Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stephen R. Petteway"'
Publikováno v:
Thrombosis and Haemostasis. 100:413-419
A simplified and fully functional deletion mutant of plasminogen was created in which the middle portion of the molecule was removed, resulting in kringle 1 attachment to the serine protease domain. This recombinant plasminogen deletion mutant, Delta
Publikováno v:
Transfusion Medicine Reviews. 20:57-62
Protein products isolated from human plasma are an important class of therapeutics that are used to treat patients afflicted with hereditary deficiencies, trauma, and severe infections. Because of the human origin of the starting material for the pro
Autor:
Christopher J. Stenland, Stephen R. Petteway, Michèle M. Kislan, Mark S. Nelson, Dominique Pifat, Jeanette L.C. Miller, Randal C. Hartwell, Kang Cai
Publikováno v:
Journal of Virological Methods. 125:187-193
Specific detection of the pathogenic prion protein, PrP(Sc), is essential for determining the prion clearance capacity of purification processes for therapeutic proteins. Use of a previously described indirect (two-antibody) Western blot assay someti
Autor:
Christopher J. Stenland, Richard Rubenstein, Terry Jarrett C, Rosemary B. Evans-Storms, Douglas C. Lee, Stephen R. Petteway, Kevin J. Gilligan, Jeanette L.C. Miller, Randal C. Hartwell, Kang Cai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1597:28-35
The misfolded isoform of the prion protein (PrP(Sc)) possesses many unusual physiochemical properties. Previously, we and others reported on the differential partitioning of PrP(Sc) from plasma derived therapeutic proteins during their purification p
Autor:
Michael Fournel, Douglas C. Lee, Stephen R. Petteway, Kevin J. Gilligan, Kang Cai, Terry Jarrett C, Elizabeth K. Ford, Richard Rubenstein, Randal C. Hartwell, Jeanette L.C. Miller, Christopher J. Stenland
Publikováno v:
Transfusion. 41:449-455
BACKGROUND: Experimental evidence from rodent models indicates that blood can contain transmissible spongiform encephalopathy (TSE) infectivity, which suggests a potential risk for TSE transmission via proteins isolated from human plasma. Because met
Autor:
Christopher J. Stenland, Elizabeth K. Ford, Michael Fournel, Stephen R. Petteway, Kevin J. Gilligan, Randal C. Hartwell, Richard Rubenstein, Douglas C. Lee, Jeanette L.C. Miller, Kang Cai
Publikováno v:
Journal of Virological Methods. 84:77-89
Determining the risk of transmissible spongiform encephalopathy (TSE) transmission by blood or plasma-derived products requires sensitive and specific assays for the detection of either infectivity or a reliable marker for infectivity. To this end, a
Autor:
A.L. Lambert, D E Davis, J. Erickson, Shawn O'Lin Barney, Stephen R. Petteway, T. Bucy, R. Medinas, D M Lambert, G. Merutka, K. Guthrie
Publikováno v:
Proceedings of the National Academy of Sciences. 93:2186-2191
The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1 (HIV-1) transmembrane (TM) protein, gp4l, are stable and potent inhibitors of HIV-1 infection and fusion. Using a computer s
Autor:
Teresa B. Bucy, Mary K. Lawless, Shawn Barney, Merutka Gene, Kelly I. Guthrie, and Stephen R. Petteway
Publikováno v:
Biochemistry. 35:13697-13708
Two synthetic peptides corresponding to sequences in HIV-1LAI gp41, (aa558-595) and T20 (aa 643-678), are strong inhibitors of HIV-1 viral fusion, having EC50 values of 1 microgram/mL and 1 ng/mL, respectively. Previous work suggested that T21 forms
Publikováno v:
Production of Plasma Proteins for Therapeutic Use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae569adfe2a87d4555a521e4097e9850
https://doi.org/10.1002/9781118356807.ch18
https://doi.org/10.1002/9781118356807.ch18
Autor:
Victor J. Marder, Constantinos P. Tsipis, Valery Novokhatny, Philip Scuderi, Vikram Arora, R. Christian Crumrine, G McLeod Taylor, Joseph C. LaManna, Stephen R. Petteway
Publikováno v:
Experimental & Translational Stroke Medicine
Crumrine, R; Marder, Victor J; Taylor, G; LaManna, Joseph C; Tsipis, Constantinos P; Novokhatny, Valery; et al.(2012). Safety evaluation of a recombinant plasmin derivative lacking kringles 2-5 and rt-PA in a rat model of transient ischemic stroke. Experimental & Translational Stroke Medicine, 4(1), 10. doi: http://dx.doi.org/10.1186/2040-7378-4-10. Retrieved from: http://www.escholarship.org/uc/item/5mp698wn
Crumrine, R; Marder, Victor J; Taylor, G; LaManna, Joseph C; Tsipis, Constantinos P; Novokhatny, Valery; et al.(2012). Safety evaluation of a recombinant plasmin derivative lacking kringles 2-5 and rt-PA in a rat model of transient ischemic stroke. Experimental & Translational Stroke Medicine, 4(1), 10. doi: http://dx.doi.org/10.1186/2040-7378-4-10. Retrieved from: http://www.escholarship.org/uc/item/5mp698wn
BackgroundTissue type plasminogen activator is the only approved thrombolytic agent for the treatment of ischemic stroke. However, it carries the disadvantage of a 10-fold increase in symptomatic and asymptomatic intracranial hemorrhage. A safer thro