Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Stephen P. Holly"'
Autor:
Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3818-3828 (2019)
Abstract: We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC)
Externí odkaz:
https://doaj.org/article/cfd11219f3594d06852884f8acda0943
Publikováno v:
Metabolites, Vol 11, Iss 1, p 41 (2021)
The primacy of lipids as essential components of cellular membranes is conserved across taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are also increasingly recognized as important signaling molecules with div
Externí odkaz:
https://doaj.org/article/35bd377dd887436e8cf22189820de75c
Autor:
Ling Xie, Cui Liu, Li Wang, Harsha P. Gunawardena, Yanbao Yu, Ruyun Du, Debra J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen P. Holly, Leslie V. Parise, Yisong Y. Wan, Jenny P. Ting, Xian Chen
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 678-688 (2013)
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specific chromatin modifications regulate inflammation, the role
Externí odkaz:
https://doaj.org/article/3c25ab3ac97b41b2bfa7c0f33761c676
Autor:
Amanda Brechko, Michael R. Jiroutek, Kyla Jones, Bonnie Brenseke, Donald C. Maharty, James Cappola, Stephen P. Holly
Background Some patients with COVID-19 develop life-threatening thrombotic complications including myocardial infarction, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, and ischemic stroke. These inflammatory and hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbde3408e6716675d90f6c483dcba82
Autor:
Putianqi Wang, Ruchi G. Patil, Ziqiang Guan, Ling Lin, Wolfgang Bergmeier, Brian C. Cooley, Leslie V. Parise, Nidhi Gera, Raymond Piatt, Stephen P. Holly, Tina M. Leisner, Rinku Majumder, Hammodah R. Alfar, Alexander Wilson
Publikováno v:
Blood Advances. 3:3818-3828
We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73c83ee7be7de4b882ee212c1c0e93
https://doi.org/10.1182/bloodadvances.2018030767
https://doi.org/10.1182/bloodadvances.2018030767
Publikováno v:
Metabolites
Metabolites, Vol 11, Iss 41, p 41 (2021)
Metabolites, Vol 11, Iss 41, p 41 (2021)
The primacy of lipids as essential components of cellular membranes is conserved across taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are also increasingly recognized as important signaling molecules with div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc328072f71ce43bd0e6f4e02cf8a67
http://europepmc.org/articles/PMC7827237
http://europepmc.org/articles/PMC7827237
Autor:
David S. Lawrence, Qunzhao Wang, Colin P. O'Banion, Melanie A. Priestman, Luong T. Nguyen, Stephen P. Holly, Leslie V. Parise
Publikováno v:
Angewandte Chemie International Edition. 55:950-954
Although peptide-based therapeutics are finding increasing application in the clinic, extensive structural modification is typically required to prevent their rapid degradation by proteases in the blood. We have evaluated the ability of erythrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b643ba26f276098d0036ad4f044e9a5
https://doi.org/10.1002/anie.201508767
https://doi.org/10.1002/anie.201508767
Autor:
Stephen P. Holly
Affinity regulation of integrin αIIbβ3 for fibrinogen by inside-out signaling plays a critical role in hemostasis. Calcium and diacylglycerol (DAG)-regulated guanine nucleotide exchange factor I (CalDAG-GEFI) was identified as a Rap1-activating mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce36224e9d2d4c2503e3ef9f2599eba0
https://europepmc.org/articles/PMC5146748/
https://europepmc.org/articles/PMC5146748/
Autor:
Stephen P. Holly, Yanbao Yu, Yisong Y. Wan, Ruyun Du, Li Wang, Xian Chen, Jenny P.-Y. Ting, Debra J. Taxman, Penggao Dai, Zhen Yan, Harsha P. Gunawardena, Cui Liu, Ling Xie, Jing Yu, Leslie V. Parise
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 678-688 (2013)
SummaryMyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specific chromatin modifications regulate inflammation, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b509b165cfffd448b97c66e05628d8
http://www.sciencedirect.com/science/article/pii/S2211124713000533
http://www.sciencedirect.com/science/article/pii/S2211124713000533
Autor:
Stephen P. Holly, Leslie V. Parise
Publikováno v:
Current Drug Targets. 12:1859-1870
Platelets are dynamic blood cells that form life-threatening thrombi in response to a variety of pathological conditions such as atherosclerosis, diabetes, metastatic cancer, sickle cell disease and obesity. These thrombi can lead directly to myocard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1c8e3a6eeae8e02577165ba1d93c88
https://doi.org/10.2174/138945011797635795
https://doi.org/10.2174/138945011797635795