Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Stephen R. Byrn"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 42 (2023)
Levothyroxine tablets, although highly prescribed in the United States, have been one of the most frequently recalled products. Because of the importance of the medication, several efforts have been put in place by the United States Food and Drug Adm
Externí odkaz:
https://doaj.org/article/861d542477f643cb9f266c88c605d522
Autor:
Matthias Zeller, Susan Bogdanowich-Knipp, Pamela Smith, Dale K. Purcell, Mercy Okezue, Daniel T. Smith, Stephen R. Byrn, Kari L. Clase
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 4, Pp 433-445 (2021)
Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crys
Externí odkaz:
https://doaj.org/article/d45a7ace9c4f4e67acbd8d31eababc74
Autor:
Mercy A. Okezue, Stephen R. Byrn
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 257 (2023)
Bedaquiline has been approved as a combination therapy to treat multi-drug-resistant tuberculosis in adults ≥ 18 years old. The citrate, fumarate, phosphate, and tartrate salts have obtained patents, but the structures for these moieties have not b
Externí odkaz:
https://doaj.org/article/cca1d8c153804efda75ebe00f762cc9f
Autor:
Matthias Zeller, Gabriel Lima Barros de Araujo, Trev Parker, Amrinder Singh Rai, Stephen R. Byrn
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 3, Pp 417-422 (2017)
Afatinib (systematic name: N-{4-(3-chloro-4-fluoroanilino)-7-[(tetrahydrofuran-3-yl)oxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide), is a specific inhibitor of the ErbB family of tyrosine kinases. The free base form crystallizes from acetonitril
Externí odkaz:
https://doaj.org/article/360ecfbe316047b0aa69613e179840c5
Publikováno v:
Journal of Pharmaceutical Sciences. 110:2789-2799
Poly (ethylene oxide) (PEO) has been widely used in abuse-deterrent formulations (ADFs) to increase tablet hardness. Previous studies have shown that formulation variables such as processing conditions and particle size of PEO can affect ADF performa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f386eeb98f8889ffdd6824560e87f26c
https://doi.org/10.1016/j.xphs.2021.03.008
https://doi.org/10.1016/j.xphs.2021.03.008
Autor:
Daniel T. Smith, Mercy Okezue, Kari Clase, Dale K. Purcell, Pamela Smith, Stephen R. Byrn, Matthias Zeller, Susan Bogdanowich-Knipp
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 4, Pp 433-445 (2021)
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 4, Pp 433-445 (2021)
The single-crystal structures of several maleate salt of bedaquiline, a drug used for the treatment of drug-resistant tuberculosis (TB), are described.
Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosi
Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5c06424bd92558826ab088d2261564
https://doi.org/10.1107/s2056989021002991
https://doi.org/10.1107/s2056989021002991
Autor:
Stephen R. Byrn, Susan Bogandowich-Knipp, Kari Clase, Pamela Smith, Dale K. Purcell, Matthias Zeller, Mercy Okezue, Daniel W. Smith
Publikováno v:
Acta Crystallographica. Section C, Structural Chemistry
The single-crystal structures of three salts of bedaquiline, a drug used for the treatment of drug-resistant tuberculosis (TB), are described.
Bedaquiline [systematic name: 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthal
Bedaquiline [systematic name: 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbecf2c8abf5dfcbe98a2da7d0395393
http://europepmc.org/articles/PMC7642769
http://europepmc.org/articles/PMC7642769
Autor:
Salma Salem, Stephen R. Byrn, Daniel Smith, Vadim J. Gurvich, Stephen W. Hoag, Feng Zhang, Robert O. Williams III, Kari L. Clase
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb6872fb9b2edce47911cf8cb6fc83c
https://doi.org/10.2139/ssrn.4019138
https://doi.org/10.2139/ssrn.4019138
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd7cfc34edb2fbc922aa8efa00855ab
https://doi.org/10.2139/ssrn.4257827
https://doi.org/10.2139/ssrn.4257827
Publikováno v:
AAPS PharmSciTech. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ecbcbe1d93ff6273f38bd8dcff23e2
https://doi.org/10.1208/s12249-021-02165-w
https://doi.org/10.1208/s12249-021-02165-w