Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stephen S Gisselbrecht"'
Autor:
Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht, Sachi Inukai, Sabrina K. Phanor, James T. Anderson, Gayatri Ramakrishnan, Colin H. Lipper, Dongyuan Song, Jesse V. Kurland, Julia M. Rogers, Raehoon Jeong, Stephen C. Blacklow, Rafael A. Irizarry, Martha L. Bulyk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease-associated mutations in the Human
Externí odkaz:
https://doaj.org/article/fb03d33422b540199802faeaf082a440
Autor:
Brian W Busser, Stephen S Gisselbrecht, Leila Shokri, Terese R Tansey, Caitlin E Gamble, Martha L Bulyk, Alan M Michelson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69385 (2013)
Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors (TFs) having diverse developmental functions, often acting within the same cell types, yet many members of this family paradoxically recognize similar DNA
Externí odkaz:
https://doaj.org/article/ae3415d4afba4ec79cbd98334d7707cd
Autor:
Anthony A Philippakis, Brian W Busser, Stephen S Gisselbrecht, Fangxue Sherry He, Beatriz Estrada, Alan M Michelson, Martha L Bulyk
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 5, p e53 (2006)
While combinatorial models of transcriptional regulation can be inferred for metazoan systems from a priori biological knowledge, validation requires extensive and time-consuming experimental work. Thus, there is a need for computational methods that
Externí odkaz:
https://doaj.org/article/15a5874a0a4a422197c9547317d96a8f
Autor:
Beatriz Estrada, Sung E Choe, Stephen S Gisselbrecht, Sebastien Michaud, Lakshmi Raj, Brian W Busser, Marc S Halfon, George M Church, Alan M Michelson
Publikováno v:
PLoS Genetics, Vol 2, Iss 2, p e16 (2006)
An important but largely unmet challenge in understanding the mechanisms that govern the formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within the tissue of interest. Here
Externí odkaz:
https://doaj.org/article/d67d84d924ac42b0a755d3eb45df2677
Autor:
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/4f3047bac88542cc9b27e1ea55de683f
Autor:
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Publikováno v:
Nucleic acids research.
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML).
Autor:
Matthew Jared Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
SUMMARYWilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e94ffa9d1ea16dfa218ab882db04cc
https://doi.org/10.1101/2022.11.02.514796
https://doi.org/10.1101/2022.11.02.514796
Autor:
Colin T. Waters, Stephen S. Gisselbrecht, Yuliya A. Sytnikova, Tiziana M. Cafarelli, David E. Hill, Martha L. Bulyk
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Genome Biology
Genome Biology
Understanding the contributions of transcription factor DNA binding sites to transcriptional enhancers is a significant challenge. We developed Quantitative enhancer-FACS-Seq for highly parallel quantification of enhancer activities from a genomicall
Publikováno v:
Trends Genet
Silencers are regulatory DNA elements that reduce transcription from their target promoters; they are the repressive counterparts of enhancers. Although discovered decades ago, and despite evidence of their importance in development and disease, sile
Publikováno v:
Genome Res
Deciphering the interplay between chromatin accessibility and transcription factor (TF) binding is fundamental to understanding transcriptional regulation, control of cellular states, and the establishment of new phenotypes. Recent genome-wide chroma