Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Stephen R Hann"'
Autor:
Shanna K Nifoussi, Julie A Vrana, Aaron M Domina, Alfredo De Biasio, Jingang Gui, Mark A Gregory, Stephen R Hann, Ruth W Craig
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47060 (2012)
The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance
Externí odkaz:
https://doaj.org/article/44c4beca0b6b4370a1fa1cb8e3dadb1b
Autor:
Zhaoliang Li, Alex Panaccione, Kimberly West-Osterfield, Stephen R. Hann, Erick Spears, Qin Zhang
Publikováno v:
Genes; Volume 8; Issue 5; Pages: 134
Genes
Genes
MYC is a transcription factor that is essential for cellular proliferation and development. Deregulation or overexpression of MYC occurs in a variety of human cancers. Ectopic expression of MYC causes hyperproliferation and transformation of cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427d249bbf99453298ec8fd0b153a1d1
Autor:
Mouadh Benamar, Soumya Sasi, Michael L. Freeman, Konjeti R. Sekhar, Narsimha Reddy Penthala, Stephen R. Hann, Ramesh Balusu, Ling Geng, Peter A. Crooks, Amudhan Venkateswaran, Tarek Abbas
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 89:1106-1114
Purpose To test the hypothesis that small molecule targeting of nucleophosmin 1 (NPM1) represents a rational approach for radiosensitization. Methods and Materials Wilde-type and NPM1-deficient mouse embryo fibroblasts (MEFs) were used to determine w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619241e9456f41025b1554c7a5935e78
https://doi.org/10.1016/j.ijrobp.2014.04.012
https://doi.org/10.1016/j.ijrobp.2014.04.012
Publikováno v:
Proceedings of the National Academy of Sciences. 108:632-637
c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF and p53. Apoptosis induced by c-Myc is a critical fail-safe mechanism for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29674bebc28906b9e418950da0b63b70
https://doi.org/10.1073/pnas.1008848108
https://doi.org/10.1073/pnas.1008848108
Autor:
Stephen R. Hann, Zhaoliang Li
Publikováno v:
Cell Cycle. 8:2703-2707
The multifunctional nucleolar proteins, nucleophosmin (NPM) and the tumor suppressor ARF, have been assigned numerous roles in diverse cellular processes impacting cellular proliferation, tumorigenesis and apoptosis. In addition, both proteins have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4140e38c59aa562e33de4f020b1ac4b
https://doi.org/10.4161/cc.8.17.9418
https://doi.org/10.4161/cc.8.17.9418
Publikováno v:
Proceedings of the National Academy of Sciences. 105:18794-18799
The transcription factor c-Myc is essential for cellular proliferation and is one of the most frequently activated oncogenes, but the molecular mechanism mediating its critical role in transformation is unclear. Like c-Myc, multifunctional nucleophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab03aa620a87d0cd07a2542641e6d95f
https://doi.org/10.1073/pnas.0806879105
https://doi.org/10.1073/pnas.0806879105
Publikováno v:
Cell Cycle. 4:248-251
The ARF tumor suppressor protein acts in a checkpoint that guards against unscheduled cellular proliferation in response to oncogenic signaling. Deregulated expression of c-Myc induces ARF expression and apoptosis through the ARF-Mdm2-p53 axis. Our r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90fe0ea58940dcabf5d10704bfdf7aa2
https://doi.org/10.4161/cc.4.2.1491
https://doi.org/10.4161/cc.4.2.1491
Publikováno v:
Nature. 431:712-717
Increased expression of the oncogenic transcription factor c-Myc causes unregulated cell cycle progression1. c-Myc can also cause apoptosis, but it is not known whether the activation and/or repression of c-Myc target genes mediates these diverse fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b57aab16003daefe4fce439602187f
https://doi.org/10.1038/nature02958
https://doi.org/10.1038/nature02958
Publikováno v:
Methods in Molecular Biology ISBN: 9781493922680
Screens for small-molecule modulators of biological pathways typically utilize cultured cell lines, purified proteins, or, recently, model organisms (e.g., zebrafish, Drosophila, C. elegans). Herein, we describe a method for using Xenopus laevis egg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41187df98ba838d68964af982e22f252
https://doi.org/10.1007/978-1-4939-2269-7_5
https://doi.org/10.1007/978-1-4939-2269-7_5
Autor:
Stephen R. Hann
Publikováno v:
Cold Spring Harbor perspectives in medicine. 4(9)
The transcription factor MYC has fundamental roles in proliferation, apoptosis, tumorigenesis, and stem cell pluripotency. Over the last 30 years extensive information has been gathered on the numerous cofactors that interact with MYC and the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095dbce01ea42ccf2d345977a87c9d70
https://pubmed.ncbi.nlm.nih.gov/24939054
https://pubmed.ncbi.nlm.nih.gov/24939054