Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stephen R Coats"'
Autor:
Connie Slocum, Stephen R Coats, Ning Hua, Carolyn Kramer, George Papadopoulos, Ellen O Weinberg, Cynthia V Gudino, James A Hamilton, Richard P Darveau, Caroline A Genco
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004215 (2014)
Several successful pathogens have evolved mechanisms to evade host defense, resulting in the establishment of persistent and chronic infections. One such pathogen, Porphyromonas gingivalis, induces chronic low-grade inflammation associated with local
Externí odkaz:
https://doaj.org/article/cac4e6ca31474606be3a0c5795c2b396
Autor:
George Papadopoulos, Richard P. Darveau, Robert Berland, Stephen R. Coats, Caroline A. Genco, Ashwini Sunkavalli
Publikováno v:
Infect Immun
The majority of Gram-negative bacteria elicit a potent immune response via recognition of lipid A expressed on the outer bacterial membrane by the host immune receptor Toll-like receptor 4 (TLR4). However, some Gram-negative bacteria evade detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160fa19d54474c4b99f2afaeb9aa5c6a
https://pubmed.ncbi.nlm.nih.gov/33257533
https://pubmed.ncbi.nlm.nih.gov/33257533
Autor:
Richard P. Darveau, Jeffrey S. McLean, Nutthapong Kantrong, Stephen R. Coats, Caroline A. Genco, Thao T. To, Sumita Jain
Publikováno v:
Infection and Immunity. 87
The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efee670789eb8efd29331791e5226550
https://doi.org/10.1128/iai.00319-19
https://doi.org/10.1128/iai.00319-19
Autor:
Manjot Singh, Jeffrey S. McLean, Ana M. Chang, Sumita Jain, Richard P. Darveau, Stephen R. Coats, Roger W. Kramer
Publikováno v:
Journal of Bacteriology. 201
Removal of one acyl chain from bacterial lipid A by deacylase activity is a mechanism used by many pathogenic bacteria to evade the host's Toll-like receptor 4 (TLR4)-mediated innate immune response. In Porphyromonas gingivalis, a periodontal pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb7b3cf6a986b80edf8db86c59715a1
https://doi.org/10.1128/jb.00683-18
https://doi.org/10.1128/jb.00683-18
Autor:
Stephen R, Coats, Nutthapong, Kantrong, Thao T, To, Sumita, Jain, Caroline A, Genco, Jeffrey S, McLean, Richard P, Darveau
Publikováno v:
Infect Immun
The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7e9cbd7f6d0ba31a896d19fbd7759e9
https://pubmed.ncbi.nlm.nih.gov/31570556
https://pubmed.ncbi.nlm.nih.gov/31570556
Publikováno v:
Infection and Immunity. 81:1277-1286
Infection by the chronic periodontitis-associated pathogen Porphyromonas gingivalis activates a Toll-like receptor 2 (TLR2) response that triggers inflammation in the host but also promotes bacterial persistence. Our aim was to define ligands on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0279f3f134a0009b69d5d0bdb4a9faf3
https://doi.org/10.1128/iai.01036-12
https://doi.org/10.1128/iai.01036-12
Autor:
Ahmed Hashim, Thao T. To, Stephen R. Coats, Richard P. Darveau, Michael A. Curtis, Nikolay Paramonov
Intestinal homeostasis mechanisms must protect the host intestinal tissue from endogenous lipopolysaccharides (LPSs) produced by the intestinal microbiota. In this report, we demonstrate that murine intestinal fecal lipids effectively block Toll-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9834e9040139be3d70ef89451e7760b6
https://europepmc.org/articles/PMC4959216/
https://europepmc.org/articles/PMC4959216/
Autor:
Michael A. Curtis, Edward Tarelli, Deirdre A. Devine, Minnie Rangarajan, R.S. Percival, Richard P. Darveau, Stephen R. Coats, Philip Marsh
Publikováno v:
Infection and Immunity. 79:1187-1193
Lipid A structure is a critical determinant of the interaction between pathogens and the innate immune system. Previously, we demonstrated the presence of non- and monophosphorylated tetra-acylated lipid A structures in the outer membrane of Porphyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbb2f1eea621a5fc75f79b684b23f24
https://doi.org/10.1128/iai.00900-10
https://doi.org/10.1128/iai.00900-10
Autor:
Karim P. Banani, Thao T. To, Richard P. Darveau, Sumita Jain, Alex B. Berezow, Brian W. Bainbridge, Stephen R. Coats
Publikováno v:
Infection and Immunity. 79:203-210
The human symbiont Bacteroides thetaiotaomicron promotes intestinal function and health, whereas the phylogenetically related pathogen Porphyromonas gingivalis is associated with the chronic oral inflammatory disease periodontitis. Although both B. t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356b71bb2ec8e402cbdb01a5f933fa00
https://doi.org/10.1128/iai.00937-10
https://doi.org/10.1128/iai.00937-10
Publikováno v:
International Journal of Oral Science
Aim To elucidate the genetic basis for the pronounced resistance that the oral pathogen, Porphyromonas gingivalis (P. gingivalis), exhibits towards the cationic antimicrobial peptide, polymyxin B. Methodology A genetic screen of P. gingivalis clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632cfe815927f1142fe8ffd7e641dbbc
https://doi.org/10.4248/ijos.09062
https://doi.org/10.4248/ijos.09062