Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephen Paul Wren"'
Autor:
Carole Eliane Andree Maillol, Richard Storer, Severine Danielle Poignant, Peter David Johnson, Renate van Well, Stephen Paul Wren, Jonathon M. Tinsley, Adam G. Lambert, Gary Nugent, Francis Xavier Wilson, Fraser J. Wilkes, Colin Richard Dorgan, Richard Vickers, Graham Michael Wynne, Cristina Lecci, Richard Joseph Pye, Olivier De Moor, Paul Damien Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4828-4831
Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with att
Autor:
Severine Danielle Poignant, Fraser J. Wilkes, Kay E. Davies, Adam G. Lambert, J Vile, P J Middleton, Francis Xavier Wilson, Peter David Johnson, Stephen Paul Wren, Carole Eliane Andree Maillol, Richard Storer, Chancellor, D Lawrence, Collin Richard Dorgan, Richard Vickers, Graham Michael Wynne, A Potter, Cristina Lecci, Paul Damien Price, Gary Nugent, O De Moor, Richard Joseph Pye, R van Well, Jonathon M. Tinsley
Publikováno v:
Journal of Medicinal Chemistry. 54:3241-3250
A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential t
Autor:
Alan Geoffrey Roach, Dennis Norman, Melanie Wong, Hazel Joan Dyke, Sue Cramp, Stephen Paul Wren, Rosa Arienzo, Peter Lockey, Phil Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1403-1407
We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro
Autor:
Keith A. J. Stuttle, Peter Lockey, Dennis Norman, Melanie Wong, David E. Clark, Alan Geoffrey Roach, Hazel Joan Dyke, Stephen Daly, Stephen Paul Wren, Sue Cramp, Rosa Arienzo, Maxine Tomlinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4099-4102
A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the
Autor:
Neil Harris, Arne Mørk, Garrick Paul Smith, Guillaume Brandt, Stephen Paul Wren, Claus Tornby Christoffersen, Thomas Ruhland, Kim Andersen, Lene Hjorth Alifrangis, Gitte Mikkelsen, Barry M. Wyman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4027-4030
Elevation of glycine levels and activation of the NMDA receptor by inhibition of the glycine transporter 1 (GlyT-1) is a potential strategy for the treatment of schizophrenia. A novel series of GlyT-1 inhibitors have been identified containing the 2-
Autor:
Warren Miller, Simon Cocks, Deanne Thompson, Sukhjit Sohal, Prakash Mistry, John Milton, Richard Faint, Stephen Paul Wren, John W. Scott, Irina Chuckowree, Shouming Wang, Lyndsay Smith, Xiao-Ling Fan Cockcroft, Paul Depledge, Hazel Jones, Nigel Vicker, Adrian Folkes
Publikováno v:
Journal of Medicinal Chemistry. 47:1329-1338
Multidrug resistance mediated by P-glycoprotein (Pgp) or multidrug-resistance-associated protein (MRP) remains a major obstacle for successful treatment of cancer. Inhibition of Pgp and MRP transport is important for high efficacy of anticancer drugs
Autor:
Irina S. Chuckowree, Adrian Folkes, Rory Dodd, Stephen Paul Wren, and Alistair J. Stewart, Warren Miller, Luke Burgess, Sukhjit Sohal, David J. Hardick, Prakash Mistry, Timothy C. Hancox, Nigel Vicker, Chris Liddle, Shouming Wang, William A. Denny, Wendy Dangerfield, Peter Charlton, John Milton
Publikováno v:
Journal of Medicinal Chemistry. 45:721-739
A series of substituted angular benzophenazines were prepared using a new synthetic route via a novel regiocontrolled condensation of 1,2-naphthoquinones and 2,3-diaminobenzoic acids. The synthesis and biological activity of this new series of substi
Autor:
Sarah E. Squire, Fraser J. Wilkes, R.J. Fairclough, D Powell, Richard Storer, Adam G. Lambert, Anna Cozzoli, A Potter, Roberta Francesca Capogrosso, Stephen Paul Wren, Francis Xavier Wilson, Jonathon M. Tinsley, Annamaria De Luca, Kay E. Davies
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e19189 (2011)
PLoS ONE, Vol 6, Iss 5, p e19189 (2011)
BACKGROUND: Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fibers leading to the gradual depletion of skeletal muscle. There
Autor:
Hazel Joan Dyke, Peter Lockey, Melanie Wong, Stephen Paul Wren, Christopher Higgs, David E. Clark, Alan Geoffrey Roach, Dennis Norman
Publikováno v:
Journal of medicinal chemistry. 47(16)
Melanin-concentrating hormone (MCH) has been known to be an appetite-stimulating peptide for a number of years. However, it is only recently that MCH has been discovered to be the natural ligand for a previously "orphan" G-protein-coupled receptor, n
Autor:
Peter Charlton, John Spencer, Golec Julian M C, Shouming Wang, Stephen Paul Wren, Teresa Brooks, Kevin Hardman, Susannah Williams, Warren Miller, Adrian Folkes, Sandra Milutinovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(17)
Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition. Moderate to good activity was retained with the elimination of unattractive characteristics i