Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Stephen R. Spellman"'
Autor:
Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D. Hoogenboom, Stephen R. Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A. A. Miranda, Alina Tanase, Liesbeth C. de Wreede, Vinzenz Lange, Alexander H. Schmidt, Jürgen Sauter, Joshua A. Fein, Yung-Tsi Bolon, Meilun He, Steven G. E. Marsh, Shahinaz M. Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor’s Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in
Externí odkaz:
https://doaj.org/article/2b878953d63c4541a7adf722c396e6d2
Autor:
Amy P. Webster, Simone Ecker, Ismail Moghul, Xiaohong Liu, Pawan Dhami, Sarah Marzi, Dirk S. Paul, Michelle Kuxhausen, Stephanie J. Lee, Stephen R. Spellman, Tao Wang, Andrew Feber, Vardhman Rakyan, Karl S. Peggs, Stephan Beck
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Allogeneic hematopoietic cell transplantation (HCT) is used to treat many blood-based disorders and malignancies, however it can also result in serious adverse events, such as the development of acute graft-versus-host disease (aGVHD). This study aim
Externí odkaz:
https://doaj.org/article/951e2cf5b5514896b6ba6afd2a1f92db
Autor:
Derek W. Brown, Weiyin Zhou, Youjin Wang, Kristine Jones, Wen Luo, Casey Dagnall, Kedest Teshome, Alyssa Klein, Tongwu Zhang, Shu-Hong Lin, Olivia W. Lee, Sairah Khan, Jacqueline B. Vo, Amy Hutchinson, Jia Liu, Jiahui Wang, Bin Zhu, Belynda Hicks, Andrew St. Martin, Stephen R. Spellman, Tao Wang, H. Joachim Deeg, Vikas Gupta, Stephanie J. Lee, Neal D. Freedman, Meredith Yeager, Stephen J. Chanock, Sharon A. Savage, Wael Saber, Shahinaz M. Gadalla, Mitchell J. Machiela
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Myelofibrosis is a risk factor for the development of Acute Myeloid Leukaemia. Here, the authors carry out an integrated genomic investigation of 933 myelofibrosis patients, and identified interactions between germline and somatic variation in patien
Externí odkaz:
https://doaj.org/article/ab44e678038343a49f55b6e7f9217d06
Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities
Autor:
Timothy S. Olson, Benjamin F. Frost, Jamie L. Duke, Marian Dribus, Hongbo M. Xie, Zachary D. Prudowsky, Elissa Furutani, Jonas Gudera, Yash B. Shah, Deborah Ferriola, Amalia Dinou, Ioanna Pagkrati, Soyoung Kim, Yixi Xu, Meilun He, Shannon Zheng, Sally Nijim, Ping Lin, Chong Xu, Taizo A. Nakano, Joseph H. Oved, Beatriz M. Carreno, Yung-Tsi Bolon, Shahinaz M. Gadalla, Steven G.E. Marsh, Sophie Paczesny, Stephanie J. Lee, Dimitrios S. Monos, Akiko Shimamura, Alison A. Bertuch, Loren Gragert, Stephen R. Spellman, Daria V. Babushok
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Acquired aplastic anemia (AA) is caused by autoreactive T cell–mediated destruction of early hematopoietic cells. Somatic loss of human leukocyte antigen (HLA) class I alleles was identified as a mechanism of immune escape in surviving hematopoieti
Externí odkaz:
https://doaj.org/article/d1c7bc07cfdf4986bc137dedb34e3f11
Autor:
Tsung-Po Lai, Simon Verhulst, Casey L. Dagnall, Amy Hutchinson, Stephen R. Spellman, Alan Howard, Hormuzd A. Katki, John E. Levine, Wael Saber, Abraham Aviv, Shahinaz M. Gadalla
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The age of allogeneic hematopoietic cell transplant (HCT) donors and their hematopoietic cell telomere length (TL) might affect recipients’ outcomes. Our goals were to examine the possible effect of these donors’ factors on the recipients’ hema
Externí odkaz:
https://doaj.org/article/4ef3d118d6194a27853028577ffb7270
Autor:
Youjin Wang, Weiyin Zhou, Lisa J. McReynolds, Hormuzd A. Katki, Elizabeth A. Griffiths, Swapna Thota, Mitchell J. Machiela, Meredith Yeager, Philip McCarthy, Marcelo Pasquini, Junke Wang, Ezgi Karaesmen, Abbas Rizvi, Leah Preus, Hancong Tang, Yiwen Wang, Loreall Pooler, Xin Sheng, Christopher A. Haiman, David Van Den Berg, Stephen R. Spellman, Tao Wang, Michelle Kuxhausen, Stephen J. Chanock, Stephanie J. Lee, Theresa E. Hahn, Lara E. Sucheston-Campbell, Shahinaz M. Gadalla
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract To improve risk stratification and treatment decisions for patients with acute myeloid leukemia (AML) undergoing hematopoietic cell transplantation (HCT). We used SNP-array data from the DISCOVeRY-BMT study to detect chromosomal aberrations
Externí odkaz:
https://doaj.org/article/e700d72e5c1b4de9b3ebf24378046514
Autor:
Paul J. Martin, David M. Levine, Barry E. Storer, Xiuwen Zheng, Deepti Jain, Ben Heavner, Brandon M. Norris, Daniel E. Geraghty, Stephen R. Spellman, Cassie L. Sather, Feinan Wu, John A. Hansen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HC
Externí odkaz:
https://doaj.org/article/d8ded45fc3324f79a80af8275498d5e9
Autor:
David Roe, Cynthia Vierra-Green, Chul-Woo Pyo, Daniel E. Geraghty, Stephen R. Spellman, Martin Maiers, Rui Kuang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/51f8ee94cd1e4e48876e486155b76f08
Autor:
David Roe, Cynthia Vierra-Green, Chul-Woo Pyo, Daniel E. Geraghty, Stephen R. Spellman, Martin Maiers, Rui Kuang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). Reported haplotype lengths range from 67 to 269 kb and contain 4 to 18 genes. The region has certain properties such as single nucleotide variation, str
Externí odkaz:
https://doaj.org/article/d2b884d1e9574da58568491cb4e10979
Autor:
Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar AbdulRazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor histocompatib
Externí odkaz:
https://doaj.org/article/e2bb6ecc1f534dd19f5da89a9961e57e