Výsledky vyhledávání - "Stephen R. Humble"

Akademický článek

Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis. [version 2; referees: 2 approved]

Autor: Stephen R. Humble

Publikováno v: F1000Research, Vol 6 (2018)

Background: Recent work in a model of diabetic neuropathy revealed that layer 2/3 cortical pyramidal neurones of the pain pathway exhibited reduced endogenous neurosteroid modulation of the GABAAR and exogenously applied neurosteroids had an exaggera

Externí odkaz: https://doaj.org/article/57d6b2eee6ea473f8915cb90eb3cbb8c

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Akademický článek

Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain [version 1; referees: 1 approved, 2 approved with reservations]

Autor: Stephen R. Humble

Publikováno v: F1000Research, Vol 5 (2016)

Introduction: Peripheral and central sensitisation are implicated in the development of neuropathic pain. Hypersensitivity of pain pathway neurons has been described in animal models of diabetic neuropathy, which is postulated to be related to an imb

Externí odkaz: https://doaj.org/article/67d49c7aa6d147b7aa83f615e8c7206c

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Best practice in radiofrequency denervation of the lumbar facet joints: a consensus technique

Autor: Neil Collighan, Sailesh Mishra, Martin Underwood, Tacson Fernandez, Mohjir Baloch, Piotr Buczkowski, Saz Snidvongs, Ashish Gulve, Stephen R. Humble, Frank J P M Huygen, Sundar Muthukrishnan, Anisah Tariq, S. Nath, Vivek Mehta, Ann-Katrin Fritz, Rokas Tamosauskas, Murali Krishnan, Sam Eldabe, Hugh Antrobus

Publikováno v: Br J Pain
British Journal of Pain, 14(1), 47-56. SAGE Publications Ltd

Background: Radiofrequency denervation is used to treat selected people with low back pain. Recent trials have been criticised for using a sub-optimal intervention technique. Objectives: To achieve consensus on a best practice technique for administe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc5ffc1d7afedd06183a5c5afd91166
https://doi.org/10.1177/2049463719840053

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Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable

Autor: Asantha Jayaweera, Stephen R. Humble, Arun Bhaskar, Nicolas Varela

Publikováno v: Current Opinion in Supportive & Palliative Care. 12:118-123

Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234a71d02e030eb2f04ef04c52bc4fb
https://doi.org/10.1097/spc.0000000000000341

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Plasticity in somatic receptive fields after nerve injury

Autor: Stephen R. Humble

Publikováno v: Oxford Medicine

Devor and Wall, in a pioneering electrophysiological study, examined the change in somatic receptive fields in the dorsal horn of the spinal cord after nerve injury. Rather than the anticipated loss of an area of electrophysiological perception, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5076a68f09881e26caffbc1784daff5c
https://doi.org/10.1093/med/9780198834359.003.0023

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A national survey of pain clinics within the United Kingdom and Ireland focusing on the multidisciplinary team and the incorporation of the extended nursing role

Autor: Pungavi Kailainathan, Stephen R. Humble, Fiona Cameron, Shyam Gokani, Helen Dawson, Gursimren Lidder

Publikováno v: British journal of pain. 12(1)

Inconsistencies in the availability and quality of pain service provision have been noted nationally, as have lengthy waiting times for appointments and lack of awareness of the Pain Clinic role. The 2013 NHS England report stated that specialist pai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee87bcaa9927f58935812a68445551
https://pubmed.ncbi.nlm.nih.gov/29416864

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Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain

Autor: Stephen R. Humble

Publikováno v: F1000Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882dadb08e75ac8ab0115d7712cdee12
http://hdl.handle.net/10044/1/56137

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New opioid side effects and implications for long-term therapy

Autor: A.D. Harvey, Stephen R. Humble, S. Raghavan

Publikováno v: Trends in Anaesthesia and Critical Care. 1:18-21

Summary Opioids are the foundation for the treatment of acute pain and cancer pain. Their popularity in the chronic pain setting has waxed and waned over the years but there has been a recent resurgence in their use. Opioid induced side effects such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34024ac3f29ad5bc1a970f4bfc86e429
https://doi.org/10.1016/j.cacc.2010.06.003

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Calcitonin for acute neuropathic pain associated with spinal cord injury

Autor: Stephen R. Humble

Publikováno v: Anaesthesia and intensive care. 39(4)

Neuropathic pain associated with spinal cord injury is caused by complex neural mechanisms and is often refractory to standard therapy. Salmon calcitonin was an effective treatment for neuropathic symptoms in this case series of three patients with r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325135520c7a9a82a141c124e5701e1b
https://pubmed.ncbi.nlm.nih.gov/21823391

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