Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephen P. Jung"'
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Publikováno v:
eLife, Vol 11 (2022)
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectr
Externí odkaz:
https://doaj.org/article/e2f24e41f41645fe97c9ca6615d7120b
Autor:
Elisabetta Morini, Anil Chekuri, Emily M. Logan, Jessica M. Bolduc, Emily G. Kirchner, Monica Salani, Aram J. Krauson, Jana Narasimhan, Vijayalakshmi Gabbeta, Shivani Grover, Amal Dakka, Anna Mollin, Stephen P. Jung, Xin Zhao, Nanjing Zhang, Sophie Zhang, Michael Arnold, Matthew G. Woll, Nikolai A. Naryshkin, Marla Weetall, Susan A. Slaugenhaupt
Publikováno v:
The American Journal of Human Genetics. 110:531-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca971e4cab6c002ffc2931002b457f68
https://doi.org/10.1016/j.ajhg.2023.01.019
https://doi.org/10.1016/j.ajhg.2023.01.019
Autor:
Elisabetta Morini, Anil Chekuri, Emily M. Logan, Jessica M. Bolduc, Emily G. Kirchner, Monica Salani, Aram J. Krauson, Jana Narasimhan, Vijayalakshmi Gabbeta, Shivani Grover, Amal Dakka, Anna Mollin, Stephen P. Jung, Xin Zhao, Nanjing Zhang, Sophie Zhang, Michael Arnold, Matthew G. Woll, Nikolai A. Naryshkin, Marla Weetall, Susan A. Slaugenhaupt
Familial Dysautonomia (FD) is a rare neurodegenerative disease caused by a splicing mutation in the Elongator complex protein 1 gene (ELP1). This mutation leads to the skipping of exon 20 and a tissue-specific reduction of ELP1 protein, mainly in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a64b71d62fa258620dca926a0dd28fe
https://doi.org/10.1101/2022.11.04.515198
https://doi.org/10.1101/2022.11.04.515198
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242c3ecb2516113bcfac9a95f12d9626
https://doi.org/10.7554/elife.67447.sa2
https://doi.org/10.7554/elife.67447.sa2
Autor:
Song Huang, Jason D. Graci, Paul Ingravallo, Anthony Turpoff, Neil Gregory Almstead, John Pichardo, Nanjing Zhang, Joseph M. Colacino, F. George Njoroge, Yalei Liu, Zhengxian Gu, Marla Weetall, Frederick C. Lahser, Stephen P. Jung, Gary Mitchell Karp, Amin A. Nomeir, Xiaoyan Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:594-601
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f2dde02f0aa0ffaf8e4d127e01fcf0
https://doi.org/10.1016/j.bmcl.2015.11.065
https://doi.org/10.1016/j.bmcl.2015.11.065
Autor:
Xiao Tong, John Pichardo, Frederick C. Lahser, Stephen P. Jung, Jason D. Graci, Joseph M. Colacino, Zhengxian Gu
Publikováno v:
Antimicrobial Agents and Chemotherapy
PTC725 is a small molecule NS4B-targeting inhibitor of hepatitis C virus (HCV) genotype (gt) 1 RNA replication that lacks activity against HCV gt2. We analyzed the Los Alamos HCV sequence database to predict susceptible/resistant HCV gt's according t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee25a6ee5c13d13eea8c2b72037c757
https://pubmed.ncbi.nlm.nih.gov/27620477
https://pubmed.ncbi.nlm.nih.gov/27620477
Autor:
F. George Njoroge, Amin A. Nomeir, Xin Zhao, Guangming Chen, Stephen P. Jung, Joseph M. Colacino, Neil Gregory Almstead, Zhengxian Gu, Marla Weetall, Chunshi Li, Hongyu Ren, Nanjing Zhang, Anthony Turpoff, Jason D. Graci, Steven D. Paget, Frederick C. Lahser, Gary Mitchell Karp, William Joseph Lennox
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
A structure–activity relationship investigation of various 6-(azaindol-2-yl)pyridine-3-sulfonamides using the HCV replicon cell culture assay led to the identification of a potent series of 7-azaindoles that target the hepatitis C virus NS4B. Compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ee7450843f81a2d826e80272bb95f
https://pubmed.ncbi.nlm.nih.gov/25613678
https://pubmed.ncbi.nlm.nih.gov/25613678
Publikováno v:
The EMBO Journal. 20:6443-6452
B-cell differentiation is accompanied by a dramatic increase in cytoplasmic accumulation and stability of the IgM heavy chain (mu) secretory mRNA. Despite considerable effort, the mechanism is unknown. We have identified three short motifs upstream o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1985d7dcd60d088c7d85faa736754737
https://doi.org/10.1093/emboj/20.22.6443
https://doi.org/10.1093/emboj/20.22.6443
Autor:
Hongyu Ren, Jason D. Graci, Srikanth Venkatraman, William Joseph Lennox, Anna Mollin, Anthony Turpoff, Josephine Sheedy, Guangming Chen, Stephen P. Jung, Amin A. Nomeir, Joseph M. Colacino, Xiaoyan Zhang, Zhengxian Gu, Jin Zhu, Ramesh Kakarla, Frederick C. Lahser, Gary Mitchell Karp, Song Huang, Valerie Clausen, Neil Gregory Almstead, Nanjing Zhang, Yingcong Zheng, Ronggang Liu, F. George Njoroge, Marla Weetall, Christie Morrill, Chunshi Li
Publikováno v:
Journal of medicinal chemistry. 57(5)
A novel, potent, and orally bioavailable inhibitor of hepatitis C RNA replication targeting NS4B, compound 4t (PTC725), has been identified through chemical optimization of the 6-(indol-2-yl)pyridine-3-sulfonamide 2 to improve DMPK and safety propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e05cdc75e0538dce5c840befd524ffe
https://pubmed.ncbi.nlm.nih.gov/24266880
https://pubmed.ncbi.nlm.nih.gov/24266880
Autor:
Xiao Tong, Frederick C. Lahser, Stuart W. Peltz, Shaotang Liu, Patricia McMonagle, Song Huang, Stephen P. Jung, Jin Zhu, Jamie Breslin, Joseph M. Colacino, Neil Gregory Almstead, Gary Mitchell Karp, Robert Ralston, Jason D. Graci, Ellen Xia, Zhengxian Gu, Marla Weetall, Amin A. Nomeir, James H. Crona
Publikováno v:
Antimicrobial agents and chemotherapy. 57(7)
While new direct-acting antiviral agents for the treatment of chronic hepatitis C virus (HCV) infection have been approved, there is a continued need for novel antiviral agents that act on new targets and can be used in combination with current thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f466a47fb711e2adefe547001bd80a
https://pubmed.ncbi.nlm.nih.gov/23629699
https://pubmed.ncbi.nlm.nih.gov/23629699