Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Stephen R Farmer"'
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197777 (2018)
White adipose tissue expands through both adipocyte hypertrophy and hyperplasia and it is hypothesized that fibrosis or excess accumulation of extracellular matrix within adipose tissue may limit tissue expansion contributing to metabolic dysfunction
Externí odkaz:
https://doaj.org/article/7a83fc4ac9c14b7a9b4af18f7aac64c2
Autor:
Mércia Beluzi, Sidney B Peres, Felipe S Henriques, Rogério A L Sertié, Felipe O Franco, Kaltinaitis B Santos, Pâmela Knobl, Sandra Andreotti, Cláudio S Shida, Rodrigo X Neves, Stephen R Farmer, Marília Seelaender, Fábio B Lima, Miguel L Batista
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122660 (2015)
Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal mu
Externí odkaz:
https://doaj.org/article/d3d701e0fd6842bdabf7d6a0d4bd7036
Autor:
Alexander J. Hu, Wei Li, Calvin Dinh, Yongzhao Zhang, Jamie K. Hu, Stefano G. Daniele, Xiaoli Hou, Zixuan Yang, John M. Asara, Guo-fu Hu, Stephen R. Farmer, Miaofen G. Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Increased de novo lipogenesis (DNL) in white adipose tissue is associated with insulin sensitivity. Under both Normal-Chow-Diet and High-Fat-Diet, mice expressing a kinase inactive Cyclin-dependent kinase 6 (Cdk6) allele (K43M) display an in
Externí odkaz:
https://doaj.org/article/5e069f55bdcc4eb388a07f8c066ec1cb
Autor:
Shakun Karki, Partha Chakrabarti, Guanrong Huang, Hong Wang, Stephen R Farmer, Konstantin V Kandror
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28146 (2011)
Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the elevated and/or dysregulated levels of circulating free fatty acids that cause and aggravat
Externí odkaz:
https://doaj.org/article/c8a77d3f774647e99c2b0f6099352d4a
Autor:
Alexander J. Hu, Wei Li, Apana Pathak, Guo-Fu Hu, Xiaoli Hou, Stephen R. Farmer, Miaofen G. Hu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Overweight or obesity poses a significant risk of many obesity-related metabolic diseases. Among all the potential new therapies, stem cell-based treatments hold great promise for treating many obesity-related metabolic diseases. However,
Externí odkaz:
https://doaj.org/article/4cc031b4ff2547fb80ff62b70a877ab8
Autor:
Saran Lotfollahzadeh, Chaoshuang Xia, Razie Amraei, Ning Hua, Konstantin V. Kandror, Stephen R. Farmer, Wenyi Wei, Catherine E. Costello, Vipul Chitalia, Nader Rahimi
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101744- (2023)
Objective: Obesity is a complex disorder and is linked to chronic diseases such as type 2 diabetes. Major intrinsically disordered NOTCH2-associated receptor2 (MINAR2) is an understudied protein with an unknown role in obesity and metabolism. The pur
Externí odkaz:
https://doaj.org/article/4ab846303ffe4f03a409db021e6fe8fc
Autor:
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight. Cyclin-de
Externí odkaz:
https://doaj.org/article/0c16856389d04c188e1aef084726356a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The vascular adventitia contains numerous cell types including fibroblasts, adipocytes, inflammatory cells, and progenitors embedded within a complex extracellular matrix (ECM) network. In response to vascular injury, adventitial progenitors
Externí odkaz:
https://doaj.org/article/7add016385324b19ad6457c3a169e374
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101765- (2020)
Summary: White adipose tissue (WAT) is a dynamic tissue, which responds to environmental stimuli and dietary cues by changing its morphology and metabolic capacity. The ability of WAT to undergo a beige remodeling has become an appealing strategy to
Externí odkaz:
https://doaj.org/article/c98a115f0377415b8b8645936aed1af6
Autor:
Yoseph W. Dance, Mackenzie C. Obenreder, Alex J. Seibel, Tova Meshulam, Joshua W. Ogony, Nikhil Lahiri, Laura Pacheco-Spann, Derek C. Radisky, Matthew D. Layne, Stephen R. Farmer, Celeste M. Nelson, Joe Tien
Publikováno v:
Cellular and Molecular Bioengineering. 16:23-39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf4c371f8b716a7a4d0c4db9b17d8337
https://doi.org/10.1007/s12195-022-00750-y
https://doi.org/10.1007/s12195-022-00750-y