Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stephen Sze‐Yuen Lam"'
Autor:
Bai‐Liang He, Ning Yang, Cheuk Him Man, Nelson Ka‐Lam Ng, Chae‐Yin Cher, Ho‐Ching Leung, Leo Lai‐Hok Kan, Bowie Yik‐Ling Cheng, Stephen Sze‐Yuen Lam, Michelle Lu‐Lu Wang, Chun‐Xiao Zhang, Hin Kwok, Grace Cheng, Rakesh Sharma, Alvin Chun‐Hang Ma, Chi‐Wai Eric So, Yok‐Lam Kwong, Anskar Yu‐Hung Leung
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract Internal tandem duplication of Fms‐like tyrosine kinase 3 (FLT3/ITD) occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor response to conventional treatment and adverse outcome. Here, we reported that human FLT3/
Externí odkaz:
https://doaj.org/article/7425c255c2b944118072f12994ea5710
Autor:
Cheuk Him Man, Anskar Y.H. Leung, Stephen Sze Yuen Lam, Murphy Ka Hei Sun, Howard Chun Hung Chow, Harinder Gill, Yok Lam Kwong
Publikováno v:
Blood. 122:3848-3848
Internal tandem duplication (ITD) of FLT3 (fms-like tyrosine kinase 3) in acute myeloid leukemia (AML) is associated with inferior clinical outcome. Sorafenib is effective in targeting chemo-refractory FLT3-ITD+ AML. However, leukemia progresses inva