Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Stephen Mahler"'
Autor:
Michael A. MacDonald, Matthias Nöbel, Verónica S. Martínez, Kym Baker, Evan Shave, Peter P. Gray, Stephen Mahler, Trent Munro, Lars K. Nielsen, Esteban Marcellin
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion b
Externí odkaz:
https://doaj.org/article/652962a831424760825d57ea8ed6a53f
Autor:
Laura Navone, Thomas Vogl, Pawarisa Luangthongkam, Jo-Anne Blinco, Carlos H. Luna-Flores, Xiaojing Chen, Juhani von Hellens, Stephen Mahler, Robert Speight
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Phytases are widely used commercially as dietary supplements for swine and poultry to increase the digestibility of phytic acid. Enzyme development has focused on increasing thermostability to withstand the high temperatures durin
Externí odkaz:
https://doaj.org/article/25bdc4806a084f02bbc6c9b865b5ebb8
Autor:
Michael A. MacDonald, Craig Barry, Teddy Groves, Verónica S. Martínez, Peter P. Gray, Kym Baker, Evan Shave, Stephen Mahler, Trent Munro, Esteban Marcellin, Lars K. Nielsen
Publikováno v:
MacDonald, M A, Barry, C, Groves, T, Martínez, V S, Gray, P P, Baker, K, Shave, E, Mahler, S, Munro, T, Marcellin, E & Nielsen, L K 2022, ' Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok ', Biotechnology and Bioengineering, vol. 119, no. 6, pp. 1380-1391 . https://doi.org/10.1002/bit.28062
Chinese hamster ovary (CHO) cells are the primary platform for the production of biopharmaceuticals. To increase yields, many CHO cell lines have been genetically engineered to resist cell death. However, the kinetics that governs cell fate in biorea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ea2d29dfe0a37da2c4d3cd25ac225b
https://doi.org/10.1002/bit.28062
https://doi.org/10.1002/bit.28062
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 586-594 (2009)
Oxidized HDL has been proposed to play a key role in atherogenesis. A wide range of reactive intermediates oxidizes methionine residues to methionine sulfoxide (MetO) in apolipoprotein A-I (apoA-I), the major HDL protein. These reactive species inclu
Externí odkaz:
https://doaj.org/article/61273387f92948028c8399cdfdea06e7
Publikováno v:
ECS Meeting Abstracts. :708-708
Developing new approaches to monitor critical analytes in complex biological environments is key to the development of new diagnostic tools for application in a range of fields including the biomedical, environmental and food sciences. While reversib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb26de03f0b47be33204c4fb5756d83
https://doi.org/10.1149/ma2022-018708mtgabs
https://doi.org/10.1149/ma2022-018708mtgabs
Publikováno v:
Transfusion Medicine. Nov2022 Supplement 1, Vol. 32, p3-37. 35p. 1 Color Photograph, 1 Diagram, 8 Charts, 5 Graphs.
Autor:
MacDonald, Michael A.1,2 (AUTHOR), Nöbel, Matthias1,2 (AUTHOR), Roche Recinos, Dinora1,3 (AUTHOR), Martínez, Verónica S.1 (AUTHOR), Schulz, Benjamin L.1,4 (AUTHOR), Howard, Christopher B.1 (AUTHOR), Baker, Kym2 (AUTHOR), Shave, Evan2 (AUTHOR), Lee, Yih Yean3 (AUTHOR), Marcellin, Esteban1,5 (AUTHOR), Mahler, Stephen1 (AUTHOR), Nielsen, Lars Keld1,5,6 (AUTHOR), Munro, Trent1,7 (AUTHOR)
Publikováno v:
Critical Reviews in Biotechnology. Nov2022, Vol. 42 Issue 7, p1099-1115. 17p.
Publikováno v:
Psychopharmacology. Jul2022, Vol. 239 Issue 7, p2363-2363. 1p.
Autor:
Navone, Laura1,2 (AUTHOR) laura.navone@qut.edu.au, Vogl, Thomas3 (AUTHOR), Luangthongkam, Pawarisa1 (AUTHOR), Blinco, Jo-Anne1 (AUTHOR), Luna-Flores, Carlos H.1,4 (AUTHOR), Chen, Xiaojing4 (AUTHOR), von Hellens, Juhani4 (AUTHOR), Mahler, Stephen5 (AUTHOR), Speight, Robert1,2 (AUTHOR)
Publikováno v:
Biotechnology for Biofuels. 3/31/2021, Vol. 14 Issue 1, p1-14. 14p.