Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephen Shang"'
Autor:
Lee, Man-Chun, Liu, Stephen Shang Yi
In this work, we study the short-time existence theory of Ricci-DeTurck flow starting from rough metrics which satisfy a Morrey-type integrability condition. Using the rough existence theory, we show the preservation and improvement of distributional
Externí odkaz:
http://arxiv.org/abs/2407.06575
Autor:
Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.
Externí odkaz:
https://doaj.org/article/5878576fa2b34029942f52a332a9c423
Autor:
Mazhar Adli, Peter C. Scacheri, Analisa Difeo, Charles N. Landen, Tarek Abbas, Philip J. Ebert, Robert M. Campbell, Inyoung Lee, Fadila Guessous, Mouadh Benamar, Natasha Lopes Fischer, Turan Tufan, Alexander James Duval, Amir A. Jazaeri, Jiekun Yang, Stephen Shang
Supplementary Figures S1-2,4, describe cell viability curves of tested cell lines. Figure S3 and S5 show bioinformatic data for resistance upregulated gene sets (S3) and cisplatin-taxane comparison analysis(S5). Figure S6 shows ECAR and OCR experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d356fc6183b02b85b38fc3cf4f861a0e
https://doi.org/10.1158/0008-5472.22422177.v1
https://doi.org/10.1158/0008-5472.22422177.v1
Autor:
Mazhar Adli, Peter C. Scacheri, Analisa Difeo, Charles N. Landen, Tarek Abbas, Philip J. Ebert, Robert M. Campbell, Inyoung Lee, Fadila Guessous, Mouadh Benamar, Natasha Lopes Fischer, Turan Tufan, Alexander James Duval, Amir A. Jazaeri, Jiekun Yang, Stephen Shang
Chemoresistance is driven by unique regulatory networks in the genome that are distinct from those necessary for cancer development. Here, we investigate the contribution of enhancer elements to cisplatin resistance in ovarian cancers. Epigenome prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2abfea44079dc54f42ebb00e725b0d
https://doi.org/10.1158/0008-5472.c.6511143.v1
https://doi.org/10.1158/0008-5472.c.6511143.v1
Publikováno v:
Nature Computational Science. 2:533-535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d4d1d47a462f1e33845fc17fd91bc7
https://doi.org/10.1038/s43588-022-00321-1
https://doi.org/10.1038/s43588-022-00321-1
Autor:
Liu, Stephen Shang Yi
Magnitude is a numerical invariant of metric spaces with origins in the notion of the Euler characteristic of a category. To this day the only convex sets in Euclidean space for which we can compute magnitude are the odd-dimensional Euclidean balls.
Autor:
Silvia Medrano, Evan A. Brown, Stephen Shang, Mazhar Adli, Turan Tufan, Maria Florencia Martinez, R. Ariel Gomez, Nadia Bertoncello, Omar Guessoum, Maria Luisa S. Sequeira-Lopez, Brian C. Belyea
Publikováno v:
Journal of Clinical Investigation. 128:4787-4803
Renin cells are crucial for survival - they control fluid-electrolyte and blood pressure homeostasis, vascular development, regeneration, and oxygen delivery to tissues. During embryonic development, renin cells are progenitors for multiple cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fede102bc966b75d003ba312405f6b03
https://doi.org/10.1172/jci121361
https://doi.org/10.1172/jci121361
Autor:
Matthew G. Mullen, Alex D. Michaels, Natasha Lopes Fischer, Mazhar Adli, P. Todd Stukenberg, Sara J. Adair, Karol Szlachta, Todd W. Bauer, Limin Liu, Stephen Shang, Turan Tufan, Edward B. Stelow, Prasad Trivedi, J. Thomas Parsons, Cem Kuscu, Jiekun Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Predicting the response and identifying additional targets that will improve the efficacy of chemotherapy is a major goal in cancer research. Through large-scale in vivo and in vitro CRISPR knockout screens in pancreatic ductal adenocarcinoma cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb41081728d7e045b180da8b88c76a7f
https://doaj.org/article/5878576fa2b34029942f52a332a9c423
https://doaj.org/article/5878576fa2b34029942f52a332a9c423
Autor:
Lei S. Qi, Augustine Chemparathy, Muneaki Nakamura, Hannah R. Kempton, Leiping Zeng, Stephen Shang, Xiaoshu Xu
Publikováno v:
Molecular Cell. 81:4333-4345.e4
Summary Compact and versatile CRISPR-Cas systems will enable genome engineering applications through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient miniature Cas system (CasMINI) engineered from the type V-F Cas1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68b6aafdadfaa47092a42ed22304147
https://doi.org/10.1016/j.molcel.2021.08.008
https://doi.org/10.1016/j.molcel.2021.08.008
Autor:
Mazhar Adli, Erin P. Harris, Jennifer T. Wolstenholme, Changqing Zhou, Philip S. Lambeth, Stephen Shang, Anne D Henriksen, Jodi A. Flaws, Catalina Montiel, Emilie F. Rissman, Zuzana Drobná
Publikováno v:
Endocrinology. 159:132-144
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes, and these effects can last for generations. We exposed embryos to BPA, producing two lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ae821441afc694c7782bf8c8d6b2f1
https://doi.org/10.1210/en.2017-00730
https://doi.org/10.1210/en.2017-00730