Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Stephen R Morairty"'
The Hypocretin/Orexin Antagonist Almorexant Promotes Sleep Without Impairment of Performance in Rats
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM. HcrtR antagonists are hypothesized to induce sleep by disfacilitation of wake-promoti
Externí odkaz:
https://doaj.org/article/4dd5f7e22d864602baa55e34ae875237
Autor:
Stephen R Morairty, Florent G Revel, Pari Malherbe, Jean-Luc Moreau, Daniel Valladao, Joseph G Wettstein, Thomas S Kilduff, Edilio Borroni
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39131 (2012)
The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently unclear whether blockade of either or
Externí odkaz:
https://doaj.org/article/869b204300724eeea846840bc51ce84a
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Sleep/wake control involves several neurotransmitter and neuromodulatory systems yet the coordination of the behavioral and physiological processes underlying sleep is incompletely understood. Previous studies have suggested that activation of the No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c74d7954a8b270e3d5c3b0f06570188
https://doi.org/10.1073/pnas.2214171120
https://doi.org/10.1073/pnas.2214171120
Autor:
Yu Sun, Alok Ranjan, Ryan Tisdale, Shun‐Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R. Morairty, Xiaoyu Wang, Daniel M. Rosenbaum, Noelle S. Williams, Jef K. De Brabander, Thomas S. Kilduff
Publikováno v:
Journal of Sleep Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9a7503b0b4bf36cb1145b9f1dbd047
https://doi.org/10.1111/jsr.13839
https://doi.org/10.1111/jsr.13839
Autor:
Yu Sun, Alok Ranjan, Ryan Tisdale, Shun-Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R. Morairty, Xiaoyu Wang, Daniel M. Rosenbaum, Noelle S. Williams, Jef K. De Brabander, Thomas S. Kilduff
The sleep disorder Narcolepsy, a hypocretin deficiency disorder thought to be due to degeneration of hypothalamic hypocretin/orexin neurons, is currently treated symptomatically. We evaluated the efficacy of two small molecule hypocretin/orexin recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c515e44c161fd25461eb167fcdb30629
https://doi.org/10.1101/2022.12.09.519796
https://doi.org/10.1101/2022.12.09.519796
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Autor:
J. Heu, Thomas S. Kilduff, S. Park, Akihiro Yamanaka, Y. Sun, Stephen R. Morairty, S.-C. Ma, Ryan K Tisdale, G. Allocca, M. Haire
Publikováno v:
Sleep
Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created to model this disorder and are increasingly being used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3c80ad17d1f7a841b712a29e74e02
https://europepmc.org/articles/PMC9742901/
https://europepmc.org/articles/PMC9742901/
Autor:
Anushka V. Goonawardena, Thomas S. Kilduff, Gabriel A. Orellana, Ryan Dell, Marius C. Hoener, Stephen R. Morairty, Tanya L. Wallace
Publikováno v:
Neuropsychopharmacology
Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. TAAR1 agonists have pro-cognitive, antidepressant-, and antipsychotic-like properties in both rodents and non-human primates (NHPs). TAAR1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fe572c0920497845fee13551f9f41f
https://doi.org/10.1038/s41386-019-0386-8
https://doi.org/10.1038/s41386-019-0386-8
Autor:
Thomas S. Kilduff, Stephen R. Morairty, Anushka V. Goonawardena, Adrian R. Willoughby, Tanya L. Wallace, Gabriel A. Orellana
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 6, Iss, Pp 9-23 (2019)
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms
Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80557ff5407f6fe6eaa0caab2f645152
http://www.sciencedirect.com/science/article/pii/S2451994418300063
http://www.sciencedirect.com/science/article/pii/S2451994418300063
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279