Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Stephen Patterson"'
Autor:
Richard J. Wall, Stuart A. MacGowan, Irene Hallyburton, Aisha J. Syed, Sowmya Ajay Castro, Gourav Dey, Rachel Milne, Stephen Patterson, Jody Phelan, Natalie Wiedemar, Susan Wyllie
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT New and improved drugs are required for the treatment and ultimate eradication of malaria. The efficacy of front-line therapies is now threatened by emerging drug resistance; thus, new tools to support the development of drugs with a lower p
Externí odkaz:
https://doaj.org/article/33debac63a434d15a1b26f35732aa229
Autor:
Robert J. Smith, Rachel Milne, Victoriano Corpas Lopez, Natalie Wiedemar, Gourav Dey, Aisha J. Syed, Stephen Patterson, Susan Wyllie
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102002- (2023)
Summary: Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor selectively binds its molec
Externí odkaz:
https://doaj.org/article/1a30dcc35b09405bb943795be1123f19
Autor:
Joshua P. Bobko, Mrinal Sinha, David Chen, Stephen Patterson, Todd Baldridge, Michael Eby, William Harris, Ryan Starling, Ofer Lichtman
Publikováno v:
Western Journal of Emergency Medicine, Vol 19, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/c7ed539969494c4ebf500c22716b746b
Autor:
Susan Wyllie, Adam J Roberts, Suzanne Norval, Stephen Patterson, Bernardo J Foth, Matthew Berriman, Kevin D Read, Alan H Fairlamb
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005971 (2016)
Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treat
Externí odkaz:
https://doaj.org/article/a48909d39e464a929a528cc874527d3f
Autor:
Stephen Patterson, Susan Wyllie, Suzanne Norval, Laste Stojanovski, Frederick RC Simeons, Jennifer L Auer, Maria Osuna-Cabello, Kevin D Read, Alan H Fairlamb
Publikováno v:
eLife, Vol 5 (2016)
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania
Externí odkaz:
https://doaj.org/article/830d1f9ce1e54963993ed6b35157f836
Autor:
Deuan C Jones, Bernardo J Foth, Michael D Urbaniak, Stephen Patterson, Han B Ong, Matthew Berriman, Alan H Fairlamb
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004299 (2015)
SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILA
Externí odkaz:
https://doaj.org/article/74159255136f410d997c5011131409c9
Autor:
Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J. Wall, Alice Dawson, David A. Robinson, Sharon M. Shepherd, Robert J. Smith, Irene Hallyburton, John M. Post, Karen Dowers, Leah S. Torrie, Ian H. Gilbert, Beatriz Baragaña, Stephen Patterson, Susan Wyllie
Publikováno v:
ACS Infectious Diseases. 8:1962-1974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ffb3cb31c0aa59ce11128553ce7e12
https://doi.org/10.1021/acsinfecdis.2c00364
https://doi.org/10.1021/acsinfecdis.2c00364
Autor:
Russell Brewer, Bryce Westlake, Thomas Swearingen, Stephen Patterson, David Bright, Arun Ross, Katie Logos, Dana Michalski
This paper demonstrates how biometric features can be extracted from people in child sexual abuse material (CSAM) and examined using social network analysis to reveal important patterns across seized media files. Using an automated software system pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85515203dcfad2a1508d55be9455d53d
https://doi.org/10.52922/ti78948
https://doi.org/10.52922/ti78948
Publikováno v:
Journal of Elite Sport Performance.
Background and aim: The study compared differences in derived critical velocity (CV) and maximal speed from the 3-Minute All-Out Shuttle Test (3MST), 7-Minute Intermittent Critical Velocity Shuttle Test (7MST) and 3-Minute All-Out Running Test (3MRT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::672032cee40d6f4e62d6a84429007005
https://doi.org/10.54080/qkbn5713
https://doi.org/10.54080/qkbn5713
Autor:
Stephen Patterson
Publikováno v:
Courtly Gifts and Cultural Diplomacy ISBN: 9783506793768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb2f33dd2a2830b3c965d5cf139976b
https://doi.org/10.30965/9783657793761_013
https://doi.org/10.30965/9783657793761_013