Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Stephen S Palmer"'
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid stimulating hormone (TSH) are heterodimeric proteins with a common subunit and hormone-specific subunit. These hormones are dominant regulato
Externí odkaz:
https://doaj.org/article/45eeb62a5ffa44859c25d8fab5a8df6d
Autor:
Niamh S. Sayers, Priyanka Anujan, Henry N. Yu, Stephen S. Palmer, Jaya Nautiyal, Stephen Franks, Aylin C. Hanyaloglu
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and complex pathways. Classically, FSHR activates Gαs to increase intracellular levels of cAMP,
Externí odkaz:
https://doaj.org/article/68b2b6b7698f46bb95b942fa91ee3022
Autor:
Ram K. Modukuri, Diana Monsivais, Feng Li, Murugesan Palaniappan, Kurt M. Bohren, Zhi Tan, Angela F. Ku, Yong Wang, Chandrashekhar Madasu, Jian-Yuan Li, Suni Tang, Gabriella Miklossy, Stephen S. Palmer, Damian W. Young, Martin M. Matzuk
Publikováno v:
Journal of Medicinal Chemistry. 66:2143-2160
Autor:
Francesco De Pascali, Mohammed Akli Ayoub, Riccardo Benevelli, Silvia Sposini, Jordan Lehoux, Nathalie Gallay, Pauline Raynaud, Flavie Landomiel, Frédéric Jean-Alphonse, Christophe Gauthier, Lucie P. Pellissier, Pascale Crépieux, Anne Poupon, Asuka Inoue, Nicolas Joubert, Marie-Claude Viaud-Massuard, Livio Casarini, Manuela Simoni, Aylin C. Hanyaloglu, Selva G. Nataraja, Henry N. Yu, Stephen S. Palmer, Romain Yvinec, Eric Reiter
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9850 (2021)
Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to decipher comple
Externí odkaz:
https://doaj.org/article/f144abbebe294986baabcf655018a84f
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Autor:
Niamh S, Sayers, Priyanka, Anujan, Henry N, Yu, Stephen S, Palmer, Jaya, Nautiyal, Stephen, Franks, Aylin C, Hanyaloglu
Publikováno v:
Frontiers in endocrinology. 12
Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and complex pathways. Classically, FSHR activates Gαs to increase intracellular levels of cAMP,
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Autor:
Jean-Pierre Gotteland, Deborah Denis, Stephen S. Palmer, Kevin G. Osteen, Enrico Gillio Tos, Kaylon L. Bruner-Tran, Melis Altan, Selvaraj Nataraja
Publikováno v:
Reproductive Sciences. 23:11-23
Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites. Current endocrine therapies address the estrogenic aspect of disease and offer some relief from pain but are associate
Publikováno v:
Endocrinology. 159(7)
Follicle-stimulating hormone receptor (FSHR) belongs to the leucine-rich repeat family of the G protein–coupled receptor (LGR), which includes the glycoprotein hormone receptors luteinizing hormone receptor, thyrotropin receptor, and other LGRs 4,
Autor:
Melanie S. Dugas, David J. Fischer, Selva Nataraja, Andreas Goutopoulos, Mathew Jenks, Foglesong Robert James, Henry Yu, Brian H. Heasley, Xuliang Jiang, Hui Tian, Thomas F. N. Haxell, Jane Li, Pandi Bharathi, Venkataraman Sriraman, Thomas E. Richardson, Stephen S. Palmer, Regina Collis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2168-2172
Follicle-stimulating hormone (FSH), acting on its receptor (FSHR), plays a pivotal role in the stimulation of follicular development and maturation. Multiple injections of protein formulations are used during clinical protocols for ovulation inductio