4fc133695f5f415cfd05ef1a9cf07
https://doi.org/10.1021/ja301953j
https://doi.org/10.1021/ja301953j
Publikováno v:
Vascular Disease Prevention. 5:1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f61690f646d9b9ee464a50dc74043ad
https://doi.org/10.2174/156727008783503116
https://doi.org/10.2174/156727008783503116