Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Stephen S. MacKinnon"'
Autor:
Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronavi
Externí odkaz:
https://doaj.org/article/6fc7b459daf94a499be2325b0bbff79f
Autor:
Costin N. Antonescu, Bo Wang, Stephen S. MacKinnon, Vijay Shahani, Jean-Philippe Julien, Andreas Windemuth, Seyed Ali Madani Tonekaboni, Gregory D. Fairn, Sarah A. Sabatinos, Raffi Karshafian, Roberto Botelho, Andrew Haller, Russell D. Viirre, Joseph B. McPhee, Rahul Misra, Kyle Cheung, Sikander Hayat, Hassaan Maan, Edurne Rujas, Mehran Karimzadeh, Dar’ya S. Redka, Haotian Cui, Michael G. Sugiyama
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a129474d5f09baee846b06163aa1f9
https://doi.org/10.32920/21982913.v1
https://doi.org/10.32920/21982913.v1
Publikováno v:
Current Protocols. 1
Drug-Target interaction predictions are an important cornerstone of computer-aided drug discovery. While predictive methods around individual targets have a long history, the application of proteome-scale models is relatively recent. In this overview
Autor:
Edurne Rujas, Andrew Haller, Joseph B. McPhee, Roberto J. Botelho, Sarah A. Sabatinos, Mehran Karimzadeh, Bo Wang, Vijay M. Shahani, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Raffi Karshafian, Gregory D. Fairn, Sikander Hayat, Haotian Cui, Hassaan Maan, Michael G. Sugiyama, Stephen S. MacKinnon, Costin N. Antonescu, Rahul Misra, Russell D. Viirre, Kyle Cheung, Dar’ya S. Redka, Jean-Philippe Julien
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cau
Autor:
Zhaleh Safikhani, Seyed Ali Madani Tonekaboni, Stephen S. MacKinnon, Benjamin Haibe-Kains, Andreas Windemuth, Andrew E. Brereton
Publikováno v:
ICMLA
Performance of neural network models relies on the availability of large datasets with minimal levels of uncertainty. Transfer Learning (TL) models have been proposed to resolve the issue of small dataset size by letting the model train on a bigger,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f1c4fac4f0747b749afc37614c14eb
Autor:
Shoshana J. Wodak, Vijay M. Shahani, Steven Molinski, Geoffrey Woollard, Cecilia G. Sanchez, Stephen S. MacKinnon, Naheed Kurji, Leonard D. Morayniss, Andreas Windemuth, Marcon Laforet
Publikováno v:
Biochemical and Biophysical Research Communications. 483:502-508
The investigational compound BIA 10-2474, designed as a long-acting and reversible inhibitor of fatty acid amide hydrolase for the treatment of neuropathic pain, led to the death of one participant and hospitalization of five others due to intracrani
Autor:
Andrew E. Brereton, Andreas Windemuth, Shawn Reeves, Stephen S. MacKinnon, Zhaleh Safikhani, Sana Alwash, Vijay M. Shahani
Publikováno v:
Machine Learning: Science and Technology. 1:025008
The prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of small molecules from their molecular structure is a central problem in medicinal chemistry with great practical importance in drug discovery. Creating predicti
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1749)
Many functional roles have been attributed to homodimers, the most common mode of protein self-association, notably in the regulation of enzymes, ion channels, transporters and transcription factors. Here we review findings that offer new insights in
Autor:
Christine E. Bear, Onofrio Laselva, Stephen S. MacKinnon, Vijay M. Shahani, Marcon Laforet, Steven Molinski, Leonard D. Morayniss, Andreas Windemuth, Geoffrey Woollard, Adithya S. Subramanian
Publikováno v:
Proteins. 86(8)
BackgroundCystic Fibrosis (CF) is caused by mutations in the CFTR gene, of which over 2000 have been reported to date. Mutations have yet to be analyzed in aggregate to assess their distribution across the tertiary structure of the CFTR protein, an a
Autor:
Stephen S. MacKinnon, Joseph A. Lasky, Debasis Mondal, Taylor Fuselier, Steven Molinski, Rafael Gongora, Cecilia G. Sanchez, Meredith L. Sosulski
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 70(1)
Objective Transforming growth factor β1 (TGFβ1) is considered a key factor in fibrogenesis, and blocking TGFβ1 signaling pathways diminishes fibrogenesis in animal models. The objective of this study was to determine whether nelfinavir mesylate (N