Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Stephen P H, Alexander"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Extracellular signal-regulated kinases (ERKs) are important signaling mediators in mammalian cells and, as a result, one of the major areas of research focus. The detection and quantification of ERK phosphorylation as an index of activati
Externí odkaz:
https://doaj.org/article/813023d11c194669995dc0f264813a80
Autor:
Jane F. Armstrong, Brice Campo, Stephen P. H. Alexander, Lauren B. Arendse, Xiu Cheng, Anthony P. Davenport, Elena Faccenda, David A. Fidock, Karla P. Godinez‐Macias, Simon D. Harding, Nobutaka Kato, Marcus C. S. Lee, Madeline R. Luth, Ralph Mazitschek, Nimisha Mittal, Jacquin C. Niles, John Okombo, Sabine Ottilie, Charisse Flerida A. Pasaje, Alexandra S. Probst, Mukul Rawat, Frances Rocamora, Tomoyo Sakata‐Kato, Christopher Southan, Michael Spedding, Mark A. Tye, Tuo Yang, Na Zhao, Jamie A. Davies
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add3b14927d732e9ca8df1a8867cb1cb
https://doi.org/10.1111/bph.16144
https://doi.org/10.1111/bph.16144
Publikováno v:
Connolly, C, Alexander, S P H, Davies, J A & Spedding, M 2022, ' Environmental pharmacology – dosing the environment : IUPHAR review 36 ', British Journal of Pharmacology, vol. 179, no. 23, pp. 5172-5179 . https://doi.org/10.1111/bph.15933
Pesticide action is predominantly measured as a toxicological outcome, with pharmacological impact of sublethal doses on bystander species left largely undocumented. Likewise, chronic exposure, which often results in responses different from acute ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ee9f35e2ac46d94ffce89cc8ef73fa
Autor:
Michael J. Curtis, Stephen P. H. Alexander, Giuseppe Cirino, Christopher H. George, David A. Kendall, Paul A. Insel, Angelo A. Izzo, Yong Ji, Reynold A. Panettieri, Hemal H. Patel, Christopher G. Sobey, S. Clare Stanford, Phil Stanley, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Amrita Ahluwalia
Scientists who plan to publish in British Journal of Pharma- cology (BJP) must read this article before undertaking a study. This editorial provides guidance for the design of experiments. We have published previously two guidance documents on experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e98ed29d79d8a680437f9b877ec192d
https://cronfa.swan.ac.uk/Record/cronfa60174
https://cronfa.swan.ac.uk/Record/cronfa60174
Autor:
Peter Kolb, Terry Kenakin, Stephen P. H. Alexander, Marcel Bermudez, Laura M. Bohn, Christian S. Breinholt, Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, Rick R. Neubig, H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, Martha E. Sommer, David E. Gloriam
Publikováno v:
Kolb, P, Kenakin, T, Alexander, S P H, Bermudez, M, Bohn, L M, Breinholt, C S, Bouvier, M, Hill, S J, Kostenis, E, Martemyanov, K A, Neubig, R R, Onaran, H O, Rajagopal, S, Roth, B L, Selent, J, Shukla, A K, Sommer, M E & Gloriam, D E 2022, ' Community guidelines for GPCR ligand bias : IUPHAR review 32 ', British Journal of Pharmacology, vol. 179, no. 14, pp. 3651-3674 . https://doi.org/10.1111/bph.15811
GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5effccabe4adda3038e382873dc7eb47
http://hdl.handle.net/10230/53439
http://hdl.handle.net/10230/53439
Autor:
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong
Publikováno v:
Alexander, Stephen Ph; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair; Peters, John A; Veale, Emma L; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Pawson, Adam J; Southan, Christopher; Davies, Jamie A; Boison, Detlev; Burns, Kathryn Elisa; Dessauer, Carmen; Gertsch, Jürg; Helsby, Nuala Ann; Izzo, Angelo A; Koesling, Doris; Ostrom, Rennolds; ... (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British journal of pharmacology, 178(Suppl. 1), S313-S411. Wiley 10.1111/bph.15542
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121ee1cf530f801dfca85582efb2536
https://boris.unibe.ch/161549/1/bph.15542.pdf
https://boris.unibe.ch/161549/1/bph.15542.pdf
Autor:
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Laura Amarosi, Catriona M. H. Anderson, Philip Mark Beart, Stefan Broer, Paul A. Dawson, Bruno Hagenbuch, James R. Hammond, Jules C Hancox, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Gavin Stewart, David T. Thwaites, Tiziano Verri
Publikováno v:
British journal of pharmacology, 178(S1), S412-S513. Wiley-Blackwell
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91f0a1d41af24ebc7160ba9917a0ccc
https://pubmed.ncbi.nlm.nih.gov/34529826
https://pubmed.ncbi.nlm.nih.gov/34529826
Autor:
Yousra, Adel, Stephen P H, Alexander
Publikováno v:
Advances in experimental medicine and biology. 1264
Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::518ce7e843ed3517414adcf047bef5c8
https://pubmed.ncbi.nlm.nih.gov/33332001
https://pubmed.ncbi.nlm.nih.gov/33332001
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58926 (2013)
Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of learn
Externí odkaz:
https://doaj.org/article/0157a0cfbbe34f9e8622c3096dd9c351
Autor:
Nahed, Alharthi, Peter, Christensen, Wafa, Hourani, Catherine, Ortori, David A, Barrett, Andrew J, Bennett, Victoria, Chapman, Stephen P H, Alexander
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(11)
Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::677899536f372104a61c99ccb92ca78a
https://pubmed.ncbi.nlm.nih.gov/30591150
https://pubmed.ncbi.nlm.nih.gov/30591150