Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephen Rundlett"'
Autor:
Sherry Boozer, Jianmin Wang, John J. Harrington, Rob Perry, Stephen Rundlett, Nancy S Wang, Anthony E. Ting, Youssef L. Bennani, Kurt R. Brunden, Joel Danzig, James T. Anderson, Amy Raber, Steven M. Murphy, Tom Dent
Publikováno v:
Journal of Medicinal Chemistry. 48:2756-2758
Analogues of the natural product noscapine were synthesized, and their potential as antitumor agents were examined. The discovery of a novel regio- and stereoselective O-demethylation led to the synthesis of several O-alkylated analogues that induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b11ad7a70507a4380122e2da2db6572
https://doi.org/10.1021/jm0494220
https://doi.org/10.1021/jm0494220
Autor:
Jianmin Wang, Laurel Faga, Joel Danzig, John J. Harrington, James T. Anderson, Anthony E. Ting, Alain Stricker-Krongrad, Kurt R. Brunden, William F. Hodnick, Youssef L. Bennani, Sherry Boozer, Robert Perry, Chris Crumrine, Stephen Rundlett, Gary Pawlowski, Amy Raber, Steven M. Murphy, Tom Dent
Publikováno v:
Journal of medicinal chemistry. 48(23)
Analogues of the natural product noscapine were synthesized and their potential as antitumor agents evaluated. The discovery of a novel regioselective O-demethylation facilitated the synthesis of the potent aniline 6, which arrests mammalian cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57984f8042e744d104354c623883ae8
https://pubmed.ncbi.nlm.nih.gov/16279766
https://pubmed.ncbi.nlm.nih.gov/16279766
Autor:
Steven M. Murphy, Bruce Sherf, Tom Dent, Daniel P. Silver, Andrew Bailey, L. Nathan Tumey, Jianmin Wang, Youssef L. Bennani, Elizabeth Ann Gleason, David C. Bom, Bayard Huck, Christina Leventhal, Sherry Boozer, John J. Harrington, Stephen Rundlett, Kurt R. Brunden
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(2)
Flap endonuclease-1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. Sensitization to DNA damaging agents is a potential method for the improvement of the therapeutic w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08a8243b9649a5bb81593f397b2a84e
https://pubmed.ncbi.nlm.nih.gov/15603939
https://pubmed.ncbi.nlm.nih.gov/15603939
Autor:
Jianmin Wang, John J. Harrington, Daniel P. Silver, Bayard Huck, Kurt R. Brunden, Christina Leventhal, Bruce Sherf, L. Nathan Tumey, Tom Dent, Steven M. Murphy, Elizabeth Ann Gleason, Andrew Bailey, Sherry Boozer, Stephen Rundlett, Youssef L. Bennani
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(19)
There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4314bdb4a4d7541f2470c537d28b002
https://pubmed.ncbi.nlm.nih.gov/15341951
https://pubmed.ncbi.nlm.nih.gov/15341951
Autor:
Kalok Lo, Neil Veloso, Kevin Cothren, Rakesh Ramachandran, Matthew D. Ducar, Laura Lerner, John J. Harrington, Emery Smith, Robert W. Mays, Joel Danzig, Dana Costanzo, Scott Cain, Christina Leventhal, P. David Jackson, Sherry Boozer, Jennifer Hess, Mark Thornton, Stephen Rundlett, Karen McElligott, Bruce Sherf, Rob Perry, Jessica Whittington, Jason Offenbacher, Alison K. Klika
Publikováno v:
Nature biotechnology. 19(5)
Here we report the use of random activation of gene expression (RAGE) to create genome-wide protein expression libraries. RAGE libraries containing only 5 x 10(6) individual clones were found to express every gene tested, including genes that are nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084c0499173b10126333d7a26b90cd46
https://pubmed.ncbi.nlm.nih.gov/11329013
https://pubmed.ncbi.nlm.nih.gov/11329013
Autor:
Selina Jain, Sally E. Kinsey, Elena Jones, Sarah L. Field, Richard A. Jones, Frederique Ponchel, Dennis McGonagle, Anne English, Robert J. Deans, Andy C. Rawstron, Stephen Rundlett, Paul Emery, Liz Strazsynski
Publikováno v:
Blood. 108:2570-2570
Gene and antigen expression profile of bone marrow MSCs in culture has been investigated, but these characteristics of MSCs in vivo are poorly understood. In this study we used microarrays to compare MSCs freshly-purified from human bone marrow aspir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34af11cadac9f9b4c51c0436b1e1cd44
https://doi.org/10.1182/blood.v108.11.2570.2570
https://doi.org/10.1182/blood.v108.11.2570.2570
Autor:
Piratheepan Suntharalingam, Sherry Boozer, Stephen Rundlett, Catherine M. Verfaillie, Robert J. Deans
Publikováno v:
Blood. 104:4261-4261
Summary The clinical utility of an ex-vivo expanded stem cell population is dependent on both safety and efficacy. As an initial step toward ensuring that expanded adult stem cell populations are safe, we harvested bone marrows from four different st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebc0932980ac78f9719b244cb86d88ee
https://doi.org/10.1182/blood.v104.11.4261.4261
https://doi.org/10.1182/blood.v104.11.4261.4261