Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stephen N. Mitchell"'
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Autor:
Wesley H. Anderson, Paul L. Ornstein, Vladamir Tolstikov, Guy Carter, Renhua Li, Brian J. Eastwood, Carl D Overshiner, Alexander Nikolayev, Kurt Rasmussen, Stephen Smith, Gary Gilmour, Stephen Swanson, Linda M. Rorick-Kehn, Xia Li, Keith A. Wafford, John T. Catlow, Jeffrey M. Witkin, Stephen N. Mitchell, Charles H. Mitch, Ming-Shang Kuo, Jennifer Li, James A. Monn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:68-86
The ability of the N-methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic responses in rodents el
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Autor:
James A. Monn, Kurt Rasmussen, Guy Carter, Stephen N. Mitchell, Linda M. Rorick-Kehn, Jeffrey M. Witkin, Bryan G. Johnson, Xia Li, Darryle D. Schoepp, Carl D Overshiner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 358:71-82
Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering of synaptogenesis transductio
Autor:
Arjan Blokland, Sarah Hescham, Stephen N. Mitchell, Ali Jahanshahi, Trevor Sharp, Yasin Temel, Guy Carter, Judith Schweimer
Publikováno v:
Brain Structure & Function, 221(8). Springer
Brain Structure & Function
Brain Structure & Function
Deep brain stimulation (DBS) of the fornix has gained interest as a potential therapy for advanced treatment-resistant dementia, yet the mechanism of action remains widely unknown. Previously, we have reported beneficial memory effects of fornix DBS
Autor:
Michelle M Menezes, Jeffrey M. Witkin, Kjell A. Svensson, Brian J. Eastwood, Eyassu Chernet, Michael J. O'Neill, Julie F. Falcone, Keith A. Wafford, Hong Wang, Linda K. Thompson, John W. Ryder, Stephen N. Mitchell, Junliang Hao, John Mehnert Schaus, Robert F. Bruns, Alex J. Harper, Meghane E. Masquelin, Deanna L Maren, Xia Li, Tracey K. Murray, Charles R. Yang, Elaine Shanks, Jason Katner, Linli Zhang, Guy Carter, James P. Beck, Patrick L. Love
Publikováno v:
Neuropharmacology. 128
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species difference in affinity for DETQ, all rodent experiments used transgenic mice expressing the
Autor:
Jon K. Reel, Akihiko Kato, Gary Gilmour, Keith A. Wafford, Warren J. Porter, Jennifer Li, Brian J. Eastwood, Stephen N. Mitchell, Guy Carter, Scott D. Gleason, Wesley Seidel, Kevin Matthew Gardinier, Jeffrey M. Witkin, Andrew McCarthy
Publikováno v:
Neuropharmacology. 126
6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has bee
Autor:
Pamela Ohman Strickland, Stephen N. Mitchell, Sarah Mueller-Steiner, Elizabeth Tarasewicz, Samnang Tep, Kathryn Hilton, Akash Datwani, Michael J. O'Neill, Manuel Buttini, Kalpana M. Merchant, Kavita Prasad, Eric K. Richfield
Publikováno v:
European Journal of Neuroscience. 33:642-656
A consensus about the functions of human wild-type or mutated α-synuclein (αSYN) is lacking. Both forms of αSYN are implicated in Parkinson's disease, whereas the wild-type form is implicated in substance abuse. Interactions with other cellular pr
Autor:
Carlos Montero, Lorna Hayhurst, Leslie Walton, Stephen N. Mitchell, Rosemarie Tomlinson, Louise Wallace, Graham Henry Timms, Jeremy Gilmore, Jeremy Findlay, Jane Cooper, John R. Boot, Richard J. Broadmore, Alicia Marcos, Ana B. Bueno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3344-3348
SAR around a known molecule with dual 5-HT(1D) antagonist and 5-HT(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT(1B), alpha(1), a
Autor:
K Diker, Graham Henry Timms, Chad Nolan Wolfe, John Joseph Masters, Simon James Richards, Serge Louis Boulet, Harris, Manuel Javier Cases-Thomas, Peter Thaddeus Gallagher, Jeremy Gilmore, Jeremy Findlay, Maria Ann Whatton, L. Delhaye, Virginia Ann Wood, Barry Peter Clark, M Naik, SM Smith, John Fairhurst, Robin G. Simmonds, Boot, Stephen N. Mitchell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2714-2718
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.