Výsledky vyhledávání - "Stephen P. Squinto"

Laboratory Studies in Cross-Species Lung Transplantation

Autor: J. H. Burack, Stephen P. Squinto, M Vaynblatt, Lawson N, S L Kamholz, M. J. Del Rio, Allen J. Norin, Grijalva Ga, W L Fodor, R. J. Brewer

Publikováno v: World Journal of Surgery. 21:951-955

The lack of sufficient suitable human donor lungs for the many patients requiring pulmonary transplantation as life-saving therapy for end-stage lung diseases has generated extensive interest in cross-species lung transplantation. Ethical concerns an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afce2611b971ae72dddb82462afca21
https://doi.org/10.1007/s002689900332

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EXPRESSION OF HUMAN CD59 IN TRANSGENIC PIG ORGANS ENHANCES ORGAN SURVIVAL IN AN EX VIVO XENOGENEIC PERFUSION MODEL1,2

Autor: E R Guilmette, Bolman Rm rd, Agustin P. Dalmasso, Barry L. Williams, Stephen P. Squinto, Scott A. Rollins, William L. Fodor, Kroshus Tj

Publikováno v: Transplantation. 61:1513-1521

The serious shortage of available donor organs for patients with end stage organ failure who are in need of solid organ transplantation has led to a heightened interest in xenotransplantation. The major barrier to successful discordant xenotransplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72d9697c7dc5cd8fa5a288a7a9146809
https://doi.org/10.1097/00007890-199605270-00018

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Reduction of the major porcine xenoantigen Galoc(1,3)Gal by expression of α(1,2)fucosyltransferase

Autor: S. Cohney, Effie Mouhtouris, William L. Fodor, Stephen P. Squinto, Scott A. Rollins, Narin Osman, Mauro S. Sandrin, Ian F. C. McKenzie

Publikováno v: Xenotransplantation. 3:134-140

Although removal of the Galα(1,3)Gal antigen from pigs would prevent hyperacute graft rejection, the technique of homologous recombination to knock out the α 1,3 galactosyltransferase gene is not available for pigs, and an alternative strategy is p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b768ea486cea87945f9a74bbb1cb7883
https://doi.org/10.1111/j.1399-3089.1996.tb00130.x

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Injectable retroviral particles for human gene therapy

Autor: Stephen P. Squinto, Russell P. Rother, Jeremy P. Springhorn, Scott A. Rollins, William L. Fodor

Publikováno v: Advanced Drug Delivery Reviews. 17:213-226

The use of retroviral-mediated gene transfer as an in vivo approach for the treatment of human disease has been limited by the inability of retroviral vectors to survive the host humoral immune system. The rapid inactivation of retroviruses that ensu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf257ba78f94e2f4546852ff29bae639
https://doi.org/10.1016/0169-409x(95)00054-b

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COMPLEMENT INHIBITION WITH AN ANTI-C5 MONOCLONAL ANTIBODY PREVENTS ACUTE CARDIAC TISSUE INJURY IN AN EX VIVO MODEL OF PIG-TO-HUMAN XENOTRANSPLANTATION

Autor: Eileen A. Elliott, Bolman Rm rd, Kroshus Tj, Stephen P. Squinto, Louis A. Matis, Agustin P. Dalmasso, Scott A. Rollins

Publikováno v: Transplantation. 60:1194-1201

Prevention of hyperacute xenograft rejection in the pig-to-primate combination has been accomplished by removal of natural antibodies, complement depletion with cobra venom factor, or prevention of C3 activation with the soluble complement inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76efe87964cf8615b1c6fcc10a5b95e8
https://doi.org/10.1097/00007890-199512000-00003

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In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5

Autor: Mark J. Evans, John P. Mueller, Steven H. Nye, Russell P. Rother, Stephen P. Squinto, Allen J. Norin, James A. Wilkins, Galo A Grijalva, Dennis W. Wolff, Denise M Therrien, Scott A. Rollins

Publikováno v: Molecular Immunology. 32:1183-1195

Complement activation has been implicated in the pathogenesis of several human diseases. Recently, a monoclonal antibody, (N19-8) that recognizes the human complement protein C5 has been shown to effectively block the cleavage of C5 into C5a and C5b,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8880708a39db086a0ba15f383dfe39c9
https://doi.org/10.1016/0161-5890(95)00099-2

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Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation

Autor: Henry M. Rinder, Scott A. Rollins, M. Smith, Stephen P. Squinto, Brian R. Smith, Christine S. Rinder, Louis A. Matis, Jayne B. Tracey, Jane C. K. Fitch

Publikováno v: Journal of Clinical Investigation. 96:1564-1572

Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass activates leukocytes and platelets; however the contribution of early (3a) versus late (C5a, solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8593eb33c7cba02c258df1179ea0c22
https://doi.org/10.1172/jci118195

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Rapid expression of an anti-human C5 chimeric Fab utilizing a vector that replicates in COS and 293 cells

Autor: Stephen P. Squinto, Mark J. Evans, Dennis W. Wolff, Scott A. Rollins, Sandra L. Hartman

Publikováno v: Journal of Immunological Methods. 184:123-138

Inhibition of complement system activation requires the development of soluble nonimmunogenic inhibitors with good tissue penetrating abilities that are themselves unable to activate complement. Chimeric mouse/human Fabs capable of blocking the activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818fc17bae28dfea628a7edc1d58ab22
https://doi.org/10.1016/0022-1759(95)00093-p

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Human capillary endothelial cells from abdominal wall adipose tissue: Isolation using an anti-pecam antibody

Autor: Stephen P. Squinto, Joseph A. Madri, Jeremy P. Springhorn

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 31:473-481

We have developed a novel isolation technique for harvesting human capillary endothelial cells. We compared the use of either Ulex Europaeus Agglutinin (UEA) lectin or anti-platelet endothelial cell adhesion molecule (PECAM) antibody conjugated to ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac81c6148bf0652a24e0648d3995ed99
https://doi.org/10.1007/bf02634261

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