Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Stephen R. Dueker"'
Autor:
Anhye Kim, Stephen R. Dueker, Jun Gi Hwang, Jangsoo Yoon, Sang‐Won Lee, Hye Suk Lee, Byung‐Yong Yu, Kyung‐Sang Yu, Howard Lee
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 231-238 (2021)
The absorption, metabolism, and excretion (AME) profiles of KD101, currently under clinical development to treat obesity, were assessed in humans using accelerator mass spectrometry (AMS) after a single oral administration of KD101 at 400 mg and a mi
Externí odkaz:
https://doaj.org/article/6dc99301cee243abbd363fefaae288be
Absorption and retinol equivalence of β-carotene in humans is influenced by dietary vitamin A intake
Autor:
Shawna L. Lemke, Stephen R. Dueker, Jennifer R. Follett, Yumei Lin, Colleen Carkeet, Bruce A. Buchholz, John S. Vogel, Andrew J. Clifford
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 8, Pp 1591-1600 (2003)
The effect of vitamin A supplements on metabolic behavior of an oral tracer dose of [14C]β-carotene was investigated in a longitudinal test-retest design in two adults. For the test, each subject ingested 1 nmol of [14C]β-carotene (100 nCi) in an e
Externí odkaz:
https://doaj.org/article/27ddc422992d4cbf9db7b7762290c7ab
Autor:
Stephen R. Dueker, Yumei Lin, Bruce A. Buchholz, Phillip D. Schneider, Michael W. Lamé, H.J. Segall, John S. Vogel, Andrew J. Clifford
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1790-1800 (2000)
We present a sensitive tracer method, suitable for in vivo human research, that uses β-[14C]carotene coupled with accelerator mass spectrometry (AMS) detection. Using this approach, the concentration-time course of a physiological (306 μg; 200 nCi)
Externí odkaz:
https://doaj.org/article/8757ef14ba17496e960e81c50332a890
Autor:
Oliver Langer, Jinho Song, Min Sun Choi, Edith Lackner, Felix Bergmann, Chang Su Yeo, Miwha Kwon, Mihye Kwon, Jae Hoon Shim, Stephen R Dueker, Markus Zeitlinger, Martin Bauer
Publikováno v:
Bioanalysis. 14:1111-1122
Background: Microdialysis sampling after drug microdosing may provide tissue pharmacokinetic data early in clinical drug development. However, low administered doses and small sample volumes pose an analytical challenge, particularly for highly prote
Autor:
Nicole A Kratochwil, Stephen R Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Byung-Yong Yu, Gwan-Ho Lee, Feng Dong, Michael B Otteneder
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205435 (2018)
New therapeutic biological entities such as bispecific antibodies targeting tissue or specific cell populations form an increasingly important part of the drug development portfolio. However, these biopharmaceutical agents bear the risk of extensive
Externí odkaz:
https://doaj.org/article/70e3f7315e4d4e4089b0a39872bc2784
Publikováno v:
Bioanalysis. 12:87-98
Aim: Human 14C radiotracer studies provide information-rich data sets that enable informed decision making in clinical drug development. These studies are supported by liquid scintillation counting after conventional-sized 14C doses (50–200 μCi) o
Autor:
Stephen R. Dueker
Publikováno v:
Yakhak Hoeji. 60:163-172
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S34
Autor:
Rebecca Baillie, Priscilla Pegis, Herbert Vasquez, Gordon G. Power, Stephen R. Dueker, Le T. Vuong, Arlin B. Blood, Saira Abidi, Andrew O. Hopper, Toufigh Gordi
Publikováno v:
The Journal of Clinical Pharmacology. 54:1031-1037
Pharmacokinetic studies in the neonatal population are often limited by the small volume of blood that can be collected. The high sensitivity of (14) C-accelerator mass spectrometry (AMS) enables pharmacokinetic studies to be conducted with greatly r
Autor:
Peter N. Lohstroh, Donald Jung, Luis Lopez-Lazaro, Stephen R. Dueker, Lawrence Fleckenstein, Xin-Ping Fang, Mark Baker, Jangsik Shin, Carrie A. Morris, Li-Quan Wang, Rolf Pokorny, Stephan Duparc, Isabelle Borghini-Fuhrer
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 40:75-86
This was a single dose mass balance and metabolite characterization study of the antimalarial agent pyronaridine. Six healthy male adults were administered a single oral dose of 720 mg pyronaridine tetraphosphate with 800 nCi of radiolabeled (14)C-py