Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stephen Skwish"'
Autor:
Jon D. Polishook, Richard G. Ball, Stephen Skwish, Karen Dorso, Gerald F. Bills, Sheo B. Singh, John W. Phillips, Marta Arocho, Emily Hickey, Michael A. Goetz, Charles Gill, Francisca Vicente, Russell Onishi, Chaowei Zhang, Suzy Lee, Deborah L. Zink, Robert G. K. Donald
Publikováno v:
The Journal of Antibiotics. 63:512-518
Bacterial resistance to antibiotics, particularly to multiple antibiotics, is becoming a cause for significant concern. The only really viable course of action to counter this is to discover new antibiotics with novel modes of action. We have recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057bad88fda8eba5302a2fd682e2c8da
https://doi.org/10.1038/ja.2010.86
https://doi.org/10.1038/ja.2010.86
Autor:
Young Whan Park, Katherine Young, John W. Phillips, Karen Dorso, Lynn Miesel, James L. Occi, Ronald E. Painter, Xin Meng, Joann Huber, Stephen Skwish, Robert G. K. Donald, Terry Roemer, Tim S. Waddell, Lisa Wang Jarantow, Russell Onishi, Sang Ho Lee, Michael J. Salvatore, Michael J. Szymonifka
Publikováno v:
Chemistry & Biology. 16(8):837-848
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial and community-acquired pathogen for which few existing antibiotics are efficacious. Here we describe two structurally related synthetic compounds that potentiate beta-lactam act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d843560a5ad702a011c874b3e1c217
Autor:
Jon D. Polishook, Jan Sigmund, Prakash S. Masurekar, Stephen Skwish, Gary S. Kath, Gerald F. Bills, Claude Dufresne, Gregory W. King, Jesús Martín, Neal Simpson, Olga Genilloud, Fernando Pelaez, S J Siciliano
Publikováno v:
SLAS Discovery. 11:704-711
Several protocols for bacterial isolation and techniques for aerobic plate counting rely on the use of a spiral plater to deposit concentration gradients of microbial suspensions onto a circular agar plate to isolate colony growth. The advantage of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ef5e465b07d352f9562aca25c02bf9
https://doi.org/10.1177/1087057106289288
https://doi.org/10.1177/1087057106289288
Publikováno v:
SLAS Discovery. 6:333-338
With the improved reliability and efficiency of automation, there has been an increased desire to integrate automated sample management with automated screening systems. In order to store samples "on line" for an extended period of time, an automatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d489855d01a9892f55b66ea0d35bb30
https://doi.org/10.1177/108705710100600507
https://doi.org/10.1177/108705710100600507
Publikováno v:
SLAS Discovery. 5:39-47
As automation solves the bottleneck involved in drug screening, new bottlenecks present themselves. Some of these bottlenecks include sample management, hit picking and confirmation, and reagents lost as a result of incomplete runs. To keep up with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9628b5908c9e8460c73258c7087522f5
https://doi.org/10.1177/108705710000500108
https://doi.org/10.1177/108705710000500108
Autor:
Scott K. Smith, Michael A. Goetz, John J. Allocco, Francisca Vicente, Deborah L. Zink, John W. Phillips, Katherine Young, Jesús Martín, Jun Lu, Ronald E. Painter, Robert G. K. Donald, Mercedes de la Cruz, Suzy Lee, Sheo B. Singh, Karen Dorso, Olga Genilloud, Jon D. Polishook, Judyann Wiltsie, Janet M. Sigmund, Russell Onishi, Karen M. Overbye, Stephen Skwish, Scott P. Salowe
Publikováno v:
Chemistrybiology. 18(8)
SummaryBacterial resistance to known therapeutics has led to an urgent need for new chemical classes of antibacterial agents. To address this we have applied a Staphylococcus aureus fitness test strategy to natural products screening. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada7293f2a58aa638b31bfe25949c31e
https://pubmed.ncbi.nlm.nih.gov/21867907
https://pubmed.ncbi.nlm.nih.gov/21867907
Autor:
Xin Meng, Jennifer W. Anderson, John W. Phillips, Jesús Martín, Liangsu Wang, Philip J. Youngman, Robert G. K. Donald, Ian Taylor, R. Allyn Forsyth, Carlos Zamudio, Colleen Burns, Stephen Skwish, Tanya Zhong, Suzy Lee, Lisa Wang Jarantow, David Robbins, Cheryl Malone, Sang Ho Lee, Lynn LoCastro
Publikováno v:
Chemistrybiology. 16(8)
SummaryThe emergence of drug-resistant bacteria coupled with the limited discovery of novel chemical scaffolds and druggable targets inspires new approaches to antibiotic development. Here we describe a chemical genomics strategy based on 245 Staphyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0bb4470a4f05bd067880d34333342
https://pubmed.ncbi.nlm.nih.gov/19716473
https://pubmed.ncbi.nlm.nih.gov/19716473
Autor:
Gregking, F.J. Asensio, Glenn A. Clarke, Stephen Skwish, Michael J. Salvatore, Gary S. Kath, Claude Dufresne
Publikováno v:
Journal of biomolecular screening. 9(8)
1 Constantly improving biological assay development continues to drive technological requirements. Recently, a specification was defined for capturing white light and fluorescent images of agar plates ranging in size from the NUNC Omni tray (96-well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81702af2ff8c2c6d173c1bb95f011252
https://pubmed.ncbi.nlm.nih.gov/15637029
https://pubmed.ncbi.nlm.nih.gov/15637029
Autor:
William Shain, Stephen Skwish
Publikováno v:
Life sciences. 47(12)
Ethanol exposure stimulates taurine release from astroglial cells. To determine if ethanol mediates this release using protein kinase C (PKC), PKC activity was measured using LRM55 astroglial cells. When ethanol (25–200 mM) or diolei (3 μM) was ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc9f0221e9822e6e738a59a7c72202d
https://pubmed.ncbi.nlm.nih.gov/2233125
https://pubmed.ncbi.nlm.nih.gov/2233125