Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Stephen R Spindler"'
Autor:
Stephen R Spindler, Rui Li, Joseph M Dhahbi, Amy Yamakawa, Patricia Mote, Rolf Bodmer, Karen Ocorr, Renee T Williams, Yinsheng Wang, Kenneth P Ablao
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39581 (2012)
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals. Here we show that simvastatin significantly increased th
Externí odkaz:
https://doaj.org/article/d3ca8009de6843b5a3868d19b5cff627
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29782 (2012)
Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies. Herein we descri
Externí odkaz:
https://doaj.org/article/6337d47142b54161a8688e12e154aa06
Autor:
Joseph M Dhahbi, Hani Atamna, Dario Boffelli, Wendy Magis, Stephen R Spindler, David I K Martin
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20509 (2011)
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used dee
Externí odkaz:
https://doaj.org/article/b8f8b8f3e29540e89619990bf2e94abc
Autor:
Björn Schumacher, Ingrid van der Pluijm, Michael J Moorhouse, Theodore Kosteas, Andria Rasile Robinson, Yousin Suh, Timo M Breit, Harry van Steeg, Laura J Niedernhofer, Wilfred van Ijcken, Andrzej Bartke, Stephen R Spindler, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, George A Garinis
Publikováno v:
PLoS Genetics, Vol 4, Iss 8, p e1000161 (2008)
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity,
Externí odkaz:
https://doaj.org/article/eca5369f81bc4ad7bedd0952aee33ca6
Autor:
Joseph M. Dhahbi, James M. Flegal, Alex L. Lublin, Patricia L. Mote, Rui Li, Stephen R. Spindler
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Nordihydroguaiaretic Acid (NDGA) is a lignin which constitutes about 12.5% of the dry weight of the leaves and twigs of the creosote bush, Larrea tridentate [Reviewed in (1–4)]. Aqueous extracts of creosote leaves and twigs have been used medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee33282c45ffe8da72e999fdadcdd07
http://europepmc.org/articles/PMC4631105
http://europepmc.org/articles/PMC4631105
Publikováno v:
Communications in Statistics - Theory and Methods. 43:2689-2701
We develop a sample size methodology that achieves specified Type-1 and Type-2 error rates when comparing the survivor functions of multiple treatment groups versus a control group. The designs will control family-wise Type-1 error rate. We assume th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949885ea9f87f68cec2bf0246d48e93d
https://doi.org/10.1080/03610926.2012.683125
https://doi.org/10.1080/03610926.2012.683125
Autor:
Hani Atamna, David I. K. Martin, Dario Boffelli, Noel Guerrero, Stephen R. Spindler, Joseph M. Dhahbi, Amy Yamakawa, Patricia L. Mote
Publikováno v:
Aging (Albany NY)
MicroRNAs (miRNAs) function to modulate gene expression, and through this property they regulate a broad spectrum of cellular processes. They can circulate in blood and thereby mediate cell-to-cell communication. Aging involves changes in many cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c20eb3fc07fabf912fea5838f7e087
https://doi.org/10.18632/aging.100540
https://doi.org/10.18632/aging.100540
Autor:
Stephen R. Spindler, Patricia L. Mote, Rui Li, Joseph M. Dhahbi, Amy Yamakawa, James M. Flegal, Daniel R. Jeske, Alex L. Lublin
Publikováno v:
AGE. 35:2099-2109
Chronic treatment with β-adrenergic receptor (βAR) agonists increases mortality and morbidity while βAR antagonists (β-blockers) decrease all-cause mortality for those at risk of cardiac disease. Levels of sympathetic nervous system βAR agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee3a1011faf82206c84cb39d4ae5495
https://doi.org/10.1007/s11357-012-9498-3
https://doi.org/10.1007/s11357-012-9498-3
Publikováno v:
Physiological Genomics. 44:331-344
Sarcopenia is an age-associated loss of skeletal muscle mass and strength that increases the risk of disability. Calorie restriction (CR), the consumption of fewer calories while maintaining adequate nutrition, mitigates sarcopenia and many other age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aad8ab4d4ead713d527b4ecf5660da
https://doi.org/10.1152/physiolgenomics.00129.2011
https://doi.org/10.1152/physiolgenomics.00129.2011
Autor:
Stephen R. Spindler
Publikováno v:
Age
Much of the literature describing the search for agents that increase the life span of rodents was found to suffer from confounds. One-hundred-six studies, absent 20 contradictory melatonin studies, of compounds or combinations of compounds were revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e363abfed74292d990242b6994258d
https://doi.org/10.1007/s11357-011-9224-6
https://doi.org/10.1007/s11357-011-9224-6