Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Stephen P, Diggle"'
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of genomic diversification and evolutionary trade-offs in antimicro
Externí odkaz:
https://doaj.org/article/7b74583486714893a47a6b6a5f636bb8
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Chronic, highly antibiotic-resistant infections in cystic fibrosis (CF) lungs contribute to increasing morbidity and mortality. Pseudomonas aeruginosa, a common CF pathogen, exhibits resistance to multiple antibiotics, contributing to antimi
Externí odkaz:
https://doaj.org/article/747b98ce2eef482c8eaf355ee9e7b694
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Solventogenic clostridia represent a diverse group of anaerobic, spore-forming bacteria capable of producing acetone, butanol and ethanol through their unique biphasic metabolism. An intrinsic problem with these organisms however is their tendency to
Externí odkaz:
https://doaj.org/article/d48c08edafee46cca0214a0068821778
Autor:
Sheyda Azimi, Jacob Thomas, Sara E. Cleland, Jennifer E. Curtis, Joanna B. Goldberg, Stephen P. Diggle
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Bacteria live in spatially organized aggregates during chronic infections, where they adapt to the host environment, evade immune responses, and resist therapeutic interventions. Although it is known that environmental factors such as polyme
Externí odkaz:
https://doaj.org/article/af1ea9cac38f4baf917914f59eb4b5b5
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
R-pyocins have potential as alternative therapeutics against Pseudomonas aeruginosaP. aeruginosaP. aeruginosa
Externí odkaz:
https://doaj.org/article/b90919ab36064a51b6a2b61131188456
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa infections are difficult to treat due to a number of antibiotic resistance mechanisms and th
Externí odkaz:
https://doaj.org/article/6136d509776247da8609f2a3de51967f
Pseudomonas aeruginosais a prevalent pathogen in cystic fibrosis (CF) lungs which displays strong resistance to various antibiotic classes, contributing to antimicrobial resistance (AMR).P aeruginosapopulations in CF lungs exhibit considerable geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da578e10f3ac3fcd0823059c5d2390c6
https://doi.org/10.1101/2023.04.26.538445
https://doi.org/10.1101/2023.04.26.538445
Autor:
Katherine L. Cook, David R. Soto-Pantoja, Stephen P. Diggle, Shaina A. Yates-Alston, Nicole Levi-Polyachenko, Edward A. Levine, Marissa Howard-McNatt, Adam S. Wilson, Kenysha Y.J. Clear, Christine Velazquez, Alaa Bawaneh, Akiko Chiba
Breast tumors have their own specific microbiota, distinct from normal mammary gland tissue. Patients with breast cancer that present with locally advanced disease often undergo neoadjuvant chemotherapy to reduce tumor size prior to surgery to allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce07e9c95e2ecf0b37289ea1c2999e4e
https://doi.org/10.1158/1541-7786.c.6541044.v1
https://doi.org/10.1158/1541-7786.c.6541044.v1
Autor:
Katherine L. Cook, David R. Soto-Pantoja, Stephen P. Diggle, Shaina A. Yates-Alston, Nicole Levi-Polyachenko, Edward A. Levine, Marissa Howard-McNatt, Adam S. Wilson, Kenysha Y.J. Clear, Christine Velazquez, Alaa Bawaneh, Akiko Chiba
Obesity influences breast tumor microbiota populations. Breast tumor 16S sequencing results were stratified based upon patient body mass index (BMI). Tumor bacterial populations from non-obese patients with a BMI of 20-27 (n=9) were compared with bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c577226eb8b99608dd5b4fe380b729
https://doi.org/10.1158/1541-7786.22515330.v1
https://doi.org/10.1158/1541-7786.22515330.v1
Publikováno v:
Microbiology (Reading)
Pseudomonas aeruginosa uses quorum sensing (QS) to coordinate the expression of multiple genes necessary for establishing and maintaining infection. It has previously been shown that lasR QS mutations frequently arise in cystic fibrosis (CF) lung inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0f027a01e38444df238bbdab94ead5
https://doi.org/10.1099/mic.0.001265
https://doi.org/10.1099/mic.0.001265