Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Stephen R. James"'
Publikováno v:
Indian Journal of Endocrinology and Metabolism, Vol 20, Iss 5, Pp 656-661 (2016)
Background: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. Aim: Thi
Externí odkaz:
https://doaj.org/article/decfb106c9444cf695097e4d3c64a719
Publikováno v:
Pain Medicine. 12:808-822
Objectives. Chronic neuropathic pain has been an enigma to physicians and researchers for decades. A better understanding of its pathophysiology has given us more insight into its various mechanisms and possible treatment options. We now have an unde
Autor:
Stephen R. James
Publikováno v:
Vehicle System Dynamics. 43:581-599
A motorcycle towing a single-wheel trailer may provide useful transport for light cargo on narrow tracks and off-road use, particularly in rural areas of developing countries. Four designs of such trailers are described. Linear models are derived for
Autor:
Stephen R. James
Publikováno v:
Vehicle System Dynamics. 38:1-22
An instrumented offroad motorcycle was run at a range of speeds in approximately straight lines whilst the rider excited its lateral dynamics by shaking the steering. Autoregressive models were fitted to the resulting multiple output time series data
Autor:
Matilda Katan, Roger L. Williams, C. Peter Downes, Olga Perisic, Stephen R. James, Moira V. Ellis
Publikováno v:
Journal of Biological Chemistry. 273:11650-11659
Structural studies of phospholipase C δ1 (PLCδ1) in complexes with the inositol-lipid headgroup and calcium identified residues within the catalytic domain that could be involved in substrate recognition, calcium binding, and catalysis. In addition
Autor:
Mhairi C. Towler, John M. Lucocq, John James, Sreenivasan Ponnambalam, D.M. Hickinson, Stephen R. James, S. Clough, C.P. Downes
Publikováno v:
University of St Andrews CRIS
The eukaryotic trans-Golgi network (TGN) is a key site for the formation of transport vesicles destined for different intracellular compartments [1]. A key marker for the mammalian TGN is TGN38/46 [2]. This integral membrane glycoprotein cycles betwe
Publikováno v:
Biochemical Journal. 314:917-921
The properties of three different β-isoforms of phospholipase C (PLC) were analysed using substrate lipids dispersed in phospholipid vesicles, phospholipid–detergent mixed micelles and phospholipid monolayers spread at an air–water interface. Ph
Publikováno v:
Journal of Biological Chemistry. 270:11872-11881
Phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5)P2) hydrolysis by three different β-isoforms of phospholipase C (PLC) was examined to investigate the catalytic action of these extracellular signal-regulated enzymes. Depletion of phospholipase C f
Publikováno v:
Biochemical Journal. 304:359-364
By contrast with mammalian beta-adrenergic receptors, the avian isoform elicits two distinct effector responses, activation of adenylate cyclase and polyphosphoinositide-specific phospholipase C (PLC) leading to the accumulation of both cyclic adenos
Publikováno v:
Journal of Biological Chemistry. 269:16525-16528
Thrombin activates phosphoinositide 3-kinase (PI 3-kinase) in platelets via a mechanism involving G-proteins, possibly of both the heterotrimeric and the low molecular weight families. We have investigated the regulation of PI 3-kinase present in pla