Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephen R. Koch"'
Autor:
Ryan J. Stark, Stephen R. Koch, Cody L. Stothers, Allison Pourquoi, Celia K. Lamb, Michael R. Miller, Hyehun Choi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/3aa0576060f547d7b01de03581fd1f3c
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propagation of the inflamm
Externí odkaz:
https://doaj.org/article/2e8d5db52e7e4afb91c363d0a618267c
Autor:
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Jeffrey C. Rohrbough, Stephen R. Koch, Naoko Boatwright, Michael T. Yarboro, Rajan Sah, W. Hayes McDonald, J. Jeffrey Reese, Ryan J. Stark, Fred S. Lamb
Publikováno v:
bioRxiv
BackgroundIn vascular smooth muscle cells (VSMCs), LRRC8A volume regulated anion channels (VRACs) are activated by inflammatory and pro-contractile stimuli including tumor necrosis factor alpha (TNFα), angiotensin II and stretch. LRRC8A physically a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e108f7166a43d24fef9ab5f837719d
https://doi.org/10.1101/2023.03.08.531807
https://doi.org/10.1101/2023.03.08.531807
Publikováno v:
Transl Res
Sepsis represents a life-threatening event often mediated by the host’s response to pathogens such as gram-negative organisms, which release the pro-inflammatory lipopolysaccharide (LPS). Within the endothelium, the mitogen-activated protein kinase
Autor:
Stephen R. Koch, Ryan J. Stark
Publikováno v:
Tissue Barriers
Delivery of cargo to cells through the use of cell-penetrating peptide (CPP) sequences is an area of rich investigation for targeted therapeutics. Specific to the endothelium, the layer of cells that cover every blood vessel in the body, the loss or
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propagation of the inflammatory rea
Autor:
Benjamin A. Fensterheim, Edward R. Sherwood, Ryan J. Stark, Stephen R. Koch, Fred S. Lamb, Hyehun Choi
Publikováno v:
Clinical Science. 130:451-461
Prior exposure to lipopolysaccharide (LPS) produces a reduced or “tolerant” inflammatory response to subsequent challenges with LPS, however the potent pro-inflammatory effects of LPS limit its clinical benefit. The adjuvant monophosphoryl lipid
Publikováno v:
Innate Immunity. 21:565-574
Monophosphoryl lipid A (MPLA) is a TLR4 agonist that is used as an immunomodulator in human vaccines; additionally, it has been shown to be protective in models of sepsis. As endothelial cells regulate inflammation, we hypothesized that MPLA would de
Autor:
Sergey Dikalov, Eric H. Mace, Stephen R. Koch, Ryan J. Stark, Edward R. Sherwood, Hyehun Choi, Fred S. Lamb
Endothelial dysfunction, characterized by changes in eNOS, is a common finding in chronic inflammatory vascular diseases. These states are associated with increased infectious complications. We hypothesized that alterations in eNOS would enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e65a32380094bb6b6dd12cc62ff506f
https://europepmc.org/articles/PMC5888395/
https://europepmc.org/articles/PMC5888395/
Repeated challenge of lipopolysaccharide (LPS) alters the response to subsequent LPS exposures via modulation of toll-like receptor 4 (TLR4). Whether activation of other TLRs can modulate TLR4 responses, and vice versa, remains unclear. Specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6751d25a2d508e0edc56273997f097f7
https://escholarship.org/uc/item/9085r4xs
https://escholarship.org/uc/item/9085r4xs