Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Stephen MacKinnon"'
Autor:
Emma Das-Gupta, Kirsty J. Thomson, Adrian J.C. Bloor, Andrew D. Clark, Stephen Mackinnon, Irfan Kayani, Laura Clifton-Hadley, Pip Patrick, Nadjet El-Mehidi, Anthony Lawrie, Amy A. Kirkwood, Nigel H. Russell, David C. Linch, Karl S. Peggs
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4264-4270 (2019)
Abstract: We evaluated the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in transplant-naïve patients with relapsed/refractory Hodgkin lymphoma (HL) who failed to attain metabolic complete response (mCR) to 1 to 2 lines of s
Externí odkaz:
https://doaj.org/article/fcbef3681889418ebbc0e8a61fd4114f
Autor:
Shawn Reeves, Benjamin DiFrancesco, Vijay Shahani, Stephen MacKinnon, Andreas Windemuth, Andrew E. Brereton
Publikováno v:
Applied AI Letters, Vol 1, Iss 2, Pp n/a-n/a (2020)
Abstract Benchmarking the performance of generative methods for drug design is complex and multifaceted. In this report, we propose a separation of concerns for de novo drug design, categorizing the task into three main categories: generation, discri
Externí odkaz:
https://doaj.org/article/b8def4f5db974a45a3102159f992416e
Autor:
Maria M. Cuadrado, Richard M. Szydlo, Mike Watts, Nishil Patel, Hanna Renshaw, Jude Dorman, Mark Lowdell, Stuart Ings, Chloe Anthias, Alejandro Madrigal, Stephen Mackinnon, Panagiotis Kottaridis, Ben Carpenter, Rachael Hough, Emma Morris, Kirsty Thomson, Karl S. Peggs, Ronjon Chakraverty
Publikováno v:
Haematologica, Vol 105, Iss 11 (2019)
Poor graft function is a serious complication following allogeneic hematopoietic stem cell transplantation. Infusion of CD34+-selected stem cells without pre-conditioning has been used to correct poor graft function, but predictors of recovery are un
Externí odkaz:
https://doaj.org/article/e4c71e8fe9b44e8a8fab72731ed805f0
Autor:
Paul D Griffiths, Emily Rothwell, Mohammed Raza, Stephanie Wilmore, Tomas Doyle, Mark Harber, James O'Beirne, Stephen Mackinnon, Gareth Jones, Douglas Thorburn, Frank Mattes, Gaia Nebbia, Sowsan Atabani, Colette Smith, Anna Stanton, Vincent C Emery
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185298 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0163722.].
Externí odkaz:
https://doaj.org/article/99f9e060d65948cba7bd397c1fb8aa07
Autor:
Esteban Arrieta-Bolaños, Neema P. Mayor, Steven G.E. Marsh, J. Alejandro Madrigal, Jane F. Apperley, Keiren Kirkland, Stephen Mackinnon, David I. Marks, Grant McQuaker, Julia Perry, Michael N. Potter, Nigel H. Russell, Kirsty Thomson, Bronwen E. Shaw
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Transforming growth factor β-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiological and pathogenic processes. We have sequenced TGFB1 regulatory region and assigned allelic genotypes in a large cohort of hematopo
Externí odkaz:
https://doaj.org/article/10211a0729b0476e918d0ed826e11fb2
Autor:
Paul D Griffiths, Emily Rothwell, Mohammed Raza, Stephanie Wilmore, Tomas Doyle, Mark Harber, James O'Beirne, Stephen Mackinnon, Gareth Jones, Douglas Thorburn, Frank Mattes, Gaia Nebbia, Sowsan Atabani, Colette Smith, Anna Stanton, Vincent C Emery
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163722 (2016)
To help decide when to start and when to stop pre-emptive therapy for cytomegalovirus infection, we conducted two open-label randomized controlled trials in renal, liver and bone marrow transplant recipients in a single centre where pre-emptive thera
Externí odkaz:
https://doaj.org/article/a73f4fbee9444bdabe09a02f4054da3d
Autor:
Stephen Mackinnon, Karl Peggs
Publikováno v:
Revista Brasileira de Hematologia e Hemoterapia, Vol 24, Iss 2, Pp 67-75 (2002)
The dose escalation of chemo-radiotherapy that is achievable with stem cell transplantation is often insufficient to eradicate malignancy, and an associated immune-mediated graft-versus-malignancy effect may be equally important for many diseases. Th
Externí odkaz:
https://doaj.org/article/ad984a56e4b14a8696262329ac660d67
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85911 (2014)
Previous studies have demonstrated the effective control of cytomegalovirus (CMV) infections post haematopoietic stem cell transplant through the adoptive transfer of donor derived CMV-specific T cells (CMV-T). Strategies for manufacturing CMV immuno
Externí odkaz:
https://doaj.org/article/ba3f4156a5924174a7074cf753b694ac
Autor:
Silvia Montoto, Paolo Corradini, Martin Dreyling, Michele Ghielmini, Eva Kimby, Armando López-Guillermo, Stephen Mackinnon, Robert E. Marcus, Gilles Salles, Harry C Schouten, Anna Sureda, Peter Dreger
Publikováno v:
Haematologica, Vol 98, Iss 7 (2013)
The aim of this project was to define indications for hematopoietic stem cell transplantation in follicular lymphoma in Europe. In the absence of evidence-based data, a RAND-modified Delphi procedure was used by an expert panel. After pre-defining st
Externí odkaz:
https://doaj.org/article/fd6266558d2d499b8e6a046d1ecf0287
Autor:
Charles Craddock, Sandeep Nagra, Andrew Peniket, Cassandra Brookes, Laura Buckley, Emmanouil Nikolousis, Nick Duncan, Sudhir Tauro, John Yin, Effie Liakopoulou, Panos Kottaridis, John Snowden, Donald Milligan, Gordon Cook, Eleni Tholouli, Tim Littlewood, Karl Peggs, Paresh Vyas, Fiona Clark, Mark Cook, Stephen MacKinnon, Nigel Russell
Publikováno v:
Haematologica, Vol 95, Iss 6 (2010)
Background Reduced intensity conditioning regimens permit the delivery of a potentially curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. Although T-cell depletion is increasingly used to reduce the risk of graft-ve
Externí odkaz:
https://doaj.org/article/9884d138637b4bb3ae5cc45c8ef54b74