Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephen R. Schramm"'
Autor:
Debbie Jones, Nils Lonberg, Tasha Bengoechea, Debra Hudson, Dianne M. Fishwild, Susan L. Bernhard, Kay M. Higgins, Stephen R. Schramm, Robert M. Kay, Fiona A. Harding, Susan L. O'Donnell
Publikováno v:
Nature Biotechnology. 14:845-851
Human immunoglobulin transgenic mice provide a method of obtaining human monoclonal antibodies (Mabs) using conventional hybridoma technology. We describe a novel strain of human immunoglobulin transgenic mice and the use of this strain to generate m
Autor:
Stephen R. Schramm, Getachew Sequar, Lisa D. Taylor, Robert M. Kay, Kay M. Higgins, Susan L. O'Donnell, Condie E. Carmack, Cllve S. Woodhouse, Roshanak Mashayekh, Dennis Huszar, Nils Lonberg, Chlung-Chi Kuo
Publikováno v:
International Immunology. 6:579-591
We have generated transgenic mice that contain human-sequence Ig miniloci and, because they are also homozygous for a targeted disruption of their endogenous heavy chain genes, must rely on the transgene sequences for B cell receptor expression. Alth
Autor:
Condie E. Carmack, Nils Lonberg, Kay M. Higgins, Roshanak Mashayekh, Robert M. Kay, Lisa D. Taylor, Chiung-Chi Kuo, Stephen R. Schramm, Clive S. Woodhouse
Publikováno v:
Nucleic Acids Research. 20:6287-6295
We have generated transgenic mice that express a diverse repertoire of human sequence immunoglobulins. The expression of this repertoire is directed by light and heavy chain minilocus transgenes comprised of human protein coding sequences in an unrea
Autor:
Avidan Rose, John Q. Trojanowski, Chris Paszty, Jean E.S. Pierce, Stephen R. Schramm, Jeanne F. Loring, Tracy K. McIntosh, Hisayuki Murai, Kathryn Wymore, Kenneth R. Peterson, Virginia M.-Y. Lee
Publikováno v:
Neurobiology of aging. 17(2)
A major obstacle to understanding the pathogenesis of Alzheimer's disease is the lack of easily studied animal models. Our approach is to apply transgenic methods to humanize mice and rats, employing methods that introduce large genomic transgenes, b
Autor:
Lisa D. Taylor, Kathryn Wymore, Condie E. Carmack, Chiung-Chi Kuo, Susan L. O'Donnell, Tasha Bengoechea, Roshanak Mashayekh, Dianne M. Fishwild, Donna Munoz-O'Regan, Elizabeth S. G. Lapachet, James G. McCabe, Dennis Huszar, Robert M. Kay, Fiona A. Harding, Mary Trounstine, Kay M. Higgins, Nils Lonberg, Stephen R. Schramm
Publikováno v:
Nature. 368(6474)
Human sequence monoclonal antibodies, which in theory combine high specificity with low immunogenicity, represent a class of potential therapeutic agents. But nearly 20 years after Kohler and Milstein first developed methods for obtaining mouse antib