Výsledky vyhledávání - "Stephen Philip Jackson"

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination

Autor: Felipe Cortés Ledesma, Yukihide Tomari, Stephen Philip Jackson, Pablo Huertas, Sandra Muñoz-Galván, Ana López Saavedra, Andres Aguilera

Publikováno v: Nucleic Acids Research
Nucleic Acids Research; Vol 41
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC

While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of double-strand break (DSB) repair is exerted at several steps, the key step is DNA end resection, which in Saccharomyces cerevisiae is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753292d9e5578f3367b344fd5fa8c3a

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Competitive and noncompetitive inhibition of the DNA-dependent protein kinase

Autor: Ra, Izzard, Stephen Philip Jackson, Gc, Smith

Publikováno v: Europe PubMed Central

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase that is involved in mammalian DNA double-strand break repair. The catalytic subunit of DNA-PK (DNA-PKcs) shares sequence homology in its kinase domain with phosphatidylino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0d8da705d0dd4e2de68c347b877bca82
https://pubmed.ncbi.nlm.nih.gov/10363977

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DNA-dependent protein kinase and related proteins

Autor: Gc, Smith, Divecha N, Nd, Lakin, Stephen Philip Jackson

Publikováno v: Europe PubMed Central

The DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that must bind to DNA double-strand breaks to be active. We and others have shown that it is a multiprotein complex comprising an approx. 465 kDa catalytic subunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b22f96076f6c87332cf30071987f5f52
https://pubmed.ncbi.nlm.nih.gov/10207623

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Analysis of the ATM protein in wild-type and ataxia telangiectasia cells

Autor: Nd, Lakin, Weber P, Stankovic T, St, Rottinghaus, Am, Taylor, Stephen Philip Jackson

Publikováno v: Europe PubMed Central

Ataxia telangiectasia (A-T) is a human disorder that results in a number of clinical symptoms, including cerebellar degeneration and increased cancer predisposition. Recently the gene that is defective in A-T has been cloned and designated ATM. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::61e41252820823cc2615ae24d39c720a
https://pubmed.ncbi.nlm.nih.gov/9000145

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DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis

Autor: Song Q, Sp, Lees-Miller, Kumar S, Zhang Z, Dw, Chan, Gc, Smith, Stephen Philip Jackson, Es, Alnemri, Litwack G, Kk, Khanna, Mf, Lavin

Publikováno v: Europe PubMed Central

Radiosensitive cell lines derived from X-ray cross complementing group 5 (XRCC5), SCID mice and a human glioma cell line lack components of the DNA-dependent protein kinase, DNA-PK, suggesting that DNA-PK plays an important role in DNA double-strand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::afd395f39ae75d2b3c6b21eb6cb9c394
http://europepmc.org/abstract/med/8670824

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Identification of the catalytic subunit of DNA dependent protein kinase as the product of the mouse scid gene

Autor: Pa, Jeggo, Stephen Philip Jackson, Ge, Taccioli

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b00b07bc6f92a9bdb77c5b69a9627b8
http://europepmc.org/abstract/med/8787619

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Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage

Autor: Ac, Lee, Fernandez-Capetillo O, Pisupati V, Stephen Philip Jackson, Nussenzweig A

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ad3da210ea61c84f03385e5bce2b472
http://europepmc.org/abstract/med/15611643

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The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation

Autor: Jongmans W, Artuso M, Vuillaume M, Brésil H, Stephen Philip Jackson, Hall J

Publikováno v: Europe PubMed Central

The DNA-dependent protein kinase (DNA-PK), whose catalytic subunit shows structural similarities to the Ataxia telangiectasia (AT) gene product (ATM), has also been implicated in the p53-mediated signal transduction pathway that activates the cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eba6ca73b3fe94a1289b8d7597dc45df
http://europepmc.org/abstract/med/8808686

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Akademický článek

2016 King Faisal International Prize for Science and Medicine.

Autor: Khan, Sameen Ahmed¹ rohelakhan@yahoo.com

Publikováno v: Current Science (00113891). 4/10/2016, Vol. 110 Issue 7, p1140-1141. 2p.

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Elektronická kniha

Evaluation of the Markey Scholars Program

Autor: National Research Council, Policy and Global Affairs, Board on Higher Education and Workforce, Committee for the Evaluation of the Lucille P. Markey Charitable Trust Programs in Biomedical Sciences

One of five in a series evaluating the grant programs of the Lucille P. Markey Charitable Trust, this report examines the Markey Scholars Awards in Biomedical Sciences. The Scholars program awarded more than $50 million to outstanding young investiga

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