Zobrazeno 1 - 10
of 457
pro vyhledávání: '"Stephen S.-T. Yau"'
Autor:
Hongyu Yu, Stephen S.-T. Yau
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2083-2096 (2024)
Understanding the structural similarity between genomes is pivotal in classification and phylogenetic analysis. As the number of known genomes rockets, alignment-free methods have gained considerable attention. Among these methods, the natural vector
Externí odkaz:
https://doaj.org/article/07cdc645e42749c680175460cf766e69
Publikováno v:
The Innovation, Vol 5, Iss 5, Pp 100677- (2024)
Summary: It is important to understand the geometry of genome space in biology. After transforming genome sequences into frequency matrices of the chaos game representation (FCGR), we regard a genome sequence as a point in a suitable Grassmann manifo
Externí odkaz:
https://doaj.org/article/25dc227c20e64edca15dddc7f0b267f3
Autor:
Hongyu Yu, Stephen S.-T. Yau
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Chromosomal fusion is a significant form of structural variation, but research into algorithms for its identification has been limited. Most existing methods rely on synteny analysis, which necessitates manual annotations and always involves ineffici
Externí odkaz:
https://doaj.org/article/0d8eef245e0e482ea233b8509b4264c4
Autor:
Stephen S.-T. Yau, Qi Wu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/6bdd5645e57d496498c3d280fc96420e
Publikováno v:
Fundamental Research, Vol 1, Iss 5, Pp 559-564 (2021)
Although with the continuous development of sequencing technology, the number of genome and protein sequences has grown rapidly, these sequences are only a small part of nature. Biologically, it is still a challenging and important problem to detect
Externí odkaz:
https://doaj.org/article/1eeb57e6356544b79415289aab553600
Autor:
Nan Sun, Stephen S.-T. Yau
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Mutations may produce highly transmissible and damaging HIV variants, which increase the genetic diversity, and pose a challenge to develop vaccines. Therefore, it is of great significance to understand how mutations drive the virulence of HIV. Based
Externí odkaz:
https://doaj.org/article/503456d9121b43b1983ed175cbb536aa
Publikováno v:
PeerJ, Vol 10, p e13544 (2022)
Background The characterization and comparison of microbial sequences, including archaea, bacteria, viruses and fungi, are very important to understand their evolutionary origin and the population relationship. Most methods are limited by the sequenc
Externí odkaz:
https://doaj.org/article/d44f0450419e4c248918fc27261b741b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4226-4234 (2021)
Understanding the relationships between genomic sequences is essential to the classification and characterization of living beings. The classes and characteristics of an organism can be identified in the corresponding genome space. In the genome spac
Externí odkaz:
https://doaj.org/article/45b2cc0d19a84d7d8b40ff3be5dede53
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Protein structure can provide insights that help biologists to predict and understand protein functions and interactions. However, the number of known protein structures has not kept pace with the number of protein sequences determined by hi
Externí odkaz:
https://doaj.org/article/199937e8b1a14984ab6c0c6f66e11993
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1904-1913 (2020)
Chaos Game Representation (CGR) was first proposed to be an image representation method of DNA and have been extended to the case of other biological macromolecules. Compared with the CGR images of DNA, where DNA sequences are converted into a series
Externí odkaz:
https://doaj.org/article/cc6f390c42e64246a89b1ae80724bd85