Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Stephen S. Chen"'
Autor:
Sheng Hui, Josh M Silverman, Stephen S Chen, David W Erickson, Markus Basan, Jilong Wang, Terence Hwa, James R Williamson
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 2, Pp 1-15 (2015)
Abstract A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to metabolic challenges in exponentially growing Escherichia coli using mass spectrometry
Externí odkaz:
https://doaj.org/article/e80083352dca42eeb988330785bbe81f
Autor:
Rebecca S. Sippel, Kristin L. Long, Amanda R. Doubleday, Susan C. Pitt, Sarah Schaefer, David F. Schneider, Stephen S. Chen, Nick Zaborek
Publikováno v:
J Surg Res
Background After thyroidectomy, patients require Levothyroxine (LT4). It may take years of dose adjustments to achieve euthyroidism. During this time, patients encounter undesirable symptoms associated with hypo- or hyper-thyroidism. Currently, provi
Autor:
Stephen S. Chen, Gary Siuzdak, Lars Plate, Michael A. Marletta, Peter J. O'Brien, Gary J. Patti, Zheng-Jiang Zhu, Julijana Ivanisevic, Ralf Tautenhahn, Caroline H. Johnson
Publikováno v:
Analytical Chemistry. 85:6876-6884
Although the objective of any ‘omic science is broad measurement of its constituents, such coverage has been challenging in metabolomics because the metabolome is comprised of a chemically diverse set of small molecules with variable physical prope
Publikováno v:
Journal of Athletic Training. 47:519-524
Context Anterior knee pain is a common disorder in female athletes with an undefined cause. The relative prevalence of specific patellofemoral disorders associated with anterior knee pain in adolescent females remains undetermined. Objective To deter
Publikováno v:
Analytical Chemistry. 82:5038-5045
Relative levels of ribosomal proteins were quantified in crude cell lysates using mass spectrometry. A method for quantifying cellular protein levels using macromolecular standards is presented that does not require complex sample separation, identif
Autor:
Stephen S. Chen, Stephen P. Mayfield, David Siefker, Andrea L Manuell, Machiko Muto, Miller Tran, Joann Wu, Julia Marin-Navarro
Publikováno v:
Current Opinion in Biotechnology. 18:126-133
Protein-based therapeutics are the fastest growing sector of drug development, mainly because of the high sensitivity and specificity of these molecules. Their high specificity leads to few side effects and excellent success rates in drug development
Autor:
Stephen S. Chen, Susan K. Chandler
Publikováno v:
Bariatric Nursing and Surgical Patient Care. 2:65-70
Obesity ravages the central trunk. Recent advances in plastic surgery techniques after massive weight loss have demonstrated the benefit and necessity of treating the trunk as one aesthetic unit for the best possible result. This article discusses cu
Autor:
Stephen S. Chen, Markus Basan, Josh M. Silverman, James R. Williamson, Sheng Hui, David W. Erickson, Jilong Wang, Terence Hwa
Publikováno v:
Molecular Systems Biology
A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to metabolic challenges in exponentially growing Escherichia coli using mass spectrometry. Despite
Autor:
James R. Williamson, Stephen S. Chen
Publikováno v:
Journal of molecular biology. 425(4)
The ribosome is an essential and highly complex biological system in all living cells. A large body of literature on the assembly of the ribosome in vitro is available, but a clear picture of this process inside the cell has yet to emerge. Here, we d
Publikováno v:
Molecular cell. 22(4)
In nature, evolution occurs through the continuous adaptation of a population to its environment. At the molecular level, adaptive changes in protein sequence and expression impact organismal fitness and, consequently, dictate population dynamics. He