Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephen Pacchione"'
Autor:
Stephen Pacchione, Amy B. Barnum, Jayanthi J. Wolf, Philip J. Troilo, Thomas G. Griffiths, Cindy Pauley, B J Ledwith, Laural B. Harper, Zhibin Wang, José A. Lebrón
Publikováno v:
Gene Therapy. 29:322-332
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Autor:
José A. Lebrón, Kaushik Mitra, Keith Q. Tanis, Thomas G. Griffiths, Stephen Pacchione, Matthew Kuhls, Ian Knemeyer, Donald J Marsh, Wen Kang, Frank D. Sistare, Zhibin Wang, Qing Chen, Kimberly B. Bleicher, Ming Su, George M. Laws, Alexei A. Podtelezhnikov
Publikováno v:
Toxicological Sciences. 177:121-139
Early risk assessment of drug-induced liver injury (DILI) potential for drug candidates remains a major challenge for pharmaceutical development. We have previously developed a set of rat liver transcriptional biomarkers in short-term toxicity studie
Autor:
Todd Pippert, Amy G Aslamkhan, Keith Q. Tanis, Stephen Pacchione, Chunhua Qin, Warren E. Glaab, Alexei A. Podtelezhnikov, Frank D. Sistare, Kara Pearson, Erika Frank
Publikováno v:
Toxicological Sciences. 171:46-55
Aryl hydrocarbon receptor (AhR) activation is associated with carcinogenicity of non-genotoxic AhR-activating carcinogens such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), and is often observed with drug candidate molecules in development and raises s
Autor:
Amy Loughlin, Lisa LaFranco-Scheuch, Heather Vu, Tara Grady Styring, Nianyu Li, Stephen Pacchione, Warren E. Glaab, Alan S. Bass, Nicolas Solban, J. Richard Miller, Ivy Garfinkel, Heather Zhou, Bhavana Bhatt, Amy G. Aslamkhan, Qiuwei Xu, Kara Pearson, Spencer Reynolds
Publikováno v:
Toxicology and applied pharmacology. 406
Indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase 2 (TDO2) degrade tryptophan (Trp) to kynurenine (Kyn), and these enzymes have promise as therapeutic targets. A comprehensive characterization of potential safety liabilities of IDO1
Autor:
José A. Lebrón, Donna Lynch, Kristin Geddes, Stephen Pacchione, Hong Duong, Yutai Li, Warren E. Glaab, Alema Galijatovic-Idrizbegovic, Frank D. Sistare, Wen Kang, Raymond J. Gonzalez, Daniel J. Holder, Kyeongmi Cheon, Kara Pearson, Nanyan Rena Zhang, Alex M Tamburino, Michael J. Hafey, Raymond Evers, Keith Q. Tanis, Lisa LaFranco-Scheuch
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 170(1)
Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep th
Autor:
José A. Lebrón, Frank D. Sistare, Qing Chen, Donald J Marsh, Matthew Kuhls, Timothy E. Johnson, Wen Kang, Zhibin Wang, George Laws, Kaushik Mitra, James J. Monroe, Keith Q. Tanis, Thomas G. Griffiths, Kimberly B. Bleicher, Ming Su, Alexei A. Podtelezhnikov, Stephen Pacchione, Ian Knemeyer
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S42
Autor:
Randy R. Miller, Todd Pippert, Timothy E. Johnson, Deborah Nicoll-Griffith, Amy G. Aslamkhan, Frank D. Sistare, Wendy J. Bailey, Sam Machotka Palamanda, Stephen Pacchione, Kaushik Mitra, Tamara D. Cabalu, Raymond Evers, Pierre Daublain, Keith Q. Tanis, Kathleen Cox, Truyen Nguyen, Warren E. Glaab, Nancy G. B. Agrawal, Alexei A. Podtelezhnikov, Donna Lynch, James J Monroe
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S36
Autor:
Zhutian Niu, Thomas G. Griffiths, Krista L. Striano, Zhibin Wang, Stephen Pacchione, José A. Lebrón, Jayanthi J. Wolf, Philip J. Troilo
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:174-179
Introduction Various animal models are routinely used to evaluate the efficacy and toxicity of small interfering RNA (siRNA) therapeutics. Given that the most common measure of efficacy with siRNA therapeutics is mRNA knockdown, the development of a
Autor:
Kathleen A. McNulty, John E. Barnum, Stephen Pacchione, Jin Shang, Chunhua Qin, Kavitha Bekkari, Rong Liu, Alan Ng, Richard D. Storer, Zhibin Wang
Publikováno v:
Molecular Carcinogenesis. 49:54-67
Rodents, mice and rats in particular, are the species of choice for evaluating chemical carcinogenesis. However, different species and strains often respond very differently, undermining the logic of extrapolation of animal results to humans and comp
Autor:
Izhack Hemo, Eithan Galun, Zhutian Niu, Gideon Zamir, Orit Papo, Ofer Nussbaum, Dana F. Roden, Philip J. Troilo, Zakharia Manevitch, Michal Gropp, Evelyne Zeira, Rimma Barsuk, Nili Daudi, Stephen Pacchione, Alexandra Manevitch, Thomas G. Griffiths, Aaron Lewis, Hagit Yotvat, Menahem Harati, Eli Kedar
Publikováno v:
The FASEB Journal. 21:3522-3533
A femtosecond laser beam gene transduction (SG-LBGT) system is described as a novel and efficient method of intradermal (i.d.) nonviral gene delivery in mice by permeabilizing cells utilizing femtosecond laser pulses. Using this approach, significant