Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stephen R. Donahue"'
Publikováno v:
Clinical Therapeutics. 30:1658-1666
The serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor likely plays a critical role in anxiety pathophysiology.In this proof-of-concept investigation, we tested the short-term tolerability of PRX-00023, a nonazapirone 5-HT1A selective partial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f24ffe8427b2845822532963e6f339a
https://doi.org/10.1016/j.clinthera.2008.09.006
https://doi.org/10.1016/j.clinthera.2008.09.006
Autor:
Stephen R. Donahue, Karl Rickels, Michael Kauffman, Sanjay J. Mathew, Ganesh R. Iyer, Daniel L. Zimbroff, John F. Reinhard, Michael D. Banov, Edward C. Parsons, Scott Oshana
Publikováno v:
Journal of Clinical Psychopharmacology. 28:235-239
PRX-00023, a serotonin 1A receptor agonist, was designed to provide high potency and selectivity for its target. To assess the possible therapeutic utility in anxiety, a randomized, double-blind, placebo-controlled trial was conducted in 311 subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63486239b449e01f9d260328d179660
https://doi.org/10.1097/jcp.0b013e31816774de
https://doi.org/10.1097/jcp.0b013e31816774de
Autor:
Darrell R. Abernethy, Carol Braun Trapnell, Jerry M. Collins, Stephen R. Donahue, DA Flockhart, David L. Thacker
Publikováno v:
Clinical Pharmacology & Therapeutics. 64:597-602
To evaluate the effect of thalidomide on the plasma pharmacokinetics of ethinyl estradiol (INN, ethinylestradiol) and norethindrone (INN, norethisterone).Ten women who had undergone surgical sterilization were enrolled in an open-label crossover stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4140698c84cec6e38b36810c2e1752
https://doi.org/10.1016/s0009-9236(98)90050-9
https://doi.org/10.1016/s0009-9236(98)90050-9
Autor:
Kelly Connolly, Dominic Picarella, John J. Byrnes, Courtney Ellard, Stefan Gross, Stephen R. Donahue
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 58(11)
Angiotensin-converting enzyme 2 (ACE2) is expressed in gastrointestinal tissue. Previous studies of GL1001, a potent and selective ACE2 inhibitor, have revealed anti-inflammatory activity in the mouse digestive tract. We hypothesized that GL1001 migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de60617458b7c8c038a88dad57e5ec8f
https://pubmed.ncbi.nlm.nih.gov/19517214
https://pubmed.ncbi.nlm.nih.gov/19517214
Autor:
John J. Byrnes, Stefan B. Gross, Courtney Ellard, Dominic Picarella, Stephen R. Donahue, Carri A. Boiselle, Leanne K. Bourque, Luz-Maria Guzman, Shobu Odate
Publikováno v:
Gastroenterology. 136:A-246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a021ef9e283c77cad280e6dc78357c81
https://doi.org/10.1016/s0016-5085(09)61115-x
https://doi.org/10.1016/s0016-5085(09)61115-x
Publikováno v:
Developmental neuroscience. 12(3)
Synthesis of complex glycosphingolipids was analyzed in cultures of PC12 cells treated with nerve growth factor (NGF) and forskolin, either sequentially or simultaneously. For the sequential treatment, forskolin was added following 15 days of NGF tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a81d58547096fd95f3b10ef30dc8ca
https://pubmed.ncbi.nlm.nih.gov/2364894
https://pubmed.ncbi.nlm.nih.gov/2364894
Autor:
Stephen R. Donahue, Jean T. Barbey
Publikováno v:
JAMA: The Journal of the American Medical Association. 277:518
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8c82568df23b988e2a8b61b84cf6ca
https://doi.org/10.1001/jama.1997.03540310016009
https://doi.org/10.1001/jama.1997.03540310016009
Autor:
Thorir D. Bjornsson, John A. Wagner, Stephen R. Donahue, Dawn Harper, Aziz Karim, Marlene S. Khouri, William R. Murphy, Kristin Roman, Dennis Schneck, Daryl S. Sonnichsen, Dennis J. Stalker, Stephen D. Wise, Stuart Dombey, Caroline Loew
Publikováno v:
Journal of Clinical Pharmacology; Sep2003, Vol. 43 Issue 9, p943-967, 25p
Publikováno v:
Archives of Histology and Cytology. 52:209-216
Many strains of rats develop adrenal medullary hyperplasia and/or neoplasia after chronic administration of a wide variety of pharmacologic agents. The same changes may occur spontaneously in the course of aging. Current evidence suggests that chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b428c1d3b043c638332ffe694cc00eb
https://doi.org/10.1679/aohc.52.suppl_209
https://doi.org/10.1679/aohc.52.suppl_209
Publikováno v:
Journal of Biological Chemistry. 263:13983-13986
Lithium perturbs intracellular signal transduction pathways used by neurotransmitters, suggesting that changes in receptor signalling may underlie its actions in the treatment of manic depressive illness. Little attention, however, has been directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f315f5c7b4a93f86556bf5851334ccc
https://doi.org/10.1016/s0021-9258(18)68172-4
https://doi.org/10.1016/s0021-9258(18)68172-4