Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Stephen P, Schoenberger"'
Autor:
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle, Samantha M. Hall, Rukman R. Thota, Karla S. Zavala, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Ezra E. W. Cohen, Bjoern Peters, Stephen P. Schoenberger
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
Therapeutic benefit to immune checkpoint blockade (ICB) is currently limited to the subset of cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the spontaneous recognition of neoantigens (NeoAg) by autologous T cells.
Externí odkaz:
https://doaj.org/article/2a9a0edba8ed47f8a8305d3beb9941be
Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
Autor:
Sayuri Miyauchi, Sangwoo S. Kim, Riley N. Jones, Lin Zhang, Kripa Guram, Sonia Sharma, Stephen P. Schoenberger, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112508- (2023)
Summary: The role that human papillomavirus (HPV) oncogenes play in suppressing responses to immunotherapy in cancer deserves further investigation. In particular, the effects of HPV E5 remain poorly understood relative to E6 and E7. Here, we demonst
Externí odkaz:
https://doaj.org/article/0ab3a92f30554844b0725683d435e893
Autor:
Spencer E. Brightman, Martin S. Naradikian, Rukman R. Thota, Angelica Becker, Leslie Montero, Milad Bahmanof, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Bjoern Peters, Ezra E.W. Cohen, Aaron M. Miller, Stephen P. Schoenberger
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
CD4+ T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor
Externí odkaz:
https://doaj.org/article/269a1b54d04f495aa248feef28743e01
Autor:
Zeynep Koşaloğlu-Yalçın, Jenny Lee, Jason Greenbaum, Stephen P. Schoenberger, Aaron Miller, Young J. Kim, Alessandro Sette, Morten Nielsen, Bjoern Peters
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103850- (2022)
Summary: Many steps of the MHC class I antigen processing pathway can be predicted using computational methods. Here we show that epitope predictions can be further improved by considering abundance levels of peptides' source proteins. We utilized bi
Externí odkaz:
https://doaj.org/article/dee22334be9c400f97f173efaf88bffb
Autor:
Zeynep Koşaloğlu-Yalçın, Nina Blazeska, Hannah Carter, Morten Nielsen, Ezra Cohen, Donald Kufe, Jose Conejo-Garcia, Paul Robbins, Stephen P. Schoenberger, Bjoern Peters, Alessandro Sette
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recent years have witnessed a dramatic rise in interest towards cancer epitopes in general and particularly neoepitopes, antigens that are encoded by somatic mutations that arise as a consequence of tumorigenesis. There is also an interest in the spe
Externí odkaz:
https://doaj.org/article/68daada88ab8452d8d87ce6fc0b580b2
Autor:
Joseph S. Dolina, Joey Lee, Ryan Q. Griswold, Lara Labarta-Bajo, Sumetha Kannan, Jason A. Greenbaum, Nawal Bahia El Idrissi, Margot J. Pont, Michael Croft, Stephen P. Schoenberger
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: CD4+ T lymphocytes are crucial for controlling a range of innate and adaptive immune effectors. For CD8+ cytotoxic T lymphocyte (CTL) responses, CD4+ T cells can function as helpers (TH) to amplify magnitude and functionality or as regulator
Externí odkaz:
https://doaj.org/article/a440ac19a50c41eb8d3abc0f77cee26c
Autor:
Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A. Davies, Reinhard Dummer, Soldano Ferrone, Thomas F. Gajewski, Claus Garbe, Jason J. Luke, Francesco M. Marincola, Giuseppe Masucci, Janice M. Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A. Postow, Stephen P. Schoenberger, Ena Wang, Magdalena Thurin
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape was revolutionised with the appr
Externí odkaz:
https://doaj.org/article/2d1e71fc5d4043f99a44acdb17e481d6
Autor:
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle, Samantha M. Hall, Rukman R. Thota, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Ezra E.W. Cohen, Bjoern Peters, Stephen P. Schoenberger
Publikováno v:
bioRxiv
Therapeutic benefit to immune checkpoint blockade (ICB) is currently limited to the subset of cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the spontaneous recognition of neoantigens (NeoAg) by autologous T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458ca4cdb3519a9775be1f21081abf43
https://europepmc.org/articles/PMC10187312/
https://europepmc.org/articles/PMC10187312/
Autor:
Rebekah R. White, Stephen P. Schoenberger, Aaron M. Miller, Dennis A. Carson, Diego Vicente, Thomas C. Whisenant, Tomoko Hayashi, Partha Ray, Jayanth S. Shankara Narayanan
List of KPC Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a219b51f139231f27f0a7922f4f0af7
https://doi.org/10.1158/2326-6066.22542115.v1
https://doi.org/10.1158/2326-6066.22542115.v1
Autor:
Rebekah R. White, Stephen P. Schoenberger, Aaron M. Miller, Dennis A. Carson, Diego Vicente, Thomas C. Whisenant, Tomoko Hayashi, Partha Ray, Jayanth S. Shankara Narayanan
Supplementary Figures 1-6 and Supplementary Tables 1 and 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b24330db0f7104b12d2e2b07c4eb19
https://doi.org/10.1158/2326-6066.22542112.v1
https://doi.org/10.1158/2326-6066.22542112.v1