Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Stephen P, Saville"'
Autor:
Jesus A. Romo, Hao Zhang, Hong Cai, David Kadosh, Julia R. Koehler, Stephen P. Saville, Yufeng Wang, Jose L. Lopez-Ribot
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT The opportunistic pathogenic fungus Candida albicans can cause devastating infections in immunocompromised patients. Its ability to undergo a morphogenetic transition from yeast to filamentous forms allows it to penetrate tissues and damage
Externí odkaz:
https://doaj.org/article/555a4c41abd14bd7900c3543726bc2d1
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Fungal and bacterial populations coexist in the oral cavity, frequently forming mixed-species biofilms that complicate treatment against polymicrobial infections. However, despite relevance to oral health, the bidirectional interactions betw
Externí odkaz:
https://doaj.org/article/26061f43e1e54c40860401356ba52daf
Autor:
Sandra M. Cardona, Sangwon V. Kim, Kaira A. Church, Vanessa O. Torres, Ian A. Cleary, Andrew S. Mendiola, Stephen P. Saville, Stephanie S. Watowich, Jan Parker-Thornburg, Alejandro Soto-Ospina, Pedronel Araque, Richard M. Ransohoff, Astrid E. Cardona
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered
Externí odkaz:
https://doaj.org/article/76a2d98136d74fc3b8f720a970c7379d
Autor:
Jesus A. Romo, Christopher G. Pierce, Marisol Esqueda, Chiung-Yu Hung, Stephen. P. Saville, Jose L. Lopez-Ribot
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
We have previously identified a small molecule compound, N-[3-(allyloxy)-phenyl]-4-methoxybenzamide (9029936), that exerts potent inhibitory activity against filamentation and biofilm formation by the Candida albicans SC5314 strain and represents a l
Externí odkaz:
https://doaj.org/article/d778c1bfd740470587eb7f7dbbd37c03
Autor:
Jesus A. Romo, Christopher G. Pierce, Ashok K. Chaturvedi, Anna L. Lazzell, Stanton F. McHardy, Stephen P. Saville, Jose L. Lopez-Ribot
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Candida albicans remains the main etiologic agent of candidiasis, the most common fungal infection and now the third most frequent infection in U.S. hospitals. The scarcity of antifungal agents and their limited efficacy contribute to the un
Externí odkaz:
https://doaj.org/article/69248be2b72a44429a21da8645afd8de
Publikováno v:
Journal of Fungi, Vol 5, Iss 1, p 22 (2019)
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections. Previo
Externí odkaz:
https://doaj.org/article/991e0749770b46d081dea9ac93871902
Autor:
Ian A. Cleary, Stephen P. Saville
Publikováno v:
Mycopathologia. 186:103-107
In Candida albicans, geldanamycin treatment inhibits the essential chaperone Hsp90 and induces a change from yeast to filamentous morphology, likely by impeding cell cycle progression and division. However, filaments formed by wild-type cells upon ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b8fa157a67932dff977881a9a89e39
https://doi.org/10.1007/s11046-020-00511-3
https://doi.org/10.1007/s11046-020-00511-3
Autor:
Stephen P, Saville, Ian A, Cleary
Publikováno v:
Mycopathologia. 186(1)
In Candida albicans, geldanamycin treatment inhibits the essential chaperone Hsp90 and induces a change from yeast to filamentous morphology, likely by impeding cell cycle progression and division. However, filaments formed by wild-type cells upon ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a8432f3349de27d054d16640490e950
https://pubmed.ncbi.nlm.nih.gov/33389485
https://pubmed.ncbi.nlm.nih.gov/33389485
Autor:
Ashok K Chaturvedi, Anna L Lazzell, Stephen P Saville, Floyd L Wormley, Carlos Monteagudo, Jose L Lopez-Ribot
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20449 (2011)
Understanding the pathogenesis of infectious disease requires the examination and successful integration of parameters related to both microbial virulence and host responses. As a practical and powerful method to control microbial gene expression, in
Externí odkaz:
https://doaj.org/article/3bb94cde87fd46d4988ff9c45b72af73
Autor:
Hong Cai, Jose L. Lopez-Ribot, Hao Zhang, Stephen P. Saville, Yufeng Wang, Julia Koehler, Jesus A. Romo, David Kadosh
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
mSphere
mSphere, Vol 4, Iss 5, p e00620-19 (2019)
mSphere
mSphere, Vol 4, Iss 5, p e00620-19 (2019)
These results from whole-genome transcriptional profiling provide further insights into the biological activity and mode of action of a small-molecule inhibitor of C. albicans filamentation. This information will assist in the development of novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923bd907f72758e0fd0c09d8226688e6
https://journals.asm.org/doi/10.1128/mSphere.00620-19
https://journals.asm.org/doi/10.1128/mSphere.00620-19