Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Stephen S, Ferguson"'
Autor:
Anthony J. F. Reardon, Reza Farmahin, Andrew Williams, Matthew J. Meier, Gregory C. Addicks, Carole L. Yauk, Geronimo Matteo, Ella Atlas, Joshua Harrill, Logan J. Everett, Imran Shah, Richard Judson, Sreenivasa Ramaiahgari, Stephen S. Ferguson, Tara S. Barton-Maclaren
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The growing number of chemicals in the current consumer and industrial markets presents a major challenge for regulatory programs faced with the need to assess the potential risks they pose to human and ecological health. The increasing demand for ha
Externí odkaz:
https://doaj.org/article/96854b10d2a34e91b4c5508eac32b91d
Autor:
Alicia Y. Lim, Yuki Kato, Courtney Sakolish, Alan Valdiviezo, Gang Han, Piyush Bajaj, Jason Stanko, Stephen S. Ferguson, Remi Villenave, Philip Hewitt, Rhiannon N. Hardwick, Ivan Rusyn
Publikováno v:
Bioengineering, Vol 10, Iss 10, p 1195 (2023)
The liver is one of the key organs for exogenous and endogenous metabolism and is often a target for drug- and chemical-driven toxicity. A wide range of experimental approaches has been established to model and characterize the mechanisms of drug- an
Externí odkaz:
https://doaj.org/article/a18304e2256b45029ba33d462bd66feb
Autor:
Hongbing Wang, Paul C. Brown, Edwin C.Y. Chow, Lorna Ewart, Stephen S. Ferguson, Suzanne Fitzpatrick, Benjamin S. Freedman, Grace L. Guo, William Hedrich, Scott Heyward, James Hickman, Nina Isoherranen, Albert P. Li, Qi Liu, Shannon M. Mumenthaler, James Polli, William R. Proctor, Alexandre Ribeiro, Jian‐Ying Wang, Ronald L. Wange, Shiew‐Mei Huang
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1659-1680 (2021)
Abstract Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and si
Externí odkaz:
https://doaj.org/article/523a044f71fe468699fe3793345748a3
Autor:
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays
Externí odkaz:
https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab
Autor:
Julie K. Buick, Andrew Williams, Rémi Gagné, Carol D. Swartz, Leslie Recio, Stephen S. Ferguson, Carole L. Yauk
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-14 (2020)
Abstract Background Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In genetic toxicology, the
Externí odkaz:
https://doaj.org/article/7af746f5ce7d42ff8efd348882bc964e
Autor:
Julie K. Buick, Andrew Williams, Matthew J. Meier, Carol D. Swartz, Leslie Recio, Rémi Gagné, Stephen S. Ferguson, Bevin P. Engelward, Carole L. Yauk
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI
Externí odkaz:
https://doaj.org/article/e4d39a8558a149fc9ffab87e469ad97d
Autor:
Pierre R. Bushel, Stephen S. Ferguson, Sreenivasa C. Ramaiahgari, Richard S. Paules, Scott S. Auerbach
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Analysis of bulk RNA sequencing (RNA-Seq) data is a valuable tool to understand transcription at the genome scale. Targeted sequencing of RNA has emerged as a practical means of assessing the majority of the transcriptomic space with less reliance on
Externí odkaz:
https://doaj.org/article/c213bcc99fa140ec80b88d404a135eea
Autor:
Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker
Publikováno v:
Toxicol Sci
Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632
https://pubmed.ncbi.nlm.nih.gov/35689632
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11e5fdaa63075f6849cf55fc226e2a5
https://doi.org/10.1124/jpet.122.138300
https://doi.org/10.1124/jpet.122.138300
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a647bcea8919668465f77c1ef7984c04
https://doi.org/10.1124/jpet.122.185020
https://doi.org/10.1124/jpet.122.185020