Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Stephen R Holdsworth"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190655 (2018)
The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signalling by comp
Externí odkaz:
https://doaj.org/article/7f8118ba60174c0798a555b84574ec79
Autor:
Joanna R Ghali, Kim M O'Sullivan, Peter J Eggenhuizen, Stephen R Holdsworth, A Richard Kitching
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123118 (2015)
Fms-like tyrosine kinase 3-ligand (FL) is a growth factor that may expand dendritic cell and regulatory T cell populations. We hypothesised that FL-induced regulatory T cells would protect mice from experimental rapidly progressive glomerulonephritis
Externí odkaz:
https://doaj.org/article/b82402d73a524bd3ba747305ffffd658
Autor:
Paul T King, Roleen Sharma, Kim O'Sullivan, Stavros Selemidis, Steven Lim, Naghmeh Radhakrishna, Camden Lo, Jyotika Prasad, Judy Callaghan, Peter McLaughlin, Michael Farmer, Daniel Steinfort, Barton Jennings, James Ngui, Bradley R S Broughton, Belinda Thomas, Ama-Tawiah Essilfie, Michael Hickey, Peter W Holmes, Philip Hansbro, Philip G Bardin, Stephen R Holdsworth
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120371 (2015)
Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NT
Externí odkaz:
https://doaj.org/article/2c10d59797b34610a811b91fc9d1f67b
Autor:
Sharon L. Ford, Kim M. O’Sullivan, A. Richard Kitching, Stephen R. Holdsworth, Poh Yi Gan, Shaun A. Summers
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1339 (2023)
ANCA-associated vasculitis (AAV) is intricately linked with infections. Toll-like receptors (TLR) provide a potential link between infection and anti-myeloperoxidase (MPO) autoimmunity. TLR9 ligation has been shown to promote anti-MPO autoimmunity an
Externí odkaz:
https://doaj.org/article/891f048a26584d48ac71a9dafef47d7e
Autor:
Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Ashleigh L. Fell, Rachel M. Y. Cheong, Wey Y. Wong, Poh-Yi Gan, Stephen R. Holdsworth, Joshua D. Ooi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epidemiological studies and clinical trials suggest Bacillus Calmette-Guérin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce
Externí odkaz:
https://doaj.org/article/4decf9b33a324a98b4d92aae9619899c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Anti-myeloperoxidase vasculitis (MPO-AAV) is a life-threatening autoimmune disease which causes severe inflammation of small blood vessels, mainly in the kidney. As for many other autoimmune diseases, current treatments, which consist of general immu
Externí odkaz:
https://doaj.org/article/5ebf5d0ec0fd4f54b4b90da62fb3cddf
Autor:
Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One potentiall
Externí odkaz:
https://doaj.org/article/117403dc98d74041be104999276d522c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Our understanding of immune recognition and response to infection and non-infectious forms of cell damage and death is rapidly increasing. The major focus is on host immunity and microbiological invasion. However, it is also clear that these same pat
Externí odkaz:
https://doaj.org/article/7b69170fd6e0428e85f2b9ff6f0885f1
Autor:
Amina Ahmad, Mawj Mandwie, Kim M. O'Sullivan, Christine Smyth, Jarrod York, Helen Doyle, Stephen R. Holdsworth, Matthew C. Pickering, Peter J. Lachmann, Ian E. Alexander, Grant J. Logan
Publikováno v:
Human Gene Therapy. 33:560-571
Adeno-associated virus (AAV) vectors are proving to be clinically transformative tools in the treatment of monogenic genetic disease. Rapid ongoing development of this technology promises to not only increase the number of monogenic disorders amenabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dadd56aaeb42d64dc86dfc050ab4cd
https://doi.org/10.1089/hum.2021.264
https://doi.org/10.1089/hum.2021.264
Autor:
Kim M. O’Sullivan, Virginie Oudin, Anne Cao Le, Jonathan Dick, Raymond Shim, Stephen R. Holdsworth, Daniel Koo Yuk Cheong, A. Richard Kitching, Joshua D. Ooi, Poh-Yi Gan, Maliha A. Alikhan
Publikováno v:
J Am Soc Nephrol
Background Myeloperoxidase ANCA-associated vasculitis is a major cause of ESKD. Efficacy of anti-CD20 mAb treatment was tested in a mouse model of the disease. Methods MPO immunization induced anti-MPO autoimmunity, and a subnephritogenic dose of she
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298f59e6df6398e995844df0b72e0560
https://doi.org/10.1681/asn.2020060834
https://doi.org/10.1681/asn.2020060834