Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Stephen P. Loughran"'
Autor:
Eoghan J. Mulholland, Monika Ziminska, Tracy Robson, Grace Cole, Vicky L. Kett, Helen O. McCarthy, Emma M. McErlean, Nicholas Dunne, Cian M. McCrudden, Niamh E. Buckley, John W. McBride, Stephen P. Loughran
Publikováno v:
McErlean, E M, Ziminska, M, McCrudden, C M, McBride, J W, Loughran, S P, Cole, G, Mulholland, E J, Kett, V, Buckley, N E, Robson, T, Dunne, N J & McCarthy, H O 2020, ' Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery ', Journal of Controlled Release, vol. 330, pp. 1288 . https://doi.org/10.1016/j.jconrel.2020.11.037
The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also challenging proposition. The ideal gene delivery vector must be non-toxic, non-immunogenic, overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f03a6e561e7b2be5887b475b411cf9e
https://doi.org/10.1016/j.jconrel.2020.11.037
https://doi.org/10.1016/j.jconrel.2020.11.037
Autor:
Nicholas Dunne, Grace Cole, Helen O. McCarthy, Aleksey Zholobenko, Tracy Robson, Victoria Kett, Joanne McCaffrey, Ahlam A. Ali, Kun-Hung Chen, John W. McBride, Cian M. McCrudden, Stephen P. Loughran, Ashley S. Massey, Ryan F. Donnelly, Sreekanth Pentlavalli
Publikováno v:
Journal of Controlled Release. 189:141-149
The design of a non-viral gene delivery vehicle capable of delivering and releasing a functional nucleic acid cargo intracellularly remains a formidable challenge. For systemic gene therapy to be successful a delivery vehicle is required that protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add243508423bf6f447f9e632e5f4818
https://doi.org/10.1016/j.jconrel.2014.06.048
https://doi.org/10.1016/j.jconrel.2014.06.048
Publikováno v:
Loughran, S P, McCrudden, C M & McCarthy, H O 2015, ' Designer peptide delivery systems for gene therapy ', European Journal of Nanomedicine, vol. 7, no. 2, pp. 85-96 . https://doi.org/10.1515/ejnm-2014-0037
Gene therapy has long been hailed as a revolutionary approach for the treatment of genetic diseases. The enthusiasm that greeted the harnessing of viruses for therapeutic DNA delivery has been tempered by concerns over safety. These concerns led to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c07365132f9ee6c21d52b695fade3
https://doi.org/10.1515/ejnm-2014-0037
https://doi.org/10.1515/ejnm-2014-0037