Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephen N. Greszler"'
Publikováno v:
Organic Letters. 24:7305-7308
ABBV-3748 is a C2 corrector for the treatment of cystic fibrosis profiled among AbbVie's CFTR portfolio. A decagram-scale enabling asymmetric synthesis is described which addresses numerous shortcomings of the original route. Highlights include an In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f99f79aab586861765aa8a67a74c1e
https://doi.org/10.1021/acs.orglett.2c02729
https://doi.org/10.1021/acs.orglett.2c02729
Publikováno v:
ACS omega. 7(48)
A-9758 is an inverse agonist of retinoic acid-related orphan receptor γt with well-characterized in vitro and in vivo anti-inflammatory activity. A chromatography-free decagram-scale synthesis of this compound was developed to support pre-clinical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aba6fa773ac518fc779f9f8042c3aab
https://pubmed.ncbi.nlm.nih.gov/36506123
https://pubmed.ncbi.nlm.nih.gov/36506123
Publikováno v:
The Journal of organic chemistry. 85(11)
A scalable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82f09dfffb5a6a6a977adabaa3ed289a
https://pubmed.ncbi.nlm.nih.gov/32374998
https://pubmed.ncbi.nlm.nih.gov/32374998
Publikováno v:
Organic Letters. 18:2624-2627
The pentacyclic core skeleton of the cortistatins has been prepared in a stereoselective fashion by strategic use of an alkoxide-directed metallacycle-mediated annulative cross-coupling. This metal-centered tandem reaction delivers a polyunsaturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e86507e8cd529da92383d83a4508b77
https://doi.org/10.1021/acs.orglett.6b01048
https://doi.org/10.1021/acs.orglett.6b01048
Publikováno v:
Organic Letters. 11:827-830
Lanthanide triisopropoxides catalyze a rapid, tandem MPV reduction/Brook rearrangement/aldol sequence between silyl glyoxylates and aldehydes that achieves catalytic turnover through alkoxide transfer from a strain-release Lewis acidic silacycle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13fc942fd2be60391601fa3576f2b05
https://doi.org/10.1021/ol802828d
https://doi.org/10.1021/ol802828d
Publikováno v:
ChemInform. 43
Depending on the substitution pattern, the reaction of internal alkynes with 4-hydroxy-1,6-enynes can lead to the products of alkene—alkyne coupling, alkyne—alkyne coupling or [2 + 2 + 2] annulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb7422c0550bf5b37ab625a963a4d43c
https://doi.org/10.1002/chin.201233104
https://doi.org/10.1002/chin.201233104
Autor:
Daniel C. Schmitt, Gregory R. Boyce, Xin Linghi, Jeffrey S. Johnson, Justin T. Malinowski, Stephen N. Greszler, Kimberly M. Steward, Andrew Duncan Satterfield, David A. Nicewicz
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0029746fd2f0dffacf76b79ca5e31baa
https://doi.org/10.1002/chin.201229262
https://doi.org/10.1002/chin.201229262
A convergent synthesis of highly substituted and stereodefined dihydroindanes is described from alkoxide-directed Ti-mediated cross-coupling of internal alkynes with substituted 4-hydroxy-1,6-enynes (substrates that derive from 2-directional function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa35e5c81d5a5245786ad36ab6f726e
https://europepmc.org/articles/PMC3275653/
https://europepmc.org/articles/PMC3275653/
Publikováno v:
ChemInform. 42
Reformatsky reagents react sequentially with silyl glyoxylates and β-lactones to give highly functionalized Claisen condensation products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae945a6028898209ec638ef38508b49
https://doi.org/10.1002/chin.201118050
https://doi.org/10.1002/chin.201118050
A formal synthesis of leustroducsin B has been completed. The synthesis relies upon a recently developed Reformatsky/Claisen condensation of silyl glyoxylates and enantioenriched β-lactones that establishes two of the molecule’s three core stereoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eef6116c5bfe331ee1c6e5352515b57