Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stephen Meek"'
Autor:
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Nicholas Shukeir, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that hete
Externí odkaz:
https://doaj.org/article/8624fe27fea0477cbeee8d7082173fcb
Autor:
Stephen Meek, Tom Watson, Lel Eory, Gus McFarlane, Felicity J. Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Shih, Tim Regan, Ryan Taylor, Linda Sutherland, Anton Gossner, Cosmin Chintoan-Uta, Sarah Fletcher, Philippa M. Beard, Musa A. Hassan, Finn Grey, Jayne C. Hope, Mark P. Stevens, Monika Nowak-Imialek, Heiner Niemann, Pablo J. Ross, Christine Tait-Burkard, Sarah M. Brown, Lucas Lefevre, Gerard Thomson, Barry W. McColl, Alistair B. Lawrence, Alan L. Archibald, Falko Steinbach, Helen R. Crooke, Xuefei Gao, Pentao Liu, Tom Burdon
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and
Externí odkaz:
https://doaj.org/article/cf7ad4f4a1df46abb42ac71785840eab
Autor:
Stephen Meek, Jun Wei, Taeho Oh, Tom Watson, Jaime Olavarrieta, Linda Sutherland, Daniel F. Carlson, Angela Salzano, Tamir Chandra, Anagha Joshi, Tom Burdon
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 154-166 (2020)
Summary: Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell pluri
Externí odkaz:
https://doaj.org/article/73abfeba6940457291fa0e02eb90fc60
Autor:
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14225 (2010)
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombina
Externí odkaz:
https://doaj.org/article/8c371ef902a24926b1013cf4c7153a9b
Autor:
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird
Correlative evidence has suggested that DNA methylation promotes the formation of transcriptionally silent heterochromatin. Accordingly, the methyl-CpG binding domain protein MeCP2 is often portrayed as a constituent of heterochromatin. This interpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d69aa2cb100d0541ef4b5596d423395
https://doi.org/10.1101/2023.05.09.539985
https://doi.org/10.1101/2023.05.09.539985
Autor:
Richard A Axton, Michael Jackson, Maria Kydonaki, Tom Burdon, Stephen Meek, A. H. Taylor, Alexander Medvinsky, Antonella Fidanza, Stanislav Rybtsov, Lesley M. Forrester
Publikováno v:
Stem Cell Reports
Jackson, M, Fidanza, A, Taylor, H, Rybtsov, S, Axton, R, Kydonaki, M, Meek, S, Burdon, T, Medvinsky, A & Forrester, L M 2021, ' Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2021.02.003
Jackson, M, Fidanza, A, Taylor, H, Rybtsov, S, Axton, R, Kydonaki, M, Meek, S, Burdon, T, Medvinsky, A & Forrester, L M 2021, ' Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2021.02.003
Summary Apelin receptor (APLNR/AGTRLl1/APJ) marks a transient cell population during the differentiation of hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells, but its function during the production and maintenance of hematop
Autor:
Jaime Olavarrieta, Stephen Meek, Angela Salzano, Tamir Chandra, Jun Wei, Linda Sutherland, Thomas C Watson, Taeho Oh, Anagha Joshi, Tom Burdon, Daniel F. Carlson
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 14, Iss 1, Pp 154-166 (2020)
Meek, S, Wei, J, Oh, T, Olavarrieta, J, Sutherland, L, Carlson, D F, Salzano, A, Chandra, T, Joshi, A & Burdon, T 2020, ' A stem cell reporter for investigating pluripotency and self-renewal in the rat. ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2019.12.001
Stem Cell Reports, Vol 14, Iss 1, Pp 154-166 (2020)
Meek, S, Wei, J, Oh, T, Olavarrieta, J, Sutherland, L, Carlson, D F, Salzano, A, Chandra, T, Joshi, A & Burdon, T 2020, ' A stem cell reporter for investigating pluripotency and self-renewal in the rat. ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2019.12.001
Summary Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell plurip
Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock
Autor:
Pablo J. Ross, Jayne Hope, Monika Nowak-Imialek, Alan Archibald, Gus R. McFarlane, Heiner Niemann, Christine Tait-Burkard, Linda Sutherland, Sarah Brown, Thomas C Watson, Alistair Lawrence, Pentao Liu, Barry W. McColl, Felicity J. Wynne, Stephen McCleary, Musa A. Hassan, Tom Burdon, Emily Charlton, Finn Grey, Chloe Criag, Anton Gossner, Cosmin Chintoan-Uta, Lucas Lefevre, Xuefei Gao, Stephen Meek, Ryan Taylor, Sarah Fletcher, Tim Regan, Falko Steinbach, Helen Crooke, Laura E.M. Dunn, Barbara Shih, Mark P. Stevens, Lel Eory, Gerard Thomson, Pip Beard
Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a major role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9201f265bd6809a46722e23d9370c94
https://doi.org/10.1101/2021.09.10.459580
https://doi.org/10.1101/2021.09.10.459580
Autor:
Tom Burdon, Bert Binas, Jun Wei, Stephen Meek, Roger G. Sturmey, Linda Sutherland, Michael Clinton
Publikováno v:
Meek, S, Sutherland, L, Wei, J, Sturmey, R, Binas, B, Clinton, M & Burdon, T 2020, ' Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat ', Molecular Reproduction and Development . https://doi.org/10.1002/mrd.23413
The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249a9c301d33a15674cc517fbd5e9d19
https://hdl.handle.net/20.500.11820/a912876f-e3db-4409-bf95-1703b0a95626
https://hdl.handle.net/20.500.11820/a912876f-e3db-4409-bf95-1703b0a95626
Autor:
Stephen Meek, Tom Burdon, Joost Gribnau, Sarra Merzouk, Willy M. Baarends, Aristea Magaraki, Esther Sleddens-Linkels, Cristina Gontan, Agnese Loda
Publikováno v:
Magaraki, A, Loda, A, Gontan, C, Merzouk, S, Sleddens-Linkels, E, Meek, S, Baarends, W M, Burdon, T & Gribnau, J 2019, ' A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation ', Scientific Reports . https://doi.org/10.1038/s41598-019-42246-2
Scientific Reports, 9:6068. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, 9:6068. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
X chromosome inactivation (XCI) is a mammalian specific, developmentally regulated process relying on several mechanisms including antisense transcription, non-coding RNA-mediated silencing, and recruitment of chromatin remodeling complexes. In vitro