Výsledky vyhledávání - "Stephen R Mattarollo"

Akademický článek

Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Autor: Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural

Externí odkaz: https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed

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Akademický článek

Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis.

Autor: Nor Malia Abd Warif, Patrizia Stoitzner, Graham R Leggatt, Stephen R Mattarollo, Ian H Frazer, Merilyn H Hibma

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127155 (2015)

It has previously been shown that expression of human papillomavirus type 16 (HPV) E7 in epidermis causes hyperplasia and chronic inflammation, characteristics of pre-malignant lesions. Importantly, E7-expressing epidermis is strongly immune suppress

Externí odkaz: https://doaj.org/article/497eae8c5deb4227ab151c595120b32d

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Akademický článek

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes.

Autor: Allison Choyce, Michelle Yong, Sharmal Narayan, Stephen R Mattarollo, Amy Liem, Paul F Lambert, Ian H Frazer, Graham R Leggatt

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57798 (2013)

Established cancers are frequently associated with a lymphocytic infiltrate that fails to clear the tumour mass. In contrast, the importance of recruited lymphocytes during premalignancy is less well understood. In a mouse model of premalignant skin

Externí odkaz: https://doaj.org/article/8eb0be7a565d48e49f0e3f56b494b3f4

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Data from NKT Cell–Driven Enhancement of Antitumor Immunity Induced by Clec9a-Targeted Tailorable Nanoemulsion

Autor: Stephen R. Mattarollo, Ranjeny Thomas, Graham Leggatt, Riccardo Dolcetti, Bijun Zeng, Megan Soon, Takumi Kobayashi, Pui Yeng Lam

Invariant natural killer T (iNKT) cells are a subset of lymphocytes with immune regulatory activity. Their ability to bridge the innate and adaptive immune systems has been studied using the glycolipid ligand α-galactosylceramide (αGC). To better h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e79093595c6398c9ca3098a315f12b
https://doi.org/10.1158/2326-6066.c.6549799.v1

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Data from An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

Autor: Ricky W. Johnstone, Mark J. Smyth, Ailsa J. Christiansen, Leonie A. Cluse, Jake Shortt, Stephen R. Mattarollo, Alison C. West

Cell-intrinsic effects such as induction of apoptosis and/or inhibition of cell proliferation have been proposed as the major antitumor responses to histone deacetylase inhibitors (HDACi). These compounds can also mediate immune-modulatory effects th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7069db089f67c1545c63b8e74b89e735
https://doi.org/10.1158/0008-5472.c.6504684

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