Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephen P. Keen"'
Autor:
Ji Qi, Yu-hong Lam, Adrian Goodyear, Jie Wang, Ed Cleator, Mahbub Alam, Mariko Morimoto, Andy Kirtley, Andrew D. Gibb, Steven F. Oliver, Stephen P. Keen, Matthew L. Maddess, Lingzhu Kong, Alejandro Dieguez-Vazquez, Xin Wen
Publikováno v:
Organic Process Research & Development. 26:640-647
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfbad35e1d76c484460c5e3a274e6e5
https://doi.org/10.1021/acs.oprd.1c00098
https://doi.org/10.1021/acs.oprd.1c00098
Autor:
Robert A. Reamer, Jeffrey C. Moore, Stephen P. Keen, Lin Wang, Feng Peng, Billy Chen, Andrew W. Gibson, David R. Lieberman, David Murray, Kevin M. Belyk, Erika M. Milczek, Michael Williams, Ji Qi, Jongrock Kong, Lushi Tan, Mark McLaughlin, Zhiguo J. Song
Publikováno v:
Organic Letters. 19:926-929
An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features of stereocontrol include construction of the fully substituted 4'-carbon via a biocatalytic desymmetrization of 2-hydroxy-2-((triisopropylsilyl)ethynyl)pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e08712d40da238e75392804655ffca0
https://doi.org/10.1021/acs.orglett.7b00091
https://doi.org/10.1021/acs.orglett.7b00091
Autor:
Varsolona Richard J, Jeremy P. Scott, Andrew W. Gibson, Lorenzo Codan, Xianliang He, Sophie Strickfuss, Lushi Tan, Alfred Y. Lee, Feng Wen, Wei Lin, Mark McLaughlin, Stephen P. Keen, Qinghao Chen, David R. Lieberman, Guiquan Liu, Mikhail Reibarkh, Spencer D. Dreher, Yan Jin, Michael Williams, Renee K. Dermenjian
Publikováno v:
Organic Process Research & Development. 20:1227-1238
We describe the route development and multikilogram-scale synthesis of an HCV NS5B site D inhibitor, MK-8876. The key topics covered are (1) process improvement of the two main fragments; (2) optimization of the initially troublesome penultimate step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa863929f3ac296401789ae4c0011ea
https://doi.org/10.1021/acs.oprd.5b00405
https://doi.org/10.1021/acs.oprd.5b00405
Autor:
Melissa E. Howard, Andrew W. Gibson, Alejandro Dieguez-Vazquez, Debra J. Wallace, Artis Klapars, Robert D. Wilson, Jeremy P. Scott, Peter R. Mullens, Andrew D. Gibb, Carl A. Baxter, Jaemoon Lee, Sarah E. Brewer, Stephen P. Keen, Ed Cleator, Nadine Bremeyer, Anthony Alorati, Kevin R. Campos, Matthew L. Maddess, Joseph J. Lynch, Jing Li
Publikováno v:
Organic Process Research & Development. 18:528-538
The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10,11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdefbcc65171430752e7a0100c3ac289
https://doi.org/10.1021/op5000489
https://doi.org/10.1021/op5000489
Autor:
Gavin W. Stewart, Jeremy P. Scott, Andrew W. Gibson, Stephen P. Keen, Adam D. Gammack Yamagata, Michael Shevlin
Publikováno v:
Organic Letters. 14:5440-5443
A novel synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of the corresponding β-aryloxy-α,β-unsaturated esters has been demonstrated. Bis(norbornadiene)rhodium(I) tetrafluoroborate (1 mol %) and Walphos W008-1 were used to gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a0d21f0d0bd8a8dc5b63558e96e53
https://doi.org/10.1021/ol302518y
https://doi.org/10.1021/ol302518y
Autor:
Simon Adrian Johnson, Mary M. Kim, Fred J. Fleitz, Khateeta M. Emerson, Ephraim M. Bassan, Carl A. Baxter, Gregory L. Beutner, Jeffrey T. Kuethe, Leonard William, Stephen P. Keen, Peter R. Mullens, Nobuyoshi Yasuda, Christopher Roberge, Daniel J. Muzzio
Publikováno v:
Organic Process Research & Development. 16:87-95
A six-step route starting from a readily available vinyl boronate was identified to produce an enantioenriched cyclopropanol in an overall 16% yield. Key steps involve the use of lithium acetylide-ethylene diamine complex 5 and an enzymatic resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fe79d87e5f339f77b907de6f33b712
https://doi.org/10.1021/op2002497
https://doi.org/10.1021/op2002497
Autor:
Paul Fernandez, Weifeng Hu, Peter Sajonz, Karel J. M. Brands, Jennifer R. Foley, Peter R. Mullens, Lushi Tan, George Zhou, Nadine Bremeyer, Robert D. Wilson, Sarah E. Brewer, Daniel J. Muzzio, Guoyue Zhou, Debra J. Wallace, Khateeta M. Emerson, Richard Desmond, Stephen P. Keen, Carl A. Baxter
Publikováno v:
Organic Process Research & Development. 15:831-840
Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f282e65dc38e0c3e06307cc29e3d06
https://doi.org/10.1021/op2000783
https://doi.org/10.1021/op2000783
Autor:
Antony J. Davies, Jason D. Katz, Andrew W. Gibson, Sarah E. Brewer, Stephen P. Keen, Simon E. Hamilton, Debra J. Wallace, Jeremy P. Scott, Christopher Wise, Cameron J. Cowden, Peter R. Mullens, Gavin W. Stewart, Karel M. J. Brands, John S. Edwards
Publikováno v:
Organic Process Research & Development. 14:849-858
A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd9af518581b577a8ae5e2950a75d4a
https://doi.org/10.1021/op100101q
https://doi.org/10.1021/op100101q
Autor:
Antony J. Davies, Karel M. J. Brands, Sarah E. Brewer, Robert D. Wilson, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Ulf-H. Dolling, David Hands, Stephen P. Keen, Robert A. Reamer, Steven F. Oliver
Publikováno v:
The Journal of Organic Chemistry. 71:3086-3092
A practical asymmetric synthesis of the gamma-secretase inhibitor (-)-1 is described. As the key transformation, a highly diastereoselective intramolecular nitrile oxide cycloaddition forms the hexahydrobenzisoxazole core of 3 in four operations. Oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f032407119fcad06ff980eed48c48c77
https://doi.org/10.1021/jo060033i
https://doi.org/10.1021/jo060033i
Autor:
Steven M. Weinreb, Stephen P. Keen
Publikováno v:
Tetrahedron Letters. 41:4307-4310
Two different routes have been developed to prepare uracils related to that found in the marine hepatotoxin cylindrospermopsin starting from α,β-unsaturated esters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ba6f8d6757d44f8d234c9a8ed4b9e7
https://doi.org/10.1016/s0040-4039(00)00633-x
https://doi.org/10.1016/s0040-4039(00)00633-x